中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (27): 5095-5098.doi: 10.3969/j.issn.1673-8225.2010.27.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脂肪干细胞的免疫学性质

韩长杰，杨向群，张传森   

  1. 解放军第二军医大学人体解剖学教研室，上海市  200433
  • 出版日期:2010-07-02 发布日期:2010-07-02
  • 通讯作者: 张传森，博士，教授，解放军第二军医大学人体解剖学教研室，上海市 200433
  • 作者简介:韩长杰★，女，1983年生，吉林省长春市人，汉族，解放军第二军医大学在读硕士，主要从事心血管组织工程方面的研究。 hanchangjieyourfirend@yahoo. com.cn
  • 基金资助:

    国家自然科学基金“组织工程窦房结的构建及基础研究”(30970737)；上海市自然科学重点基金“MAPC/EPC性组织工程化静脉瓣的基础与应用”(08441900600)。

Immunological characteristics of adipose-derived stem cells

Han Chang-jie, Yang Xiang-qun, Zhang Chuan-sen   

  1. Department of Human Anatomy, Second Military Medical University of Chinese PLA, Shanghai  200433, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Zhang Chuan-sen, Doctor, Professor, Department of Human Anatomy, Second Military Medical University of Chinese PLA, Shanghai 200433, China
  • About author:Han Chang-jie★, Studying for master’s degree, Department of Human Anatomy, Second Military Medical University of Chinese PLA, Shanghai 200433, China hanchangjieyourfirend @yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30970737*; the Key Foundation for Natural Science of Shanghai City, No. 08441900600*

PDF

571

被引次数

18

摘要：

背景：由于异体来源种子细胞的免疫排斥反应问题没有得到解决，使干细胞移植、组织工程局限于个体化治疗的范畴，而个体化治疗不适合战创伤性救治、不能在临床上广泛应用。脂肪干细胞不但具有成体干细胞的多向分化潜能，而且以其来源广、数量充足、易于扩增和免疫原性低等优点，使异源性组织工程器官的构建成为可能。
目的：对脂肪干细胞免疫学性质的研究进展作一总结。
方法：以“脂肪干细胞(Adipose-Derived Stem Cells，ADSCs)，免疫原性(immunogenicity)，免疫调节(immune regulation)，体内移植(implantation)”为关键词，应用计算机检索维普数据库，Pubmed数据库，Elsevier数据库相关文章。纳入与脂肪干细胞免疫学性质研究进展方面内容相关的文献，排除重复性研究。
结果与结论：共检索到26篇文献，排除无关重复的文献，保留17篇文献进行综述。目前对于脂肪干细胞免疫学性质的研究主要集中在脂肪干细胞表面免疫相关分子的表达、体外及体内免疫学性质的研究3个方面，这些研究从不同角度初步揭示了脂肪干细胞具有较低免疫原性和一定的免疫调节能力，有希望成为能用于同种异体干细胞移植及组织工程产品的种子细胞。

关键词: 脂肪干细胞, 免疫原性, 免疫调节, 体内移植, 排斥

Abstract:

BACKGROUND: Due to the immunological rejection caused by allogeneic cells, both of stem cell transplantation and tissue engineering are limited to the scope of individualized treatment and therefore not suitable for treatment of war trauma or extensive clinical use. Adipose-derived stem cells not only have the multiple differentiation potential, but also characterized by their broad sources, enough amount, easy-to-amplification and low immunogenicity. Thus, it is possible to construct heterologous tissue-engineered organs.
OBJECTIVE: To summarize progresses in the immunological characteristics of adipose-derived stem cells.
METHODS: A computer-based online search of VIP, Pubmed and Elsevier databases was performed for related articles with the key words of “adipose-derived stem cells, ADSCs, immunogenicity, immune regulation, implantation”. Articles related to immunological characteristics of adipose-derived stem cells were included, and repetitive studies were excluded.
RESULTS AND CONCLUSION: A total of 26 articles were collected, and 17 were included. At present, the immunological characteristics researches of adipose-derived stem cells mainly focus on the immunophenotype, in vitro and in vivo immunological properties, revealing that adipose-derived stem cells have low immunogenicity and immune regulation property, hopefully to be a candidate for allogeneic stem cell transplantation and tissue engineering products.

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