中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5395-5398.doi: 10.3969/j.issn.1673-8225.2010.29.019

• 生物材料基础实验 basic experiments of biomaterials • 上一篇    下一篇

亚微米羟基磷灰石/聚乳酸复合材料的制备及形貌分析

杜江华 1，2，李  丹1，韩风兰1，杨青芳2   

  1. 1北方民族大学材料学院，宁夏回族自治区银川市 750021;2 西北工业大学理学院应用化学系，陕西省西安市 710072
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 通讯作者: 杨青芳，教授，博士生生导师，主要从事医用生物高分子材料的研究及其医用器械的研制，西北工业大学理学院应用化学系，陕西省西安市 710072 nwpudjh@sina.com.cn
  • 作者简介:杜江华☆，男，1979年生，宁夏回族自治区中卫市人，西北工业大学应用化学系在读博士，讲师，主要从事生物医用材料的研究。 nwpudjh@sina.com
  • 基金资助:

    北方民族大学校级课题项目（2007Y042），课题名称：新型亚微米羟基磷灰石/左旋聚乳酸杂化材料的制备及性能研究。

Preparation and surface morphology analysis of submicron nano-hydroxyapatite/poly L-lactic acid composites

Du Jiang-hua 1,2, Li Dan1, Han Feng-lan1, Yang Qing-fang2   

  1. 1 Materials Science & Engineering College, North University for Nationalities, Yinchuan  750021, Ningxia Hui Autonomous Region, China; 2 Department of Applied Chemistry, College of Science, Northwestern Polytechnical University, Xi’an  710072, Shaanxi Province, China
  • Online:2010-07-16 Published:2010-07-16
  • Contact: Yang Qing-fang, Professor, Doctoral supervisor, Department of Applied Chemistry, College of Science, Northwestern Polytechnical University, Xi’an 710072, Shaanxi Province, China nwpudjh@sina.com.cn
  • About author:Du Jiang-hua☆, Studying for doctorate, Lecturer, Materials Science & Engineering College, North University for Nationalities, Yinchuan 750021, Ningxia Hui Autonomous Region, China; Department of Applied Chemistry, College of Science, Northwestern Polytechnical University, Xi’an 710072, Shaanxi Province, China nwpudjh@sina.com
  • Supported by:

     a Grant from North University for Nationalities, No. 2007Y042*

PDF

410

被引次数

13

摘要：

背景：聚乳酸同纳米羟基磷灰石制备骨组织工程支架材料有良好的生物相容性，但是纳米级羟基磷灰石易团聚、很难均匀分散在材料中，使无机粒子和有机高聚物之间的结合状况受影响。
目的：制备亚微米羟基磷灰石/聚乳酸复合材料，探讨聚乳酸溶液浓度、羟基磷灰石在溶液中的分散时间及羟基磷灰石含量对其在聚乳酸基体中分散性的影响，并分析复合材料的表面形貌、断面、复合材料界面状况。
方法：采用溶液共混的方法，借助超声波分散技术，将亚微米羟基磷灰石以不同比例分散于溶剂为氯仿的聚乳酸溶液中，而后在室温下除去混合体系中的氯仿制得不同含量的亚微米羟基磷灰石/聚乳酸复合材料。观察不同溶液浓度对亚微米羟基磷灰石在溶液中的分散性的影响。借助扫描电镜、红外光谱分析亚微米羟基磷灰石/聚乳酸复合材料的断面、界面状况。
结果与结论：在亚微米羟基磷灰石/聚乳酸复合材料质量比为0.15:1，分散时间大于30 min，聚乳酸溶液浓度为0.14 kg/L时，可使得羟基磷灰石在该浓度下有着较好分散性；而当亚微米羟基磷灰石含量超过15%就会在复合材料中产生团聚；红外分析表明，溶液共混制备的复合材料中亚微米羟基磷灰石/聚乳酸复合材料其特征官能团的位置没有发生变化。表明：借助超声波振荡的方法，可实现亚微米亚微米羟基磷灰石与聚乳酸复合材料较好的溶液共混，有望提高复合材料的界面状况。

关键词: 亚微米羟基磷灰石, 聚乳酸, 复合材料, 生物相容性, 组织工程

Abstract:

BACKGROUND: Nano-hydroxyapatite (HA)/poly L-lactic acid (PLLA) composites as scaffold material in bone tissue engineering have good biocompatibility. However, HA is characterized by easy agglomeration and hard equably dispersed in materials, the combination between inorganic particle and organic high polymer is affected. 
OBJECTIVE: To prepare HA/PLLA composite, and study the effect of PLLA solution, the disperser time of HA, the content of HA on dispersion, and analyze the surface appearance, the cross section and the interface of HA/PLLA composites.
METHODS: Sub-micron HA/PLLA composites was prepared by the method of the solution blending, submicron HA powder was dispersed into the chloroform solution of PLLA with the aid of the ultrasonic wave, and then the mixed system was dried under the natural condition to remove the solvent, finally the submicron HA/PLLA compound materials was obtained. The effect of the solution concentration on dispersion HA in solution was discussed. The cross section of composites and interface were analyzed by the Fourier transform infrared spectroscopy and the scanning electron microscopy.
RESULTS AND CONCLUSION: When the mass ratio of sub-micron HA to PLLA was 0.15: 1 and dispersing time HA in PLLA solution exceeded 30 minutes. PLLA solution 0.14 kg/L can make HA good dispersity in PLLA. When sub-micron HA content exceeds 15%, it will produce reunion in composite materials. Infrared analysis shows that characteristic functional groups from HA/PLLA composites have no change. The results suggest that: sub-micron HA can be mixed well with PLLA by ultrasonic oscillation, which would improve the interface of sub-micron HA/PLLA composites.

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