中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (23): 4257-4261.doi: 10.3969/j.issn.1673-8225.2011.23.018

• 干细胞移植 stem cell transplantation • 上一篇    下一篇

异基因造血干细胞移植后EB病毒再激活的危险因素分析

曹星辉，范志平，江千里，赵  捷，余国攀，韦  祁，孙  竞，刘启发   

  1. 南方医科大学南方医院血液科，广东省广州市510515
  • 收稿日期:2011-04-08 修回日期:2011-05-10 出版日期:2011-06-04 发布日期:2011-06-04
  • 通讯作者: 范志平，硕士，讲师，主治医师，南方医科大学南方医院血液科，广东省广州市 510515 fanzp@fimmun.com 并列通讯作者：刘启发，硕士，教授，主任医师，博士生导师，南方医科大学南方医院血液科，广东省广州市 510515 liuqifa@fimmu.com
  • 作者简介:曹星辉★，女，1981年生，湖南省娄底市人，汉族，2010南方医科大学毕业，硕士，医师，主要从事造血干细胞移植免疫的研究 caoxinghui24wu@163.com
  • 基金资助:

    国家 863 计划－卫生行业科研专项项目(201002024)；国家自然科学基金(30971300)。

Risk factors for Epstein-barr virus reactivation after allogeneic hematopoietic stem cells transplantation

Cao Xing-hui, Fan Zhi-ping, Jiang Qian-li, Zhao Jie, Yu Guo-pan, Wei Qi, Sun Jing, Liu Qi-fa   

  1. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2011-04-08 Revised:2011-05-10 Online:2011-06-04 Published:2011-06-04
  • Contact: Fan Zhi-ping, Master, Lecturer, Attending physician, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China fanzp@fimmun.com Correspondence to: Liu Qi-fa, Master, Professor, Chief physician, Doctoral supervisor, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China liuqifa@fimmu.com
  • About author:Cao Xing-hui★, Master, Physician, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China caoxinghui24wu@163.com
  • Supported by:

    the National High-Tech Research and Development Plan of China, No. 2006AA02Z4A0*; the National Natural Science Foundation of China, No. 30971300*

PDF

358

被引次数

11

摘要：

背景：异基因造血干细胞移植后EB病毒再激活可导致致死性的移植后淋巴细胞增殖性疾病及相关疾病，目前国内尚未建立完整的EB病毒再激活及其相关性疾病的诊疗体系。
目的：前瞻性研究异基因造血干细胞移植后患者EB病毒再激活的发生和相关危险因素。
方法：纳入129例接受异基因造血干细胞移植的患者，采用实时定量PCR方法定期测定外周血中EB病毒载量，Kaplan-Meier模型分析其再激活的发生率，Logistic回归分析模型分析其再激活的相关危险因素。
结果与结论：异基因造血干细胞移植后EB病毒再激活及其相关疾病发生率高，EB病毒再激活发生的危险因素有HLA配型不合、应用抗胸腺细胞球蛋白、Ⅲ~Ⅳ度急性移植物抗宿主病及年龄小于20岁。

关键词: EB病毒再激活, 异基因造血干细胞移植, 危险因素, 抗胸腺细胞球蛋白, 移植物抗宿主病

Abstract:

BACKGROUND: Epstein-barr virus (EBV) reactivation following allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cause deadly post-transplant lymphoproliferative disorders and other EBV-associated diseases. At present, a complete diagnosis and treatment system about EBV reactivation and EBV-related disease has not been established in China.
OBJECTIVE: To investigate prospectively the incidence of EBV reactivation and risk factors following allo-HSCT.
METHODS: 129 patients receiving allo-HSCT were included. EBV-DNA in peripheral blood were detected by real-time PCR; Kaplan-Meier model was used for analyzing cumulative incidence of EBV reactivation, and binary logistic regression model was used for analyzing risk factors of EBV reactivation.
RESULTS AND CONCLUSION: EBV reactivation and EBV associated disease have high incidence rate after allo-HSCT. Risk factors for EBV reactivation include HLA mismatched, use of antithymocyte globulin, grade III-IV acute graft-versus-host disease and age less than or equal to 20 years old.

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