中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (13): 2467-2470.doi: 10.3969/j.issn.1673-8225.2010.13.046

• 骨科植入物 orthopedic implant • 上一篇    

丹红注射液对冠状动脉支架置入患者血管内皮功能的影响

梁  红   

  1. 沈阳医学院沈洲医院内科，辽宁省沈阳市  110002
  • 出版日期:2010-03-26 发布日期:2010-03-26
  • 作者简介:梁 红★，女，1971年生，山东省黄县人，汉族，1994年辽宁中医药大学毕业，硕士，副主任医师，主要从事中医药与介入研究。

Danhong injection effects on vascular endothelial function in patients undergoing coronary artery stent implantation

Liang Hong   

  1. Department of Internal Medicine, Shenzhou Hospital, Shenyang Medical College, Shenyang   110002, Liaoning Province, China
  • Online:2010-03-26 Published:2010-03-26
  • About author:Liang Hong★, Master, Associate chief physician, Department of Internal Medicine, Shenzhou Hospital, Shenyang Medical College, Shenyang 110002, Liaoning Province, China tcmqq@qq.com

PDF

369

被引次数

14

摘要：

背景：众多研究证实丹参能抑制中性粒细胞的黏附、聚集及氧自由基的产生，具有活血化瘀的疗效，但目前对于其保护血管内皮以及抗血栓形成具体机制，尤其是在冠状动脉支架置入后作用机制的研究很少。
目的：观察丹红注射液对急性冠脉综合征患者冠状动脉支架置入前后血管内皮功能的影响。
方法：采用随机对照方法将60例急性冠脉综合征患者分为2组，常规治疗组在冠状动脉支架置入后给予常规药物治疗；丹红组在冠状动脉支架置入后给予常规药物治疗基础上加用丹红注射液20 mL/d，疗程10 d。支架置入前后及丹红治疗前后测定内皮依赖性血流介导的血管舒张反应、血浆内皮素、血栓烷B2、6-酮-前列腺素水平，双重评价其血管内皮功能；同时观察两组患者近期预后。
结果与结论：与支架置入前比较，支架置入后两组患者血浆内皮素、血栓烷B2均明显提高，6-酮-前列腺素水平明显下降(P < 0.05)。与支架置入后比较，两组治疗后血浆内皮素、血栓烷B2均明显降低(P < 0.05，P < 0.01)；内皮依赖性血流介导的血管舒张反应、6-酮-前列腺素明显提高(P < 0.05，P < 0.01)，丹红组更明显(P < 0.05)。住院期间丹红组心血管事件发生较常规治疗组略有下降，但差异无显著性意义(P > 0.05)。结果表明丹红注射液可显著改善支架置入急性冠脉综合征患者血管内皮功能，使血管舒张，改善供血，抑制血小板聚集，且有改善近期预后的倾向。

关键词: 介入治疗, 急性冠脉综合征, 血管内皮功能, 丹红注射液, 支架置入, 心血管植入物

Abstract:

BACKGROUND: Numerous studies have shown that Danshen Root can suppress adhesion and aggregation of neutrophils as well as production of oxygen free radical, can activate blood circulation to dissipate blood stasis. However, there are few studies about precise mechanisms underlying protection of vascular endothelium and anti-thrombosis, especially concerning the mechanism of action following coronary artery stent implantation.
OBJECTIVE: To investigate the influence of Danhong injection on vascular endothelial function before and after coronary artery stent implantation in patients with acute coronary syndrome (ACS).
METHODS: A total of 60 ACS patients were randomly assigned to two groups. The patients in the conventional treatment group were subjected to conventional drug treatment following coronary artery stent implantation. The patients in the Danhong injection group received conventional drug treatment and Danhong injection (20 mL/d) following coronary artery stent implantation. The treatment course was 10 days. Before and after implantation as well as before and after Danhong injection treatment, endothelium-derived blood flow-mediated vasodilation, plasma endothelin, thromboxane B2, 6-keto-prostaglandin levels were determined, and the vascular endothelial function were evaluated. Simultaneously, short-term prognosis was observed in patients of both groups.
RESULTS AND CONCLUSION: Plasma endothelin and thromboxane B2 levels were significantly increased, but 6-keto-prostaglandin levels were significantly decreased following stent implantation in patients of both groups compared with that before implantation (P < 0.05). Plasma endothelin and thromboxane B2 levels were significantly reduced, but endothelium-derived blood flow-mediated vasodilation and 6-keto-prostaglandin levels were significantly increased in both groups following treatment compared with that following implantation (P < 0.05, P < 0.01), especially in the Danhong injection group (P < 0.05). During hospitalization, the incidences of cardiovascular events were diminished in the Danhong injection group compared with conventional drug treatment group (P > 0.05). Results suggested that Danhong injection significantly improves vascular endothelial function, induces vasodilatation, improves blood supply, inhibits platelet aggragation, and shows the tendency of ameliorating short-term prognosis.

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