中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (15): 2805-2809.doi: 10.3969/j.issn.1673-8225.2010.15.035

• 组织构建综述 tissue construction review • 上一篇    下一篇

脑源性生长因子与神经损伤的修复及再生

陈保国，黄渭清   

  1. 中国医学科学院北京协和医院整形外科，北京市   100032
  • 出版日期:2010-04-09 发布日期:2010-04-09
  • 通讯作者: 黄渭清，教授，硕士生导师，中国医学科学院北京协和医院整形外科，北京市 100032
  • 作者简介:陈保国★，男，1985年生，安徽省天长市人，汉族，中国医学科学院北京协和医院在读硕士，医师，主要从事外周神经的创伤修复研究。 chenbaoguo861028@126.com

Brain-derived neurotrophic factor and repair and regeneration of injured nerves

Chen Bao-guo, Huang Wei-qing   

  1. Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing   100032, China
  • Online:2010-04-09 Published:2010-04-09
  • Contact: Huang Wei-qing, Professor, Master’s supervisor, Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100032, China
  • About author:Chen Bao-guo★, Studying for master’s degree, Physician, Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100032, China chenbaoguo861028@126.com

PDF

550

被引次数

33

摘要：

背景：脑源性生长因子具有促进神经元生长存活，引导轴突延伸塑型的作用。周围神经损伤后的再生和髓鞘形成需要内源性脑源性神经生长因子。
目的：归纳总结脑源性生长因子的研究现状。
方法：以中文检索词“神经再生；脑源性生长因子”和英文检索词“nerve，regeneration，BDNF”检索2000-01/2009-08中国期刊全文数据库和Pubmed数据库。纳入具有原创性、论点论据可靠的试验文章，观点明确，分析全面的文章，及文献主题与此课题关系紧密的文章。排除重复性研究和综述文章。
结果与结论：神经损伤后在髓鞘形成过程中脑源性神经生长因子通过高亲和力Trk受体和低亲和力受体P75NTR促进髓鞘形成。与神经生长因子在周围靶组织合成不同，脑源性神经生长因子主要在中枢神经系统中合成，但当周围神经受损后其mRNA表达增多，大量的实验表明正常周围神经的许旺细胞同样有少量脑源性神经生长因子表达。现在人们通过将脑源性神经生长因子基因通过病毒介导转染干细胞后移植到神经损伤区域治疗疾病，有望成为新的治疗方法。

关键词: 脑源性生长因子, 神经再生, 综述文献, 神经组织工程, 神经再生

Abstract:

BACKGROUND: Brain-derived neurotrophic factor (BDNF) can promote neuron development and survival, and axon prolongation and modeling. Peripheral nerve regeneration and myelin formation after injury need endogenous BDNF.
OBJECTIVE: To summarize research status of BDNF.
METHODS: A computer-based online search of CNKI and Pubmed databases was performed for articles published between January 2000 and August 2009 with the key words “nerve regeneration, BDNF” in Chinese and English. Articles with creativity, reliable evidence and close correlation with the content were included. Repetitive and review articles were excluded.
RESULTS AND CONCLUSION: BDNF boosts myelin formation by binding to high-affinity receptor Trk and low-affinity receptor p75NTR.Compared to nerve growth factor (NGF) synthesized in surrouding target tissues, BDNF is mainly synthesized in central nervous system. However, BDNF mRNA is expressed increasingly following peripheral nerve injury. Various of experiments have demonstrated that normal peripheral Schwann cells can express a little BDNF. Currently, BDNF gene has been mediated through virus, transfected into stem cells, which can be transplanted into injured nerve sites.

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