中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (24): 4445-4448.doi: 10.3969/j.issn.1673-8225.2010.24.017

• 组织构建与生物力学 tissue construction and biomechanics • 上一篇    下一篇

动脉粥样硬化模型动物脑血管的拉伸力学特性

于  波1，孙长江1，权铁刚1，许东辉1，马洪顺2   

  1. 吉林大学，1中日联谊医院，吉林省长春市 130031，2南岭校区工程力学系，吉林省长春市  130022
  • 出版日期:2010-06-11 发布日期:2010-06-11
  • 通讯作者: 马洪顺，教授，主要从事生物医学工程方面的研究。吉林大学南岭校区工程力学系，吉林省长春市 130022 mahs@jlu.edu. cn
  • 作者简介:于 波★，男，1969年生，吉林省长春市人，硕士，主治医师，主要从事心血管内科临床与生物医学工程方面的研究。 mahs@jlu.edu.cn

Tensile mechanical properties of middle cerebral artery in an atherosclerosis model

Yu Bo1, Sun Chang-jiang1, Quan Tie-gang1, Xu Dong-hui1, Ma Hong-shun2   

  1. 1 China-Japan Union Hospital, 2 Department of Engineering Mechanics, Nanling Campus, Jilin University, Changchun  130031, Jilin Province, China
  • Online:2010-06-11 Published:2010-06-11
  • Contact: Ma Hong-shun, Professor, Department of Engineering Mechanics, Nanling Campus, Jilin University, Changchun 130031, Jilin Province, China mahs@jlu.edu.cn
  • About author:Yu Bo★, Master, Attending physician, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin Province, China

PDF

608

被引次数

12

摘要：

背景：脑动脉粥样硬化和脑出血的防治有必要了解正常和动脑粥样硬化模型大鼠大脑中动脉的力学特性，但以往的研究对象多为正常人尸体与正常动物脑动脉的力学特性。
目的：比较正常和动脉粥样硬化动物模型大脑中动脉的拉伸力学特性。
方法：SD大鼠随机分为正常对照组和模型组。模型组大鼠建立动脉粥样硬化模型。取2组大鼠的大脑中动脉以电子万能试验机对其进行5 mm/min拉伸载荷实验，观察2组大鼠脑动脉最大载荷、最大位移、最大应力以及最大应变差异及血管应力-应变关系。
结果与结论：动脉粥样硬化大鼠脑动脉血管拉伸最大载荷、最大应力、最大位移及最大应变均较正常大鼠明显降低(P < 0.05)，大鼠脑动脉血管应力-应变曲线是以指数关系变化的。因此，说明动脉粥样硬化模型大鼠大脑中动脉和正常对照组大鼠大脑中动脉具有不同的拉伸力学特性，脑动脉粥样硬化大鼠动脉血管不能像正常大鼠脑血管一样再作较大的伸展。

关键词: 大鼠, 动脉粥样硬化, 模型, 大脑中动脉, 一维拉伸, 生物力学

Abstract:

BACKGROUND: It is necessary to understand the mechanical properties of middle cerebral artery of normal or atherosclerotic rats in order to prevent and cure atherosclerosis and cerebral hemorrhage. However, most previous studies focus on mechanical properties of normal human corpses and animals.
OBJECTIVE: To compare the tensile mechanical properties of middle cerebral artery between normal and atherosclerotic rats.
METHODS: Sprague Dawley rats were randomly divided into the control and model groups. The atherosclerotic models were prepared in the model group. Then rats were performed 5 mm/min tensile test at electron Shimadzu universal testing machine. The experimental data, such as maximum load, maximum displacement, maximum stress, maximum strain, as well as the stress-strain relationship were observed. 
RESULTS AND CONCLUSION: Compared with the control group, the maximum load, maximum displacement, maximum stress, and maximum strain of the model group were obviously decreased (P < 0.05). The stress-strain curve changed in an exponential relationship. Accordingly, the middle cerebral artery of atherosclerotic rats exhibits distinct tensile mechanical properties from normal rats, which can not extent greatly. 

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