Correlation between complete denture relines and serum bone turnover markers in elderly edentulous patients with osteoporosis

doi:10.3969/j.issn.2095-4344.2017.22.012

Abstract

Abstract:

BACKGROUND: The residual alveolar ridge in edentulous patients with osteoporosis always presents with a poor shape, which increases the difficulty in complete denture restoration. Until now, there are no predictors for residual alveolar ridge resorption or guidelines on the frequency of denture relines.

OBJECTIVE: To investigate the correlation between the frequency of complete denture relines and serum bone turnover markers, osteocalcin (OC) and cross-linked carboxy-terminal telopeptide of type I collagen (CTX), in elderly edentulous patients with osteoporosis, in order to provide reference for complete denture repair.

METHODS: According to inclusion criteria, 50 elderly edentulous patients with osteoporosis who had complete dentures were recruited in the study randomly. The frequency of complete denture relines was surveyed by related questionnaire and medical record, and the serum OC and CTX levels were detected by electrochemiluminescence immunoassay. Related data were analyzed statistically via Pearson correlation analysis.

RESULTS AND CONCLUSION: It showed a strong positive correlation between the frequency of complete denture relines and the serum OC level (r=0.517, P < 0.01). No significant correlation between relines frequency and the serum CTX level was observed (r=0.278, P=0.051 > 0.05), but it showed a similar tendency between them. These findings indicate that to detect the levels of serum bone turnover markers may be conducive to evaluating curative effect of complete dentures in elderly edentulous patients with osteoporosis as well as to making subsequent diagnostic and therapeutic strategies.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Osteoporosis, Dentures, Osteocalcin, Tissue Engineering

CLC Number:

R318

Yu Tian-hao, Jia Xing-ya, Xue Yan-qing, Zhan De-song, Yan Xu.

Correlation between complete denture relines and serum bone turnover markers in elderly edentulous patients with osteoporosis

[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(22): 3513-3518.

Figures/Tables 5

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