中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (27): 5081-5084.doi: 10.3969/j.issn.1673-8225.2010.27.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

肺干细胞及其标记物：来源定位与标记难度

姜亦瑶1，杜振宗1，王海永1，张  璋2   

  1. 桂林医学院附属医院，1心胸外科，2放疗科，广西壮族自治区桂林市 541001
  • 出版日期:2010-07-02 发布日期:2010-07-02
  • 通讯作者: 杜振宗，硕士生导师，桂林医学院附属医院心胸外科，广西壮族自治区桂林市 541001 duzhenzong@ sina.com
  • 作者简介:姜亦瑶★，男，1984年生，黑龙江省哈尔滨市人，汉族，桂林医学院附属医院心胸外科在读硕士，主要从事干细胞和组织工程在心胸外科的应用研究。 Jiangyiyao0309@sina.com

Lung stem cells and the markers: Source localization and labeled difficulty

Jiang Yi-yao1, Du Zhen-zong1, Wang Hai-yong1, Zhang Zhang2   

  1. 1 Department of Cardiothoracic Surgery, 2 Department of Radiotherapy, Hospital Affiliated to Guilin Medical College, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Du Zhen-zong, Master’s supervisor, Department of Cardiothoracic Surgery, Hospital Affiliated to Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China duzhenzong@sina. com
  • About author:Jiang Yi-yao★, Studying for master’s degree, Department of Cardiothoracic Surgery, Hospital Affiliated to Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China Jiangyiyao0309@ sina.com

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摘要：

背景：肺干细胞在特定条件可分化为功能性肺组织。近年来，对于肺干细胞来源及其标记物的研究取得了相应的进展。
目的：文章从内源性肺干细胞、外源性肺干细胞的角度回顾肺干细胞的来源，并以Sca-1、ABCG2/Bcrp1、滞留细胞标记分子、细胞表面分子、细胞角蛋白、CCSP为代表总结可能的肺干细胞标记物。
方法：应用计算机检索中国期刊全文数据库和Pubmed数据库相关文献，检索词分别为“肺干细胞，标记物”和“lung stem cell, markers”，语言分别设定为中文和英文，共检索到79篇文章，阅读文题和摘要进行筛选，选择具有原则性，论点论据可靠且分析全面的与肺干细胞及其标记物密切相关的文章，排除重复研究及质量较差的文献，最后纳入31篇进行总结综述。
结果与结论：肺组织的复杂性决定了定位肺干细胞来源以及发现肺干细胞标记物的难度，目前仍有许多未知的领域有待进一步探索。相信随着实验技术的日益完善，会有更多的新发现，肺干细胞在临床应用上具有广阔的前景。

关键词: 内源性肺干细胞, 外源性肺干细胞, 标记物, 研究进展, 文献综述

Abstract:

BACKGROUND: In the definite condition, lung stem cells can differentiate into the functional lung tissue. In recent years, the research about the origin of lung stem cells and its markers has gained homologous progress.
OBJECTIVE: To review the source of lung stem cells in the perspective of endogenous and exogenous lung stem cells, and to summarize the possible lung stem cell markers in representation of Sca-1, ABCG2/Bcrp1, residual cell marker molecules, cell surface molecules, cytokeratin, and CCSP.
METHODS: A computer-based online search of China Journal Full-text Database and Pubmed was performed for articles and reviews in Chinese and English. The key words were “lung stem cells, markers”. A total of 79 articles were retrieved, and screened following reading titles and abstracts. Literatures about lung stem cells and markers were included. Repetitive articles with poor quality were excluded. Finally, 31 literatures were included.
RESULTS AND CONCLUSION: The complexity of the lung tissue determined that the difficulty which was finding out the origin of lung stem cells and its markers. Currently, there are still many further explorations of the unknown fields. With the development of the experimental technique, there will be more and more new discovery. Lung stem cells will have a broad prospect in the clinical application.

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