中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5475-5478.doi: 10.3969/j.issn.1673-8225.2010.29.039

• 生物材料综述 biomaterial review • 上一篇    下一篇

可降解支架材料热学、机械性能及与受体的生物相容性

陈宝爱，罗七一   

  1. 上海理工大学医疗器械与食品学院，上海市  200093
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 作者简介:陈宝爱★，女，1987年生，福建省三明市人，汉族，上海理工大学在读硕士，主要从事生物可降解高分子材料方面的研究。 baoai_chen@163.com

Thermal and mechanical properties of biodegradable stent materials and their biocompatibility with the host

Chen Bao-ai, Luo Qi-yi   

  1. Medical Device and Food College, University of Shanghai for Science and Technology, Shanghai  200093, China
  • Online:2010-07-16 Published:2010-07-16
  • About author: Chen Bao-ai★, Studying for master’s degree, Medical Device and Food College, University of Shanghai for Science and Technology, Shanghai 200093, China baoai_chen@163.com

PDF

739

被引次数

15

摘要：

背景：目前临床上大量使用的金属支架作为异物永久存留于人体会削弱冠状动脉的MRI或是CT影像，此外，金属支架还会干扰外科血运重建，阻碍侧支循环的形成，抑制血管正性重塑，需要给予长期抗血小板治疗。因此，寻找新型生物可降解材料制备临时性、可降解的血管支架成为了研究热点。
目的：详细介绍了可用于制备生物可降解支架的各材料的热学性能、机械性能、降解性能和生物相容性，并结合可降解支架对材料性能的要求，对材料进行初步筛选，并综述了目前可降解支架的研发进展，以期对可降解支架研发工作者的选材工作提供一定的指导作用。
方法：以“biodegradable stent；biodegradable material；PLA；PGA；PCL；PLGA”为检索词，检索Science Direct期刊数据库(2000/2010)。以“生物可降解支架；生物可降解材料；聚乳酸；聚乙交酯；聚己内酯；聚丙交酯/聚乙交酯共聚物”为检索词，检索万方数据库(2002/2010)。文献检索语种限制为英文和中文。要求每篇纳入的文献，属于生物可降解聚合物材料的性能研究和在可降解冠状动脉支架方面的应用研究，并且具备较强的针对性。
结果与结论：经过初步选择筛选出的作为生物可降解冠状动脉支架材料的原材料为聚乳酸，聚乙醇酸，聚己内酯，研究表明，通过它们二者或三者的共混或共聚可以得到合适的热学，机械特性和降解速度，并且在文献报道和临床应用中已有大量研究。可降解支架与永久性金属支架相比所表现出不可替代的优越性，决定了其广阔的应用前景。

关键词: 可降解聚合物, 心血管支架, 材料, 性能, 综述文献

Abstract:

BACKGROUND: Nowadays the metal stent, which is clinically widely used, may weaken the MRI or CT image of the coronary artery as a foreigner in the body. Besides, the metal stent may disturb revascularization, block collateral circulation forming and inhibit vascular remodeling. As a result, it needs antiplatelet therapy for a long time. So, a new biodegradable material to prepare a temporary, degradable coronary stent becomes a hot research.
OBJECTIVE: To introduces in details the thermal properties, mechanical properties, degradation properties and biocompatibility of polymers used in biodegradable stent research. Based on the biodegradable stent’s requirements for the materials, different candidate materials were compared and an elementary selection for proper materials was made. Then the research progress on biodegradable stent materials was reviewed. This paper would work as a guide in the selection of proper material for the biodegradable stent.
METHODS: Using “biodegradable stent, biodegradable material, PLA, PGA, PCL, PLGA” as the key words, Science Direct journal database from 2000 to 2010 was retrieved. Using “biodegradable stent, biodegradable material, PLA, PGA, PCL, PLGA” in Chinese as the key words, Wanfang database from 2002 to 2010 was retrieved. Literatures were limited to English and Chinese. The document retrieval is focused on the properties study of the biodegradable polymer materials and application on biodegradable coronary stent. Every included document is required to have strong point to the criteria.
RESULTS AND CONCLUSION: The initially chosen raw materials for biodegradable coronary stent are PLA, PGA, PCL. Study shows that by blending or co-polymerization of those two or three, appropriate thermal, mechanical properties and degradation speed could be obtained, and numerous studies have conducted in documents and clinical application. Compared to the permanent metal stent, the degradable stent exhibits irreplaceable advantages, which determines its wide application prospect.

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