中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (16): 2958-2962.doi: 10.3969/j.issn.1673-8225.2010.16.027

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同材料构建组织工程化血管支架：特点与效应

尹鸣镝1，赵正凯2，张  健3   

  1. 1辽宁省肿瘤医院大肠科，辽宁省沈阳市   110015；2辽宁省金秋医院神经内科，辽宁省沈阳市   110015；3中国医科大学附属第一医院血管甲状腺外科，辽宁省沈阳市  110001
  • 出版日期:2010-04-16 发布日期:2010-04-16
  • 作者简介:尹鸣镝☆，男，1971年生，河北省保定市人，汉族，1995年大连医科大学毕业，博士，副主任医师，主要从事肿瘤及血管外科的研究。 yinjiashaoye@163.com

Construction of tissue-engineered blood vessel stent using different materials: Characteristics and effectiveness

Yin Ming-di1, Zhao Zheng-kai2, Zhang Jian3   

  1. 1 Department of Large Intestine, Liaoning Cancer Hospital ＆Institute, Shenyang  110015, Liaoning Province, China; 2 Department of Neurology, Jinqiu Hospital, Shenyang  110015, Liaoning Province, China; 3 Department of Vascular and Thyreoid Surgery, First Affiliated Hospital of China Medical University, Shenyang  110001, Liaoning Province, China
  • Online:2010-04-16 Published:2010-04-16
  • About author:Yin Ming-di☆, Doctor, Associate chief physician, Department of Large Intestine, Liaoning Cancer Hospital ＆Institute, Shenyang 110015, Liaoning Province, China yinjiashaoye@163.com

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摘要：

目的：评价组织工程血管支架材料的性能和应用前景。

方法：以 “组织工程，组织工程血管，干细胞，细胞因子，支架材料为中文关键词；以:“tissue engineering, tissue engineering blood vessel, intravascular stent” 为英文关键词，采用计算机检索1993-01/2009-10相关文章。纳入与有关生物材料与组织工程血管相关的文章；排除重复研究或Meta分析类文章。以30篇文献为主重点讨论了组织工程血管材料的种类及其性能。

结果：血管脱细胞基质可作为一种较理想的支架材料应用于血管组织工程。基于纤维蛋白制成的支架，不但具有理想的生物相容性、生物降解性和较高的亲和性，而且能促进血管生成、组织修复。明胶无抗原性，生物相容性好，可完全生物降解，可以实现支架自身的“血管化”。天然生物材料和合成高分子材料都存在一定不足，将两者按照一定的方法组合构建成一种复合基质，发挥两者各自的优势构建出性能良好的组织工程化血管。纳米修饰技术有望被应用于下一代组织工程化血管移植。

结论：组织工程血管近年来发展迅速，到目前为止，还没有发现一种很理想的血管支架材料。虽然现在天然生物材料成为研究的热点，但是物理机械性能并不能很好地符合支架要求，这就迫切需要新材料的出现，来更好的满足组织化血管支架的要求，达到修复和重建的目的。

关键词: 血管支架, 组织工程, 复合材料, 纳米生物材料, 修复

Abstract:

OBJECTIVE: To evaluate the characteristics and application prospect of tissue-engineered blood vessel stent materials.
METHODS: Using “tissue engineering, tissue engineering blood vessel, intravascular stent” both in Chinese and English as key words to search documents published between January 1993 and October 2009. Literatures concerning biomaterials and tissue engineered blood vessel were included. Repetitive research or Meta analysis was excluded. After selection, 30 documents were included to discuss the kinds and characteristics of tissue-engineered blood vessel materials.
RESULTS: Cellular tissue matrix is a kind of ideal material for intravascular engineering, which had widely applied in tissue-engineered stent. The fibrin-based stents are characterized by good biocompatibility, biodegradation, compatibility, as well as promote vascularization and tissue repair. Gelatin can implement its own “vascularization” due to less antigenicity and can be fully biodegraded. Accordingly, both the natural biomaterials and synthetic polymeric material have certain limitations, thus, the combination of these two materials would construct a tissue-engineered blood vessel stent that has good characteristics. Nano-modified technology is hopeful to be applied in the future transplantation of tissue-engineered blood vessel stent.
CONCLUSION: The tissue-engineered blood vessel developed rapidly in these years. However, as yet, there is not an ideal intravascular stent material. The natural biomaterials arose more attention, but the mechanical function of which is far from the stent requirement. Thus, to reach the aims of repair and reconstruction, new materials are the urgent need in tissue-engineered intravascular stent.

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