中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (22): 4027-4031.doi: 10.3969/j.issn.1673-8225.2010.22.009

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

磁刺激神门穴脑电信号诱发电位分析及源定位

耿跃华，徐桂芝，于洪丽，陈亚静，李文文   

  1. 河北工业大学河北省电磁场与电器可靠性重点实验室，天津市  300130
  • 出版日期:2010-05-28 发布日期:2010-05-28
  • 通讯作者: 徐桂芝，博士，教授，河北工业大学河北省电磁场与电器可靠性重点实验室，天津市 300130 gzxu@hebut.edu.cn
  • 作者简介:耿跃华☆，女，1978年生，天津市人，汉族，河北工业大学在读博士，讲师，主要从事生物医学信号处理方面的研究。gyh@hebut.edu.cn
  • 基金资助:

    河北省自然科学基金资助项目(E2008000053，E2009000049)；国家自然科学基金(50877023)资助项目；河北省科技支撑计划项目(09276103D-4)。

Evoked potential analysis and dipole localization by magnetic stimulation on acupoint of Shenmen (HT 7) acupoint

Geng Yue-hua, Xu Gui-zhi, Yu Hong-li, Chen Ya-jing, Li Wen-wen   

  1. Key Laboratory of Electro-Magnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin   300130, China
  • Online:2010-05-28 Published:2010-05-28
  • Contact: Xu Gui-zhi, Doctor, Professor, Key Laboratory of Electro-Magnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300130, China gzxu@hebut.edu.cn
  • About author:Geng Yue-hua☆, Studying for doctorate, Lecturer, Key Laboratory of Electro-Magnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300130, China gyh@hebut.edu.cn
  • Supported by:

    the Natural Science Foundation of Hebei Province, No. E2008000053*, E2009000049*; the National Natural Science Foundation of China, No. 50877023*; Science & Technology Pillar Program of Hebei Province, No. 09276103D-4*

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472

被引次数

3

摘要：

背景：磁刺激技术是一种新型生物刺激技术，鉴于其使用方便且无痛无创，所以可以采用磁刺激技术刺激穴位替代针刺或电刺穴位。脑电信号可以反映大脑皮质神经的兴奋状态，所以磁刺激与神经相关的神门穴并测量与分析其脑电信号可以研究磁刺激穴位的作用与效果。
目的：以不同频率磁刺激刺激肢体神门穴，观察在4种不同状态下脑电信号的诱发电位及其偶极子源定位。
方法：选择健康右利手男性6名，女性4名，年龄20~30岁，既往无神经、精神系统病史，实验期间被试保持闭眼静息。用3，1，0.5 Hz 3种不同频率的磁刺激刺激被试右手神门穴。每种频率的刺激实验分4组，第1组为静息实验，第2组为磁刺激实验，第3组为假刺激实验，第4组为假穴实验。观察4种状态下诱发电位的幅值与潜伏期，诱发电位偶极子源定位冠状面、矢状面和轴状面图。
结果与结论：0.5，1 Hz磁刺激实验4组状态的脑电信号均无明显诱发电位。3 Hz磁刺激安静状态与假刺激状态无诱发电位，磁刺激状态主要诱发产生P300成分，体感诱发电位和其他诱发电位得到抑制；假穴状态除产生P300，另外产生明显体感诱发电位和其他诱发电位。对刺激状态和假穴状态的脑电信号进行脑源定位，经过主成分分析确定有两个偶极子源，磁刺激状态偶极子源定位于额颞区，假穴状态偶极子分布较分散。说明采用磁刺激人体神门穴对脑电信号有明显抑制，与进行针刺或电刺激同样具有调节神经功能的作用。

关键词: 磁刺激, 诱发电位, 偶极子源定位, 神门穴, 数字化医学

Abstract:

BACKGROUND: Magnetic stimulation is a new kind of non-invasive and painless stimulation technique, which can substitute acupuncture or electric acupuncture. Electroencephalogram (EEG) can show the active state of brain nerves, thus, magnetic stimulating acupoint related to brain nerves, measuring and analyzing the EEG signals can study the effect of magnetic stimulation on acupoint.
OBJECTIVE: To stimulate acupoint of Shenmen (HT 7) using magnetic stimulation with different frequencies, in addition, to study the evoked potentials (EPs) and dipole localization of EEG at 4 states.
METHODS: A total of 6 male and 4 female volunteers were selected, aged 20-30 years. They had no experimental experience or formal psychiatric history. They kept eyes closing during the experiment. Magnetic stimulate acupoint of Shenmen (HT 7) at right hand of volunteers in frequencies of 3 Hz, 1 Hz and 0.5 Hz. The experiment of every frequency was divided into 4 tests: quiet, magnetic stimulation, mock stimulation and mock point. The amplitude and latency of EPs at 4 states and the coronal, sagittal and axial plane of dipole localization of EPs were observed.
RESULTS AND CONCLUSION: The 4-states experiments of 0.5 Hz and 1 Hz had no obvious EPs. Quiet state and mock stimulation state of 3 Hz had no obvious EPs. Magnetic stimulation state induced EP of P300, somatosensory evoked potentials and other potentials were restrained. Mock point induced P300 and also induced obvious SEPs and other potentials. Dipole localized to magnetic stimulation state and mock point state. It can be defined that there are two dipoles by Principal Components Analysis PCA. The dipoles of magnetic stimulation state located in frontotemporal area, the dipoles of mock point state were dispersed. The EEG signals were obviously restrained when magnetic stimulate on acupoint of Shenmen (HT 7). It also has the effect of adjusting neural function the same as acupuncture.

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