中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (43): 8089-8092.doi: 10.3969/j.issn.1673-8225.2011.43.027

• 数字化骨科 digital orthopedics • 上一篇    下一篇

呼吸门控对呼吸运动引起组织位移造成靶区精度复位差的作用

张  洁，赵纯亮，谭坚文，钟  玲，王  华   

  1. 重庆医科大学生物医学工程学院省部共建超声医学工程国家重点实验室超声医学工程重庆市市级重点实验室，重庆市  400016
  • 收稿日期:2011-04-12 修回日期:2011-09-07 出版日期:2011-10-22 发布日期:2011-10-22
  • 通讯作者: 王华，教授，重庆医科大学生物医学工程学院省部共建超声医学工程国家重点实验室超声医学工程重庆市市级重点实室，重庆市 400016 wangh@haifu.com.cn
  • 作者简介:张洁★，女，1985年生，贵州省毕节市人，彝族，2011年重庆医科大学毕业，硕士，主要从事超声医学的研究。 zhangj6647@163.com
  • 基金资助:

    国家重点基础研究发展计划(973计划)(2011CB707902)；国家自然科学基金重点项目(30830040)。

Focal target controlling during high intensity focused ultrasound therapy based on respiratory gating

Zhang Jie, Zhao Chun-liang, Tan Jian-wen, Zhong Ling, Wang Hua   

  1. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical University, Chongqing  400016, China
  • Received:2011-04-12 Revised:2011-09-07 Online:2011-10-22 Published:2011-10-22
  • Contact: Wang Hua, Professor, State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China wangh@haifu.com.cn
  • About author:Zhang Jie★, Master, State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China zhangj6647@163.com
  • Supported by:

    the National 973 Program of China, No. 2011CB707902*; the National Natural Science Foundation of China, No. 30830040*

PDF

437

被引次数

11

摘要：

背景：在常规高强度聚焦超声治疗中，如何避免呼吸运动引起的脏器组织位移从而影响辐照靶区定位精度及治疗的安全性是目前急需解决的问题。
目的：探讨在高强度聚焦超声治疗过程中，利用呼吸门控技术提高高强度聚焦超声治疗靶点定位精度的可行性。
方法：在相同声强、辐照时间情况下，利用压阻式微型呼吸传感器，基于呼吸门控技术控制高强度聚焦超声治疗设备对活体兔肝脏组织进行定点辐照，与用常规高强度聚焦超声治疗方法的定点辐照对比，并检测凝固性坏死的情况。
结果与结论：辐照后将动物解剖，取出其肝脏，找到辐照靶区，测得利用呼吸门控技术定点辐照的最大剖面焦区大小为 4.5 mm×2.0 mm，用常规的高强度聚焦超声治疗方法定点辐照的最大剖面焦区大小为9.0 mm×2.5 mm。提示呼吸门控技术能够有效消除呼吸运动引起组织移位造成的靶区定位精度的影响。

关键词: 高强度聚焦超声, 治疗靶点, 呼吸运动, 实时监测, 呼吸门控

Abstract:

BACKGROUND: It is an urgent problem to be solved that the organ of displacement caused by breathing could affect the precision of the target of orientation and also the safety of the therapy during the routine treatment.
OBJECTIVE: To study the feasibility that using the respiratory gating to improve the accuracy of focal point positioning during high intensity focused ultrasound (HIFU) therapy.
METHODS: HIFU ablation based on breathing gated control using piezoresistive micro-breathing sensor was applied to the rabbit liver in vivo, which was compared with the normal HIFU ablation procesure for the difference in coagulative necrosis produced under the same ultrasound intensity and ablation duration.
RESULTS AND CONCLUSION: The rabbits were executed immediately after HIFU ablation to investigate lesions inside the liver. Results showed that the biological focal region using breathing gated HIFU ablation was 4.5 mm×2 mm at the largest sectional plane, while that using normal HIFU ablation procesure was 9 mm×2.5 mm. The respiratory gating could eliminate the influence of the accuracy of focal point positioning during HIFU therapy.

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