中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (44): 8279-8282.doi: 10.3969/j.issn.2095-4344.2012.44.021

• 骨与关节综述 bone and joint review • 上一篇    下一篇

建立股骨头坏死动物模型的最新信息

冯金柱，王 瑞，赵建宁   

  1. 南京大学医学院临床学院(解放军南京军区南京总医院骨科)，江苏省南京市 210002
  • 收稿日期:2012-01-05 修回日期:2012-01-29 出版日期:2012-10-28 发布日期:2013-04-07
  • 通讯作者: 赵建宁，教授，主任医师，博士生导师，解放军南京军区南京总医院骨科，江苏省南京市 210002 zhaojianning.0207@163.com
  • 作者简介:冯金柱★，男，1987年生，汉族，江苏省淮安市人，南京大学医学院临床学院(解放军南京军区南京总医院骨科)在读硕士，主要从事关节外科方面的研究。 Huaiyingzhu@163.com

Latest information of the establishment of an animal model of femoral head necrosis

Feng Jin-zhu, Wang Rui, Zhao Jian-ning   

  1. Clinical College, Medical School of Nanjing University (Department of Orthopedics, Nanjing General Hospital of Nanjing Military Region of Chinese PLA), Nanjing 210002, Jiangsu Province, China
  • Received:2012-01-05 Revised:2012-01-29 Online:2012-10-28 Published:2013-04-07
  • Contact: Zhao Jian-ning, Professor, Chief physician, Doctoral supervisor, Clinical College, Medical School of Nanjing University (Department of Orthopedics, Nanjing General Hospital of Nanjing Military Region of Chinese PLA), Nanjing 210002, Jiangsu Province, China zhaojianning.0207@163.com
  • About author:Feng Jin-zhu★, Studying for master’s degree, Clinical College, Medical School of Nanjing University (Department of Orthopedics, Nanjing General Hospital of Nanjing Military Region of Chinese PLA), Nanjing 210002, Jiangsu Province, China Huaiyingzhu@163.com

PDF

422

被引次数

7

摘要：

背景：在临床骨科研究方面，为了研究股骨头坏死的病因及发病机制，从根本上进行治疗，出现了各种各样的股骨头坏死的动物模型。
目的：对近几年来学者们建立的各种各样股骨头坏死的改良模型作一个综述，分析各种模型的优劣，用来指导临床对股骨头坏死发病机制进行研究或者评价一种新的治疗方法的临床价值。
方法：以“股骨头坏死；动物模型”或“femoral head necrosis; animal model”为检索词检索CNKI中国知网数据库和PubMed数据库中2005年1月至2011年12月关于建立股骨头坏死动物模型的相关文献136篇，根据纳入标准选择20篇文章进行分析。
结果与结论：目前采用最多的建模方法是改良激素型，但是不同的造模方法都有其自己的优缺点，动物模型的建立方法的选择，应该与自己实验目的紧紧相连。无论是为了病因及发病机制研究，还是治疗效果的评价，建立动物模型的方法都还需要进一步完善。

关键词: 股骨头坏死, 动物模型, 机制, 病因, 最新进展

Abstract:

BACKGROUND: In clinical orthopedic research, a variety of femoral head necrosis animal models have emerged in order to study the etiology and pathogenesis of femoral head necrosis and give a fundamental treatment.
OBJECTIVE: To give a review to the variety of femoral head necrosis improved model established by scholars in recent years, and to analyze the pros and cons of various models, in order to help to study the osteonecrosis pathogenesis or evaluate the clinical value of a new treatment.
METHODS: The CNKI database and PubMed database (2005-01/2011-12) were used to retrieve the articles on the establishment of femoral head necrosis animal models with the key words of “femoral head necrosis, animal model” in English and Chinese. A total of 136 articles were obtained and finally 16 articles were included to review according to the inclusion criteria.
RESULTS AND CONCLUSION: The improved methods of steroid-induced are most used in modeling approach currently, but different modeling approach has its own advantages and disadvantages. Each method should be closely linked with its experimental purpose. And no matter for the study of the etiology and pathogenesis, or the evaluation of treatment, the methods to establish the animal model still needs further improvement.

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