中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (33): 6243-6247.doi: 10.3969/j.issn.2095-4344.2012.33.032

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

基质金属蛋白酶与椎间盘的退变

荆鹏伟，刘泽汉，何 旭，公伟勋，王立春   

  1. 哈尔滨医科大学附属第二医院骨科，黑龙江省哈尔滨市 150081
  • 收稿日期:2011-12-07 修回日期:2012-01-31 出版日期:2012-08-12 发布日期:2012-08-12
  • 通讯作者: 王立春，博士，副主任医师，副教授，哈尔滨医科大学附属第二医院骨科，黑龙江省哈尔滨市 150081 wlcbox@sina.com
  • 作者简介:荆鹏伟★，男，1985年生，山东省烟台市人，汉族，哈尔滨医科大学在读硕士，主要从事基质金属蛋白酶参与椎间盘退变的实验研究。 pw7218804@sina.com

Matrix metalloproteinases and disc degeneration

Jing Peng-wei, Liu Ze-han, He Xu, Gong Wei-xun, Wang Li-chun   

  1. Department of Orthopedics, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
  • Received:2011-12-07 Revised:2012-01-31 Online:2012-08-12 Published:2012-08-12
  • Contact: Wang Li-chun, Doctor, Associate chief physician, Associate professor, Department of Orthopedics, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China wlcbox@sina.com
  • About author:Jing Peng-wei★, Studying for master’s degree, Department of Orthopedics, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China jpw7218804@sina.com

PDF

376

被引次数

20

摘要：

背景：椎间盘细胞外基质的破坏是椎间盘退变的主要标志，已经证实这与主要基质金属蛋白酶的表达和活性上调有关。然而到目前为止对于基质金属蛋白酶家族的调节几乎没有系统的资料。
目的：全面了解基质金属蛋白酶在椎间盘退变中的表达及作用。
方法：由第一作者用计算机检索中国生物医学全文数据库(SinoMed：2000/2011)和Medline数据库(2000/2011)，检索词分别为“基质金属蛋白酶，基质金属蛋白酶组织抑制因子，椎间盘，退行性变，脊柱”和“matrix metalloproteinases，tissue inhibitor of matrix metalloproteinases，disc，degeneration，intervertebral”。共检索到207篇文章，按纳入和排除标准对文献进行筛选，共纳入31篇文章。回顾收录的基质金属蛋白酶相关综述和论文报告，并分析生物学作用及调节的研究进展。
结果与结论：基质金属蛋白酶在椎间盘退变中起着重要作用，已有证据表明基质金属蛋白酶能加速椎间盘细胞外基质的退变进程，并已取得了大量免疫组化证据的支持。

关键词: 基质金属蛋白酶, 基质金属蛋白酶组织抑制因子, 椎间盘, 退变, 脊柱

Abstract:

BACKGROUND: The disruption of the extracellular disc matrix is a major hallmark of disc degeneration. This has previously been shown to be associated with an up-regulation of major matrix metalloproteinase expression and activity. However, until now hardly any data are available for matrix metalloproteinase regulation and thereby no concept exists as to which matrix metalloproteinase plays a major role in disc degeneration.
OBJECTIVE: To understand the expression and role of matrix metalloproteinase in intervertebral disc degeneration.
METHODS: matrix metalloproteinase relevant articles from Chinese Biomedical Literature Database and Medline database 2000/2010 were retrieved by the first author using key words “matrix metalloproteinases, tissue inhibitor of matrix metalloproteinases, disc, degeneration, spine, intervertebral” in Chinese and English. A total of 207 papers were retrieved. According to inclusion and exclusion criteria, 31 papers were included in the final. Then, the development of matrix metalloproteinase expression and regulation on intervertebral disc degeneration was studied.
RESULTS AND CONCLUTION: With deeply research, matrix metalloproteinase may play an important role in intervertebral disc degeneration. There are some evidences to indicate that matrix metalloproteinase can accelerate the progression of disc excellular matrix degeneration

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