中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (19): 3598-3601.doi: 10.3969/j.issn.1673-8225.2011.19.043

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

不完全性颈髓损伤高位截瘫1例患者的循证治疗

潘  萍，杨  棋，梁清乐   

  1. 湖北省人胚胎干细胞研究重点实验室，湖北医药学院附属太和医院，湖北省十堰市 442000
  • 收稿日期:2010-11-18 修回日期:2011-02-09 出版日期:2011-05-07 发布日期:2011-05-07
  • 通讯作者: 梁清乐，硕士，助理研究员，湖北省人胚胎干细胞研究重点实验室，湖北医药学院附属太和医院，湖北省十堰市 442000 liangqingle@gmail.com
  • 作者简介:潘萍，女，1963年生，湖北省丹江口市人，汉族，2005年湖北省省委党校毕业，会计师，主要从事医院经济管理和循证医学工作。 wdmqwuz727@sohu.com

Evidence-based treatment for incomplete spinal cord injury induced paraplegia in 1 case 

Pan Ping, Yang Qi, Liang Qing-le   

  1. Key Laboratory of Human Embryonic Stem Cell Research in Hubei Province, Taihe Hospital of Hubei Medical College, Shiyan  442000, Hubei Province, China
  • Received:2010-11-18 Revised:2011-02-09 Online:2011-05-07 Published:2011-05-07
  • Contact: Liang Qing-le, Master, Assistant investigator, Key Laboratory of Human Embryonic Stem Cell Research in Hubei Province, Taihe Hospital of Hubei Medical College, Shiyan 442000, Hubei Province, China liangqingle@gmail.com
  • About author:Pan Ping, Accountant, Key Laboratory of Human Embryonic Stem Cell Research in Hubei Province, Taihe Hospital of Hubei Medical College, Shiyan 442000, Hubei Province, China wdmqwuz727@sohu.com

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432

被引次数

1

摘要：

背景：目前脊髓损伤治疗仍是世界难题之一，脊髓损伤后坏死神经元几乎不能再生，不同医院治疗方案均有不同，但均无有效的循证医学支持。
目的：借助循证医学的方法为1例诊断为脊髓损伤的患者制定最为有效的治疗目标及治疗方案。
方法：充分了解该患者病情一般情况后，从Cochran library、Pubmed、Embase上进行搜索。搜索主题词: spinal cord injuries； pharmacotherapy；long-term；rehabilitation；prognosis-assessment；cell transplantation therapy；Prevention- of-complications；meta-analysis；human；RCT；systematic review等。共检出27篇相关文献进入结果分析。
结果与结论：通过检索结果分析，脊髓损伤恢复期患者，最主要的治疗目的为并发症的预防和康复治疗，以尽可能的促进脊髓的再生和功能的恢复。半年后随访，患者病情稳定，可自行排便，上肢肌力有所恢复，下肢痉挛减轻，可自行站立。采用循证治疗的方法，为脊髓损伤患者制定合理的治疗目标和治疗方案，有良好临床效果。

关键词: 脊髓损伤, 循证治疗, 个案报道, 临床效果

Abstract:

BACKGROUND: It is difficult to cure spinal cord injuries (SCI) in the world. The injured neuron can not renew in SCI. The treatment is different in every hospital, but there is not effective evidence based medicine (EBM) to support it.
OBJECTIVE: To choice the best effective treatment target and method depending on the method of EBM for one SCI patient.
METHODS: We searched the Cochran library, Pubmed, and Embase databases after fully acquiring the ordinary circumstances about the patient. The key words were “spinal cord injuries; pharmacotherapy; long-term; rehabilitation; prognosis-assessment; cell transplantation therapy; Prevention-of-complications; Meta-analysis; human; RCT; systematic review”. Twenty-seven articles were included in the result analysis.
RESULTS AND CONCLUSION: The most important aim was to complications prevention and rehabilitation treatment, especially to promote the regeneration and function rehabilitation of the spinal cord as possible as we could. After half a year, the patient’s situation was stable and self-defecation, muscle strength of the upper limb was restored and lower limb spasticity relieved. The patient could self-stand. It is proved that EBM is proper to the situation of the patient. The method of EBM can make good results in clinic when it is selected as the treatment to SCI patients.

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