中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (32): 6048-6051.doi: 10.3969/j.issn.1673-8225.2010.32.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

白血病干细胞表面分子、调控机制及微环境的靶向治疗

周  玫，欧阳晨曦   

  1. 华中科技大学同济医学院附属协和医院血管外科，湖北省武汉市  430022
  • 出版日期:2010-08-06 发布日期:2010-08-06
  • 通讯作者: 欧阳晨曦，副教授，副主任医师，硕士导师，华中科技大学同济医学院附属协和医院血管外科，湖北省武汉市 430022 ouyangchx@yahoo.com
  • 作者简介:周玫★，女，1985年生，湖北省武汉市人，汉族，在读硕士，主要从事白血病干细胞的研究。 zmlucia1985@yahoo.com.cn

Targeted therapy of surface molecules, regulatory mechanisms and microenvironment of leukemia stem cells 

Zhou Mei, Ouyang Chenxi   

  1. Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan  430022, Hubei Province, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Ouyang Chenxi, Associate professor, Associate chief physician, Master’s supervisor, Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China ouyangchx@yahoo. Com
  • About author:Zhou Mei★, Studying for master’s degree, Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China zmlucia1985@yahoo.com.cn

PDF

492

被引次数

4

摘要：

背景：随着白血病干细胞概念的提出以及研究的不断深入，针对白血病干细胞的靶向治疗成为可能，有望发现新的更有效的治疗方法。
目的：综述白血病干细胞的相关研究进展。
方法：应用计算机检索1989-01/2010-01维普中文期刊数据库相关文章，检索词为“白血病干细胞”，并限定文章语言种类为中文。同时计算机检索1995-01/2010-01西文生物医学期刊文献服务系统(FMJS)相关文章，检索词为“leukemia stem cells”，并限定文章语言种类为English。共检索到文献154篇。
结果与结论：随着白血病干细胞概念的提出以及研究的不断深入，针对白血病干细胞的靶向治疗成为可能，通过对白血病干细胞的分离、纯化、鉴定及其特性的研究，试图研发针对白血病干细胞表面分子、调控机制及其微环境的靶向治疗，初步研究证实有一定的可行性，但研究中的混杂因子较多，动物模型难以完全模拟真实的体内环境。

关键词: 白血病干细胞, 靶向治疗, 微环境, 调控, 白血病

Abstract:

BACKGROUND: With the proposition and deep research of leukemia stem cells, it is possible to find out new ways to treat leukemia more effectively, which are targeting leukemia stem cells.
OBJECTIVE: To review the research concerning leukemia stem cells.
METHODS: A computer-based search was undertaken in Vip database for articles published from January 1989 to January 2010 with the key words of “leukemia stem cells” in Chinese. Simultaneously, Foreign Medical Journal Service was searched for the articles about leukemia stem cells published between January 1995 and January 2010, with the key words of “leukemia stem cells” in English. A total of 154 articles were collected.
RESULTS AND CONCLUSION: With the proposal of leukemia stem cells concept and deep research, the targeted therapy for leukemia stem cells became possible. Through the isolation, purification and identification of leukemia stem cells, experts tried to develop new ways to treat leukemia, which are targeting cellular surface molecules, regulatory mechanisms and microenvironment of leukemia stem cells. Primary results proved that these methods are feasible. However, some confounding factors should be excluded. Animal models are difficult to completely simulate in vivo environment.

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