中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (29): 5459-5462.doi: 10.3969/j.issn.1673-8225.2011.29.034

• 生物材料综述 biomaterial review • 上一篇    下一篇

纳米疫苗黏膜免疫传递系统的特征

黄婷婷1，侯志勇2，张晓艳1，陈  刚1，蒿连微1，赵  凯1   

  1. 1黑龙江大学，生命科学学院，微生物黑龙江省高校重点实验室，黑龙江省哈尔滨市 150080
    2解放军第211医院，黑龙江省哈尔滨市 150080
  • 收稿日期:2011-01-26 修回日期:2011-03-14 出版日期:2011-07-16 发布日期:2011-07-16
  • 通讯作者: 赵凯，博士，教授，黑龙江大学，生命科学学院，微生物黑龙江省高校重点实验室，黑龙江省哈尔滨市 150080 zk395@yahoo.com.cn
  • 作者简介:黄婷婷★，女，1985年生，广西壮族自治区贺州市人，硕士，主要从事疫苗黏膜免疫传递系统方面的研究。
  • 基金资助:

    国家自然科学基金项目(31072119)；哈尔滨市科技攻关计划项目(2009AA6CN125)、哈尔滨市科技创新人才研究专项资金项目(2010RFQXN091，2011RFQXN039)；黑龙江大学高层次人才(创新团队)支持计划(hdtd2010-17)；博士后落户黑龙江科研启动资助金项目(LBH-Q07109)。

Characterization of vaccine nanoparticles mucosal delivery system

Huang Ting-ting1, Hou Zhi-yong2, Zhang Xiao-yan1, Chen Gang1, Hao Lian-wei1, Zhao Kai1   

  1. 1Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin 150080, Heilongjiang Province, China
    2People’s Liberation the 211 Hospital Chinese PLA, Harbin  150080, Heilongjiang Province, China
  • Received:2011-01-26 Revised:2011-03-14 Online:2011-07-16 Published:2011-07-16
  • Contact: Zhao Kai, Doctor, Professor, Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin 150080, Heilongjiang Province, China zk395@yahoo.com.cn
  • About author:Huang Ting-ting★, Master, Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin 150080, Heilongjiang Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31072119*; the Science and Technology Development Program of Harbin, No. 2009AA6CN125*; the Science and Technology Innovation Talent Program of Harbin, No. 2010RFQXN091*,2011RFQXN039*; High Level Talent (Innovation Team) Supporting Plan of Heilongjiang University, No. hdtd2010-17*; the Scientific Research Program for Heilongjiang Postdoctors, No. LBH-Q07109*

PDF

460

被引次数

3

摘要：

背景：纳米粒系统作为一种疫苗的黏膜免疫递送系统，具有保护抗原、简化接种程序、增强免疫效果等优点。
目的：对黏膜免疫递送系统的特点、纳米疫苗黏膜免疫传递系统及其应用研究进展进行综述。
方法：应用计算机检索CNKI、Sciencedirect、Pubmed数据库中1997-01/2010-06关于纳米疫苗黏膜免疫的文章，在标题和摘要中以“纳米粒，疫苗，黏膜免疫，PLGA，壳聚糖”或“nanoparticles，vaccine，mucosal immune delivery，PLGA，chitosan”为检索词进行检索。选择文章内容与黏膜免疫、纳米粒疫苗有关者，同一领域文献则选择近期发表或发表在权威杂志文章。初筛得到168篇文献，最后选择关于纳米疫苗黏膜免疫传递系统的48篇文献进行综述。
结果与结论：纳米疫苗黏膜免疫传递系统所使用的生物材料具有生物可降解性、生物相容性、低毒性等良好的生物学特性，且易制成不同途径给药的载体，能增强免疫效果，使药物或DNA在体内能长效表达和释放，对结合的抗原和DNA有保护作用等特点，显著扩大了其应用范围。

关键词: 纳米粒, 疫苗, 黏膜免疫, 聚乳酸-乙醇酸共聚物, 壳聚糖

Abstract:

BACKGROUND: As a vaccine mucosal delivery system, nanoparticle system has many advantages, including antigen protection, simplified immune procedure and facilitated transport of the antigen.
OBJECTIVE: To introduce the characteristics of mucosal delivery system, overview the application and prospect of the vaccine mucosal delivery technologies based on nanoparticles.
METHODS: Using the database of CNKI, Sciencedirect, and Pubmed to search the related articles about vaccine nanoparticles mucosal delivery system published between January 1997 and June 2010 with key words “nanoparticles, vaccine, mucosal immune delivery, PLGA, chitosan” in Chinese and English. Related articles were selected, which were published in authoritative journals in the same field. There were 168 articles after the initial survey, and 48 articles related vaccine nanoparticles mucosal delivery system were included.
RESULTS AND CONCLUSION: Biomaterials used in vaccine nanoparticles mucosal delivery system include hydrophilicity and hydrophobicity nanoparticles, which have good biological features, such as biodegradability, low toxicity, and antigen protection. Moreover, they can be modified and used as carriers for different drugs to enhance immunity and allow long-term expression and release of drugs or DNA in vivo. They significantly enlarge application range of vaccine nanoparticles mucosal delivery system.

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