中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (48): 9033-9036.doi: 10.3969/j.issn.1673-8225.2010.48.025

• 数字化骨科 digital orthopedics • 上一篇    下一篇

基于微处理器和现场可编程门阵列生物芯片数据采集系统的设计　

郑  斌，万遂人，何农跃　　   

  1. 东南大学生物科学与医学工程学院，医学电子学实验室，江苏省南京市     210096　　　
  • 出版日期:2010-11-26 发布日期:2010-11-26
  • 作者简介:郑斌★，男，1985年生，浙江省长兴县人，汉族，东南大学在读硕士，主要从事嵌入式设计、医学电子研究。 zbing08@126.com
  • 基金资助:

    国家自然科学基金(60927001)。

Design of data acquisition system for biochip based on advanced RISC machines and field programmable gate array

Zheng Bin, Wan Sui-ren, He Nong-yue   

  1. Laboratory of Medical Electronics, College of Bioscience and Medical Engineering, Southeast University, Nanjing  210096, Jiangsu Province, China　
  • Online:2010-11-26 Published:2010-11-26
  • About author:Zheng Bin★, Studying for master’s degree, Laboratory of Medical Electronics, College of Bioscience and Medical Engineering, Southeast University, Nanjing 210096, Jiangsu Province, China zbing08@126.com
  • Supported by:

     the National Natural Science Foundation of China, No. 60927001*

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摘要：

背景：传统将成像装置与计算机相结合的方式制约了生物芯片技术适用的范围。随着生物技术的不断发展，仪器的小型化、集成化、智能化是生物芯片发展的趋势。
目的：实现高速高分辨的实时生物芯片检测系统。
方法：提出一种基于微处理器与现场可编程门阵列协同工作的生物芯片数据采集系统的设计方法，以满足生物芯片在进行高速高分辨率检测时对系统实时性的较高要求。介绍系统的硬件结构和接口设计，并着重讨论了软件的设计与实现，在生物芯片数据采集系统的设计与实现上提出了新的构建方法。 
结果与结论：将微处理器和现场可编程门阵列相结合设计，通过接口驱动和现场可编程门阵列数据采集程序的编写，经QuartusII下的时序仿真，该数据采集系统能够在较高分辨率和较快扫描速度下，实时地进行荧光数据采集。且这种设计方式有效解决了以往采集系统中存在的软硬件过于庞大和复杂的问题，提高了系统可靠性。

关键词: 生物芯片, 微处理器, 现场可编程门阵列, 数据采集

Abstract:

BACKGROUND: Imaging instrument in combination with computer limits application range of biochip. With continuous development of biotechnology, biochip detection requires miniaturization, integrating and intelligentification.
OBJECTIVE: To implement the high speed, high resolution and real-time in biochip detection system.
METHODS: To meet the demands of high speed, high resolution and real time for biochip, a new design of data acquisition based on advanced RISC machines (ARM) and field programmable gate array (FPGA) was introduced. The system hardware architecture and interface design were discussed, with the emphasis on design and implement of software system. It is a new system for design and implementation of biochip detection system.
RESULTS AND CONCLUSION: The system design based on ARM and FPGA can meet the demand of high resolution, high speed and real-time effectively which proved by the simulation. Besides, the design has improved system reliability, and it solves the problems of complex and redundancy of hardware and software design in data acquisition effectively.

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