中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (24): 4522-4524.doi: 10.3969/j.issn.1673-8225.2011.24.038

• 骨组织构建 bone tissue construction • 上一篇    下一篇

诱骗受体1在椎间盘组织中的表达

杨吉坤，张国庆，陈伯华   

  1. 青岛大学医学院附属医院脊柱外科，山东省青岛市  266003
  • 收稿日期:2011-03-01 修回日期:2011-04-10 出版日期:2011-06-11 发布日期:2011-06-11
  • 通讯作者: 张国庆，硕士，教授，主任医师。青岛大学医学院附属医院脊柱外科，山东省青岛市 266003
  • 作者简介:杨吉坤★，男，1983年生，山东省青岛市人，汉族，青岛大学在读硕士，主要从事脊柱外科方面的研究。

Decoy receptor 1 expression in the intervertebral discs

Yang Ji-kun, Zhang Guo-qing, Chen Bo-hua   

  1. Department of Spine Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao  266003, Shandong Province, China
  • Received:2011-03-01 Revised:2011-04-10 Online:2011-06-11 Published:2011-06-11
  • Contact: Zhang Guo-qing, Master, Professor, Chief physician, Department of Spine Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
  • About author:Yang Ji-kun★, Studying for master’s degree, Department of Spine Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China yangjikun@126.com

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273

被引次数

1

摘要：

背景：诱骗受体1输肿瘤坏死因子相关凋亡配体受体，其可能作为诱饵受体生理性阻断细胞凋亡过程。
目的：观察诱骗受体1在突出和正常腰椎间盘组织中的表达。
方法：2010-01/09收集退行性椎间盘患者手术切除的突出椎间盘标本20个及自愿流产的胎儿的正常腰椎间盘标本8个，免疫组化方法检测诱骗受体1蛋白在不同椎间盘组织中的分布。
结果与结论：突出腰椎间盘组织中诱骗受体1阳性表达的髓核和纤维环细胞明显多于正常椎间盘，说明突出椎间盘组织中诱骗受体的表达提高。

关键词: 诱骗受体1, 腰椎, 椎间盘, 肿瘤坏死因子相关凋亡诱导配体, 软组织构建

Abstract:

BACKGROUND: Decoy receptor 1 (DcR1), which acts as decoy receptors, is resistant to apoptosis induction by related apoptosis inducing ligand (TRAIL).
OBJECTIVE: To investigate the expression of the DcR1 (TRAIL-R3) protein in human herniated and normal lumbar intervertebral discs (IVD).
METHODS: The expression and distribution of DcR1 proteins were assessed by using immunohistochemistry in 20 herniated lumbar IVD and 8 normal lumbar IVD tissues samples following discoidectomy from January to September 2010.
RESULTS AND CONCLUSION: Percentage of nucleus pulposus and anulus fibrous cells with DCR1 expression was obviously more in the herniated group than in normal IVD group. The current results indicate that the expression of DCR1 rises after herniation.

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