中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (16): 2965-2968.doi: 10.3969/j.issn.1673-8225.2011.16.027

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

食管支架材料选择及在老年食管癌的应用

陈  静1，林  源1，潘兴国2，黄之杰3，张  毅1，张  汝1   

  1. 解放军成都军区总医院，1干部病房，2放疗科，3放射科，四川省成都市  610083
  • 收稿日期:2011-01-09 修回日期:2011-03-08 出版日期:2011-04-16 发布日期:2011-04-16
  • 通讯作者: 张汝，博士，副主任医师，解放军成都军区总医院干部病房，四川省成都市 610083 Zhangru237@163.com
  • 作者简介:陈静，女，1964年生，四川省宜宾地区人，汉族，1988年泸州医学院毕业，副主任医师，主要从事老年消化道疾病、老年消化道肿瘤方面的研究。 cjing408@126.com

Choice and application of esophageal stent materials in senile esophageal carcinoma

Chen Jing1, Lin Yuan1, Pan Xing-guo2, Huang Zhi-jie3, Zhang Yi1, Zhang Ru1   

  1. 1Cadres Ward, 2Department of Radiotherapy, 3Department of Radiology, General Hospital of Chengdu Military Area Command of Chinese PLA, Chengdu  610083, Sichuan Province, China
  • Received:2011-01-09 Revised:2011-03-08 Online:2011-04-16 Published:2011-04-16
  • Contact: Zhang Ru, Doctor, Associate chief physician, Cadres Ward, General Hospital of Chengdu Military Area Command of Chinese PLA, Chengdu 610083, Sichuan Province, China Zhangru237@163.com
  • About author:Chen Jing, Associate chief physician, Cadres Ward, General Hospital of Chengdu Military Area Command of Chinese PLA, Chengdu 610083, Sichuan Province, China Cjing408@126.com

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被引次数

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摘要：

目的：分析组织工程人工食管不同代替材料的应用及相容性，探讨其在老年食管癌置入后的疗效，寻求永久性的人工植入材料。
方法：以gene chip, protein chip, artificial neural network, gastrointestinal cancer, diagnosis”为英文检索词，“组织工程食管、人工食管，生物相容性，食管瘤，诊断”为中文检索词。由第一作者检索2000-01/2010-09PubMed数据及万方数据库，纳入与组织工程食管研究、人工食管置入后的生物相容性评价以及不同材料组织工程食管的实验分析相关的文献，排除重复性研究。保留中英文30篇文献进一步归纳总结。
结果：目前人工食管主要的并发症有吻合口瘘、狭窄、坏死、反流等。未来人工食管的研究方向主要集中在人工食管的构建理念以及构建材料的选择上，主要有以下几种观点：①选择理想的材料并构建成合适的形状。②体外培养-移植体内-诱导食管再生。③研制一种可精确调控的可生物降解的生物型人工食管，直接将其植人机体内，并以此为支撑物，在体内最终诱导、再生出新生的食管。
结论：组织工程食管的研究有朝着应用组织工程学方法构建与正常食管结构相类似的食管替代物，材料的选择从单一的生物惰性材料向可降解吸收的生物活性材料转变的多元化研究发展的趋势。

关键词: 组织工程食管, 人工食管, 材料, 生物相容性, 食管癌

Abstract:

OBJECTIVE: To analyze the application and compatibility of different fungible material of artificial esophagus for tissue engineering, and explore the curative effect on esophageal carcinoma of old patients after implantation, in order to find nonvolatile artificial implant material.
METHODS: Taking “gene chip, protein chip, artificial neural network, gastrointestinal cancer, diagnosis” in English and “tissue engineering esophagus, artificial esophagus, biocompatibility, esophageal carcinoma, diagnosis” in Chinese was utilized as search terms to retrieve PubMed database (2000-01/2010-09) and Wanfang database by the first author. Literatures related to tissue engineering esophageal research, evaluation of biocompatibility after artificial esophagus implantation and experimental analysis of different materials for tissue engineering esophagus were included. Duplicated articles were excluded. A total of 30 literatures were obtained for further summarization.
RESULTS: At present, the main complications of artificial esophagus including anastomotic fistula, narrow, necrosis, contraflow. Future research directions of artificial esophagus are mainly on construction and the choice of material. The main views were as followed: ①Ideal materials were selected and their suitable shape was constructed. ②The materials were cultured in vitro, and transplanted in vivo, then esophageal regeneration was induced. ③A biodegradable biological artificial esophagus with accurate control was developed, and then transplanted into organism and served as supporter, finally induced in vivo so as to regenerate newborn esophagus.
CONCLUSION: The research of tissue engineering esophagus toward the similar esophageal substitute with normal esophageal structure constructed by tissue engineering method, the choice of materials from a single biological inert materials to resorbable and degradable bioactive materials into a diversified research and development trends.

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