中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (27): 5090-5094.doi: 10.3969/j.issn.1673-8225.2010.27.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞在心肌梗死组织中定居的影响因素研究进展

贺  萍1，李  贺1，赵玉生2   

  1. 1武警医学院，天津市  300162；2解放军总医院老年心血管病研究所，北京市 100853
  • 出版日期:2010-07-02 发布日期:2010-07-02
  • 通讯作者: 赵玉生，教授，博士生导师，解放军总医院老年心血管病研究所，北京市 100853
  • 作者简介:贺萍★，女，1976年生，陕西省武功县人，汉族，武警医学院在读硕士，主要从事冠心病 的研究。 heping2008happy@163.com
  • 基金资助:

    国家高技术研究发展计划(863计划)。

Colonization factors of stem cells in myocardial infarction tissues

He Ping1, Li He1, Zhao Yu-sheng2   

  1. 1 Medical College of Chinese Pepole’s Armed Police Force, Tianjin  300162, China; 2 Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing  100853, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Zhao Yu-sheng, Professor, Doctoral supervisor, Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China zys3012002@yahoo.com
  • About author:He Ping★, Studying for master’s degree, Medical College of Chinese Pepole’s Armed Police Force, Tianjin 300162, China heping2008happy@163.com
  • Supported by:

    the National High Technology Research and Development Program of China*

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被引次数

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摘要：

背景：心肌细胞受损和缺如是心脏疾病中最常见的病理改变，而成年心肌细胞为高度分化的终末细胞，不能再生。因此，寻找一种有效促使心肌组织再生和修复的机制便成为当前研究的热点。
目的：就心肌组织工程的生物材料、能够促进干细胞归巢的细胞因子及中成药的研究现状做一综述，为干细胞更好的分化成心肌细胞的研究提供理论依据。
方法：以 “Stem Cells，Myocardial infarction，Tissue Engineering，Cytokines”为英文检索词；以“干细胞，心肌梗死，组织工程，细胞因子” 为中文检索词，检索Pubmed 数据库和维普数据库2002-01/2009-07相关文献。纳入与心肌再生、支架材料、心肌组织工程再血管化、细胞因子诱导干细胞分化及中药诱导干细胞分化相关文献；排除重复研究和Meta分析类文章。
结果与结论：干细胞移植治疗心肌梗死为临床治疗提供了诱人的前景。然而，一般情况下进入到外周循环血中的干细胞数极少，对坏死心肌组织的修复作用极为有限，存在“诱导分化”、“移植存活”、“动员归巢”3个环节的问题，组织工程、细胞因子及中成药联合干细胞移植，可为临床治疗心梗提供有效的办法，动员促进干细胞归巢，将可能解决一些目前的手段所不能解决的问题。目前干细胞的研究仍处于起步阶段，有很多问题尚待解决。

关键词: 心肌梗死, 干细胞, 定居, 影响因素, 归巢, 综述文献

Abstract:

BACKGROUND: Pathological changes, such as myocardial lesions or absence, are commonly in heart disease. The myocardial cells are terminal cells that can not regenerate. Thus, it is a hot focus to explore an effective mechanism for myocardial tissue regeneration and repair.
OBJECTIVE: To review the progress of myocardial tissue-engineered materials and the promotive effects of cytokine and Chinese patent medicine on stem cells homing, and to provide a theoretical basis for the study of stem cells differentiate into myocardial cells.
METHODS: Documents in the PubMed and VIP databases from January 2002 to July 2009 were searched by computer using key words of “Stem Cells, Myocardial infarction, Tissue Engineering and Cytokines” both in English and Chinese. Papers related to myocardial regeneration, scaffold materials, revascularization of myocardial tissue, and the effects of cytokine and Chinese patent medicine on stem cells differentiation were included. Repetitive research or Meta analysis was excluded.
RESULTS AND CONCLUSION: Stem cell transplantation has shown attractive prospect in the treatment of myocardial infarction. However, generally, stem cells could seldom enter the peripheral circulation, and it was very limited to repair myocardial necrotic tissue. There were three key issues: induction and differentiation, transplantation and survival, mobilization and homing. Tissue engineering, cytokine, Chinese patent medicine, combined with stem cells transplantation, could be the effective treatment for myocardial infarction. Such problems unsolvable by far would be tackled by mobilization and homing of stem cells. But the research of stem cells just begin now, many puzzles need to be solved.

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