中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (27): 5091-5095.doi: 10.3969/j.issn.1673-8225.2011.27.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

Hedgehog信号通道与相关干细胞增殖与分化的研究进展

王  莉1，杨志云2，王宪波2   

  1. 1北京中医药大学，北京市   100029
    2首都医科大学附属北京地坛医院中西医结合中心，北京市   100017
  • 收稿日期:2011-03-30 修回日期:2011-05-19 出版日期:2011-07-02 发布日期:2011-07-02
  • 通讯作者: 杨志云，博士，副主任医师，首都医科大学附属北京地坛医院中西医结合中心，北京市 100017 yangzhiyun6@yahoo.com.cn 并列通讯作者：王宪波，博士，主任医师，首都医科大学附属北京地坛医院中西医结合中心，北京市 100017 wangxianbo638@163.com
  • 作者简介:王莉★，女，1986年生，云南省红河州泸西县人，汉族，2011年北京中医药大学毕业，硕士，主要从事肝病基础与临床研究。
  • 基金资助:

    国家自然科学基金面上项目(30873423)。

Research development of Hedgehog signal pathway and proliferation and differentiation of related stem cells

Wang Li 1, Yang Zhi-yun2, Wang Xian-bo2   

  1. 1Beijing University of Chinese Medicine, Beijing  100029, China
    2Center for Integrated Traditional and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing  100017, China
  • Received:2011-03-30 Revised:2011-05-19 Online:2011-07-02 Published:2011-07-02
  • Contact: Yang Zhi-yun, Doctor, Associate chief physician, Center for Integrated Traditional and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100017, China yangzhiyun6@yahoo.com.cn Correspondence to: Wang Xian-bo, Doctor, Chief physician, Center for Integrated Traditional and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100017, China wangxianbo638@163.com
  • About author:Wang Li★, Master, Beijing University of Chinese Medicine, Beijing 100029, China
  • Supported by:

    the General Program of National Natural Science Foundation of China, No. 30873423*

PDF

365

摘要：

背景：Hedgehog蛋白为成形素蛋白，其相关信号通道参与胚胎发育和成体组织再生。
目的：对Hedgehog信号通道相关干细胞的增殖及分化研究近况进行综述。
方法：应用计算机检索CNKI和PubMed数据库中2000-01/2010-12关于Hedgehog信号通路的文章，在标题和摘要中以“hedgehog信号通道，细胞增殖，细胞分化，信号调控”或“Hedgehog signaling pathway，cell proliferation，cell differentiation，signal pathway controlling”为检索词进行检索，选择关于Hedgehog信号通道对各种干细胞及成体器官作用内容的文章，初检到169篇，根据纳入标准选择27篇进行综述。
结果与结论：具有多种分化潜能的干细胞发育成具有特定生物学功能的组织细胞是受到干细胞自身或外在的、近程或远程的信号调控的，其中细胞之间的相互信息传递在细胞发育分化过程中扮演着重要角色。Hedgehog 信号通路起到维持细胞增殖、分化、凋亡之间的平衡，其能够调节相邻细胞之间的分子差异，对细胞分化命运起决定性作用。

关键词: 细胞增殖, 细胞分化, hedgehog信号通道, 信号调控, 干细胞

Abstract:

BACKGROUND: Hedgehog protein is morphogen, and the signal pathway which is related to Hedgehog protein takes part in the embryogenesis and proliferation and differentiation of adult tissues.
OBJECTIVE: To review the proliferation and differentiation of stem cells related to Hedgehog signal pathway.
METHODS: The articles related to Hedgehog signaling pathway in CNKI database and PubMed Database from January 2000 to December 2010 were retrieved with the key words of “Hedgehog signaling pathway, cell proliferation, cell differentiation, signal pathway controlling”. The articles related to the function of Hedgehog signaling pathway to several kinds of stem cells and adult organs were selected. A total of 169 literatures were obtained from computer screen, and 27 documents of them were involved for summarization according to inclusion criteria.
RESULTS AND CONCLUSION: Stem cells with multiple differentiation potential developed into histiocytes with special biological function were regulated by stem cells or external, short-range or long-range signal. Intercellular information transfer plays an important role in the development and differentiation of cells. Hedgehog signal pathway can maintain the balance of cell proliferation, differentiation and apoptosis, and can regulate molecular difference among flanking cells, and play a crucial effect on cell differentiation.

中图分类号: