Finite element analysis and in vitro biomechanical experiment of new domestic lumbar
interspinous process distraction device

doi:10.3969/j.issn.2095-4344.2526

Abstract

Abstract:

BACKGROUND: The non-fusion system of lumbar interspinous process distraction device provides a new treatment option for lumbar degenerative diseases. However, at present, the clinical application and research of lumbar interspinous process distraction device are reported insufficiently in China, especially for the domestic lumbar interspinous process distraction device.

OBJECTIVE: To verify the scientific nature and effectiveness of the new domestic lumbar interspinous process distraction device through finite element analysis and in vitro biomechanical experiment of goat lumbar spine.

METHODS: (1) Finite element analysis of new domestic lumbar interspinous process distraction device: L₂-L₅ three-dimensional model of vertebral body was established based on normal adult lumbar CT data. From then on, new domestic lumbar interspinous process distraction device model, new lumbar interspinous process distraction device model of lumbar non fusion system were successively built. The mechanical conditions were given under the physiological conditions of lumbar spine. Biomechanical analysis was carried out before and after the new domestic lumbar interspinous process distraction device was implanted. (2) In vitro biomechanical analysis of new domestic lumbar interspinous process distraction device: the lumbar vertebrae (L₁-L₅) of 24 adult male goats were obtained, and the new domestic lumbar interspinous process distraction device was implanted between the L₃_-₄ spinous process. Before and after the placement of the lumbar interspinous process distraction device, the lumbar motion range and the pressure of the intervertebral disc under the flexion, extension, lateral bending and rotation of the lumbar specimens were detected.

RESULTS AND CONCLUSION: (1) After the new lumbar interspinous process distraction device was implanted, the motion range and the pressure of the intervertebral disc of responsible segment were reduced, while the adjacent segments’ mobility and the pressure of the intervertebral disc were almost unaffected. It was theoretically verified that the new domestic lumbar interspinous process distraction device could provide the biomechanical basis for the treatment of the lumbar degenerative diseases, and contribute to the theoretical reference for the prevention of the clinical diseases. (2) In the state of extension, the motion range of L₃_-₄ vertebral body after implanting the new lumbar interspinous process distraction device was significantly lower than that before implantation (P < 0.05). There was no significant difference between L₂_-₃ and L₄_-₅ vertebral body after implanting the new lumbar interspinous process distraction device and that before implantation (P > 0.05). In the state of flexion, lateral bending and rotation, there was no significant difference between L₂_-₃, L₃_-₄ and L₄_-₅ vertebral body after implanting the lumbar interspinous process distraction device and that before implantation (P > 0.05). In the state of extension, the pressure of intervertebral disc after L₃_-₄ vertebral body implantation was significantly lower than that before implantation (P < 0.05). There was no significant difference between L₂_-₃ and L₄_-₅ vertebral body implantation and that before implantation (P > 0.05). In the state of flexion, lateral bending and rotation, there was no significant difference between L₂_-₃, L₃_-₄ and L₄_-₅ vertebral body implantation and that before implantation (P > 0.05). (3) The results showed that the scientific nature and validity of the new domestic lumbar interspinous process distraction device was verified by three-dimensional finite element analysis and in vitro animal lumbar specimens experiment, which provided a strong basis for the animal experiment, clinical experiment, clinical application and clinical production of the new domestic lumbar interspinous process distraction device.

Key words: lumbar interspinous process distraction device, finite element analysis, biomechanics, adjacent segment degeneration, lumbar degenerative disease, lumbar vertebra, biomechanics, internal fixator, tissue engineering

CLC Number:

Wang Baodong, Hou Jichun, He Renke, Cao Yang. Finite element analysis and in vitro biomechanical experiment of new domestic lumbar interspinous process distraction device [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(12): 1897-1904.

Figures/Tables 6

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