中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (19): 3577-3580.doi: 10.3969/j.issn.1673-8225.2011.19.038

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

间充质干细胞生物学特性研究现状

林志祥1，徐  皓2   

  1. 1安徽医科大学，安徽省合肥市    230032
    2解放军南京军区福州总医院骨一科，福建省福州市350025
  • 收稿日期:2011-02-26 修回日期:2011-04-06 出版日期:2011-05-07 发布日期:2011-05-07
  • 通讯作者: 徐皓，教授，硕士生导师，解放军南京军区福州总医院骨一科，福建省福州市 350025
  • 作者简介:林志祥★，男，安徽省无为县人，汉族，安徽医科大学在读硕士，主要从事脊柱脊髓损伤研究。 linzhx@yahoo.cn

Current understanding into the biological characteristics of mesenchymal stem cells

Lin Zhi-xiang1, Xu Hao2   

  1. 1Anhui Medical University, Hefei  230032, Anhui Province, China
    2First Department of Orthopedics, Fuzhou General Hospital of Nanjing Military Area Command, Fuzhou  350025, Fujian Province, China
  • Received:2011-02-26 Revised:2011-04-06 Online:2011-05-07 Published:2011-05-07
  • Contact: Xu Hao, Professor, Master’s supervisor, First Department of Orthopedics, Fuzhou General Hospital of Nanjing Military Area Command, Fuzhou 350025, Fujian Province, China
  • About author:Lin Zhi-xiang★, Studying for master’s degree, Anhui Medical University, Hefei 230032, Anhui Province, China linzhx@yahoo.cn

PDF

445

被引次数

11

摘要：

背景：间充质干细胞在组织修复方面的作用已有大量报道，最近还发现其具有免疫调节功能，但对于其发挥作用的具体途径仍不够清楚。
目的：讨论间充质干细胞发挥免疫调节作用的机制。
方法：由第一作者应用计算机检索PubMed数据库2000/2010有关间充质干细胞在组织损伤后的归巢特性及发挥免疫调节功能机制的文献。检索词为“mesenchymal stem cells，tissue repairing，homing，immunomodulatory”，限定文章语言种类为English，检索文献包括研究原著及综述，排除重复性研究。
结果与结论：共保留50篇文献归纳总结。间充质干细胞参与组织损伤修复的作用已被证实，最近发现其还具有免疫调节功能，作用的相关机制多效而复杂，多种因子介导的腺体-受体反应及相关免疫细胞参与此过程。间充质干细胞免疫调节作用的相关机制仍不完全明确，需要进一步的研究来证实及完善。

关键词: 间充质干细胞, 归巢, 趋化因子, 免疫调节, T淋巴细胞

Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs) have been widely used in clinical studies and treatment. Numerous studies have reported beneficial effects of MSCs in tissue repairing as well as immunomodulatory function reported recently. But it is unclear that how MSCs exert the effects.
OBJECTIVE: To discuss the immunomodulatory mechanism of MSCs.
METHODS: The PubMed database was researched using the computer for articles published from 2000 to 2010 using key words “mesenchymal stem cells, tissue repairing, homing, immunomodulatory” in English. Inclusion criteria: articles relevant to the machnism of MSCs to exert homing and immunomodulatory effects after tissue injury. Exclusion criteria: repetitive studies or irrelevant articles.
RESULTS AND CONCLUSION: Totally 50 articles were included in the result analysis. MSCs effects on the repair of tissue injury have been confirmed, and the immune function of MSCs has been reported recently. The mechanism is pleiotropic and redundant, mediated by multiple factors glands - receptor reaction and related immune cells which are involved in this process. The mechanisms of MSCs are still unclear, further researches are needed to confirm and improve, so as to further promote clinical research and treatment.

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