中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (30): 5689-5692.doi: 10.3969/j.issn.1673-8225.2011.30.043

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    下一篇

骨折延迟愈合及骨不连与阻塞性睡眠呼吸暂停的相关性

张建国1，王  东1，宋  璐2   

  1. 山西医科大学第二医院，1骨科，2呼吸科，山西省太原市  030001
  • 收稿日期:2011-01-30 修回日期:2011-03-16 出版日期:2011-07-23 发布日期:2011-07-23
  • 通讯作者: 王东，博士，教授，博士生导师，山西医科大学第二医院骨科，山西省太原市 030001
  • 作者简介:张建国★，男，1983年生，山西省太原市人，汉族，山西医科大学在读硕士，主要从事骨折愈合机制研究。 z_j_g886@163.com

Delayed union and nonunion associated with obstructive sleep apnea

Zhang Jian-guo1, Wang Dong1, Song Lu2    

  1. 1Department of Orthopedics, 2Department of Respiration, the Second Hospital of Shanxi Medical University, Taiyuan  030001, Shanxi Province, China
  • Received:2011-01-30 Revised:2011-03-16 Online:2011-07-23 Published:2011-07-23
  • Contact: Wang Dong, Ph.D., Professor, Doctoral supervisor, Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • About author:Zhang Jian-guo★, Studying for master’s degree, Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China z_j_g886@163.com

PDF

519

被引次数

12

摘要：

背景：阻塞性睡眠呼吸暂停能影响成骨和/或破骨细胞及骨愈合相关调节蛋白，使骨折患者不易愈合或加重不愈合的程度。
目的：观察阻塞性睡眠呼吸暂停与骨不连的相关性。
方法：随机选取338例骨折的患者，其中骨愈合患者228例，骨不连110例，经便携式睡眠仪筛查出合并阻塞性睡眠呼吸暂停的骨不连患者11例，分析监测数据与临床资料的相关性。
结果与结论：与骨愈合患者相比，骨不连患者阻塞性睡眠呼吸暂停患病率较高(P < 0.05)，比值比(OR)=2.422，95%CI=0.996~5.891，合并阻塞性睡眠呼吸暂停的骨不连患者愈合时间与最低血氧饱和度、平均血氧饱和度呈负相关(r分别为0.40和0.38，P < 0.05)，骨痂X射线评分与最低血氧饱和度、平均血氧饱和度呈正相关(r分别为0.34和0.47，P < 0.05)。提示阻塞性睡眠呼吸暂停可能是骨不连新的危险因素之一。

关键词: 骨不连, 阻塞性睡眠呼吸暂停, 延迟愈合, 血氧饱和度, 相关性

Abstract:

BACKGROUND: Obstructive sleep apnea (OSA) can affect the expression of regulatory proteins associated with bone and/or osteoclasts and bone healing, so the factures are difficult to heal and even aggravated.
OBJECTIVE: To observe the association of OSA and nonunion.
METHODS: Randomly selected in our hospital from June 2005 to June 2010 were 338 cases of fractures, of which 228 were patients with bone healing and 110 were patients with nonunion (11 cases combined with OSA confirmed by a portable sleep screening instrument). Monitoring data and relevant clinical data were analyzed.
RESULTS AND CONCLUSION: Compared to patients with bone healing, OSA prevalence was higher in nonunion patients (P < 0.05), odds ratio(OR)=2.422, 95% confidence index (CI)=0.996-5.891; in the nonunion with OSA group, the healing time was correlated negatively with minimum oxygen saturation during the night (LSaO2) and average oxygen saturation (MSaO2) (r=0.40, 0.38, P < 0.05), and the X-callus score was correlated positively with LSaO2 and MSaO2 (r=0.34, 0.47, P < 0.05).OSA may be the new risk factors of nonunion.

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