中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (16): 2999-3002.doi: 10.3969/j.issn.1673-8225.2010.16.037

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

冠状动脉支架材料学特性、生物相容性与置入后并发症

胡  蓉1，王亚莉2   

  1. 1巴中市中心医院眼科，四川省巴中市 636000；2川北医学院附属医院胸心外科，四川省南充市   637000
  • 出版日期:2010-04-16 发布日期:2010-04-16
  • 通讯作者: 王亚莉，副主任护师，川北医学院附属医院胸心外科，四川省南充市 637000 yaliwangweiyun@163.com
  • 作者简介:胡 蓉，1970年生，四川省巴中市人，汉族，川北医学院毕业，主管护师，主要从事临床护理方面的研究。1282608494@qq.com

Material features, biocompatibility of coronary artery stent and related complications following implantation

Hu Rong1, Wang Ya-li2   

  1. 1 Department of Ophthalmology, Central Hospital of Bazhong, Bazhong  636000, Sichuan Province, China; 2 Department of Cardiothoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong  637000, Sichuan Province, China
  • Online:2010-04-16 Published:2010-04-16
  • Contact: Wang Ya-li, Associate chief nurse, Department of Cardiothoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China yaliwangweiyun@163.com
  • About author:Hu Rong, Nurse-in-charge, Department of Ophthalmology, Central Hospital of Bazhong, Bazhong 636000, Sichuan Province, China 1282608494@qq.com

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543

被引次数

5

摘要：

目的：探讨冠状动脉支架的材料学特性、生物相容性及其置入后并发症的发生及处理情况。
方法：由第一作者采用电子检索的方式，在中国期刊全文数据库(CNKI：2000/2009)中进行文献检索，语言设定为中文；在Medline数据库(Pubmed: 2000/2009)中进行文献检索，语言设定为英文。检索词为“冠状动脉支架，材料，生物相容性，并发症”。排除Meta分析及重复性研究，最后共纳入16篇文章。
结果：支架材料的选择在减少机体炎症反应的强度和持续时间，减少支架置入后血管内再狭窄的发生起着重要的作用，作为人体医用材料，对支架各方面性能都提出了很高的要求，包括可靠的扩张性和力学持久性、良好的柔韧性和几何稳定性、尽可能小的外径，优异的血液相容性和耐蚀性，而支架上述特性都依赖于材料的力学和物理特性。
结论：药物涂层支架、药物洗脱支架的研究降低了支架置入后血管内再狭窄率，具备优良特性的生物可降解支架也日益受到重视。在置入心血管支架治疗冠状动脉粥样硬化性心脏病时，除提高血管开通的成功率外，还应密切注意并尽量减少并发症的发生。

关键词: 冠状动脉支架, 材料, 生物相容性, 并发症, 再狭窄

Abstract:

OBJECTIVE: To explore the material features and biocompatibility of coronary artery stent and related complications following implantation.
METHODS: The databases of CNKI and Medline were searched by the first author using key words of “coronary artery stent, material, biocompatibility and complications” both in English and Chinese. Meta analysis or repetitive studies were excluded, and 16 papers were included in this analysis.
RESULTS: Stent materials play an important role in reducing inflammatory reaction and restenosis following stent implantation. As a medical material for humans, the features of stent should be meet the requirements of reliable distensibility, mechanical persistence, good flexibility and geometrical stability, possible small diameter, excellent blood compatibility, as well as good corrosion resistance. All of these depended on the mechanical and physical features of materials.
CONCLUSION: The study of drug-coating stent and drug-eluting stent reduced the restenosis rates following implantation, and the biodegradable stent also attracted more attention. When treating coronary heart disease with cardiovascular stent, the complications should be avoided except consideration of the successful rate of reperfusion.

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