中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (41): 7739-7742.doi: 10.3969/j.issn.1673-8225.2010.41.034

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

铁调素的表达与调节机制

刘树欣1，卢红梅2，刘玉倩1，王海涛1，康红哲1，李文惠1，陈  军1   

  1. 1河北师范大学体育学院，河北省石家庄市 050016；2安阳师范学院体育学院，河南省安阳市 055000
  • 出版日期:2010-10-08 发布日期:2010-10-08
  • 通讯作者: 刘玉倩，博士，副教授，硕士生导师，河北师范大学体育学院运动人体科学组，河北省石家庄市 050016 yuqianht@126.com
  • 作者简介:刘树欣★，男，1985年生，山东省临沂市人，河北师范大学在读硕士，汉族，主要从事运动与铁代谢研究。 liushuxin19850725@163.com
  • 基金资助:

    文章受国家自然科学基金(30700390)和河北省自然基金(C2009000291)资助。

Expression and regulatory mechanism of hepcidin

Liu Shu-xin1, Lu Hong-mei2, Liu Yu-qian1, Wang Hai-tao1, Kang Hong-zhe1, Li Wen-hui1, Chen Jun1   

  1. 1 College of Physical Education, Hebei Normal University, Shijiazhuang  050016, Hebei Province, China; 2 College of Physical Education, Anyang Normal University, Anyang  055000, Henan Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Liu Yu-qian, Doctor, Associate professor, Master’s supervisor, College of Physical Education, Hebei Normal University, Shijiazhuang 050016, Hebei Province, China yuqianht@126.com
  • About author:Liu Shu-xin★, Studying for master’s degree, College of Physical Education, Hebei Normal University, Shijiazhuang 050016, Hebei Province, China liushuxin19850725@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30700390*; the Natural Science Foundation of Hebei Province, No. C2009000291*

PDF

518

被引次数

19

摘要：

背景：细胞铁的外向转运是由铁调素调节的。铁调素的表达受机体信号因子的影响，如血清铁水平、促红细胞生成素、炎症、低氧、氧化应激等。这些刺激通过肝实质细胞表面的组织相容性Ⅰ型跨膜糖蛋白HFE，转铁蛋白受体1，2，铁调素调节蛋白激活各种信号通路，包括BMP-SMAD、JAK-STAT 和HIF1通路，进而改变铁调素基因的转录，调节铁调素的表达水平，但调节铁调素表达的分子机制还不明确。
目的：从影响铁调素表达的信号因子及信号通路两方面入手，总结并分析铁调素表达的调节机制。
方法：由第一作者通过计算机检索NCBI和SpringerLink（2000/2010）英文数据库，检索词为“Hepcidin，Hemochromatosis，Hemojuvelin，BMP signaling pathway，HFE，TfR1，TfR2”。分别从影响铁调素表达的信号因子及参与其表达调控的信号通路两方面进行总结，介绍近年来在铁调素表达调控机制方面的最新研究进展。
结果与结论：共检索到210篇文章，按纳入和排除标准对文献进行筛选，共纳入37篇文章。结果表明铁调素的表达受机体信号因子的影响，如肝实质细胞表面的遗传性血色素沉着症侯选基因、转铁蛋白受体1，2等，可通过激活各种信号通路，包括BMP-SMAD，JAK-STAT 和HIF1通路，进而改变铁调素基因的转录，并调节其表达。

关键词: 铁调素, 血色素沉着症, 铁调素调节蛋白, 弗林蛋白酶, BMP/SMAD信号通路

Abstract:

BACKGROUND: The cellular iron efflux is modulated by hepcidin derived by liver and this peptide is now regarded as the central regulator of body iron homeostasis. Hepcidin expression is influenced by regulators such as iron store, the rate of erythropoiesis, inflammation, hypoxia and oxidative stress. These regulators control the content of hepcidin by proteins on hepatocyte, such as HFE, transferrin receptor 2, hemojuvelin and the IL-6R and so on. These proteins activate various cell signal transduction pathways, including the BMP-SMAD, JAK-STAT and HIF1 pathways. As a result, the expression of hepcidin is altered. However, the detail molecular mechanism of hepcidin expression remains unclear.
OBJECTIVE: To summarize the regulatory mechanism of hepcidin from the aspects of signal factor and signal pathway.
METHODS: Literatures in NCBI and SpringerLink databases from 2000 to 2010 were searched by the first author using key words of “hepcidin, hemochromatosis, hemojuvelin, BMP signaling pathway, HFE, transferrin receptor 1, transferrin receptor 2”. The latest research regarding regulatory mechanism of hepcidin was analyzed from the aspects of signal factor and signal pathway.
RESULTS AND CONCLUSION: Totally 210 papers were searched by computer, and 37 documents were included according to inclusive and exclusive criteria. The results showed that hepcidin expression was influenced by signal factors such as hereditary hemochromatosis, transferrin receptor 1, and transferrin receptor 2. These proteins activate various cell signal transduction pathways, including the BMP-SMAD, JAK-STAT and HIF1 pathways. As a result, the expression of hepcidin was altered.

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