中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (21): 3949-3952.doi: 10.3969/j.issn.1673-8225.2011.21.035

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

输尿管支架生物降解材料丙交酯-乙交酯共聚物在体外的降解及临床应用

玉银华   

  1. 张家口市第二医院，河北省张家口市   075000
  • 收稿日期:2011-01-09 修回日期:2010-03-11 出版日期:2011-05-21 发布日期:2011-05-21
  • 作者简介:玉银华，1965年生，北京市人，回族，2004年河北北方学院毕业，主治医师，主要从事普通外科、泌尿外科研究。 zjkdongjiang@sina.com

In vitro degradation and clinical application of lactide-glycolic acid copolymer as ureteral stent materials

Yu Yin-hua   

  1. Second Hospital of Zhangjiakou City, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-01-09 Revised:2010-03-11 Online:2011-05-21 Published:2011-05-21
  • About author:Yu Yin-hua, Attending physician, Second Hospital of Zhangjiakou City, Zhangjiakou 075000, Hebei Province, China zjkdongjiang@sina.com

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476

被引次数

3

摘要：

背景：目前不同形式的输尿管支架均有其并发症，因此，如何选择适宜的支架来治疗泌尿系统疾病是目前医学界研究的热点。
目的：探讨输尿管支架生物降解材料丙交酯/乙交酯共聚物在体外的降解规律及临床应用前景。
方法：由第一作者检索1991-01/2009-12 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及万方数据库(http://www.wanfangdata.com.cn)有关输尿管支架生物降解材料丙交酯-乙交酯共聚物在体外的降解及临床应用方面的文献，英文检索词为“SR-PLGA；in-vitro degradation；degradalion rate”，中文检索词为“丙交酯-乙交酯共聚物；体外降解；降解速率”。检索文献量总计135篇，排除陈旧及重复性文章，最终纳入17篇文献进一步分析。
结果与结论：高分子降解性输尿管支架材料体内外生物降解性质的研究国外报道较少，国内则未见报道，目前该领域处于基础研究阶段。作为生物降解性高分子材料，降解性质及相容性是此种材料得以应用的首要条件，了解材料的降解及相容性对材料的临床应用具有极其重要的意义。输尿管支架生物降解材料丙交酯-乙交酯共聚物的生物相容性良好，通过调整乙交酯与丙交酯的组分比，可有效调节共聚物的降解速率。

关键词: 输尿管支架, 生物降解材料, 丙交酯-乙交酯共聚物, 体外降解, 降解速率

Abstract:

BACKGROUND: Complications exist after transplantation of different forms of ureteral stents. Therefore, how to choose the appropriate stent to treat urinary tract disease is the medical research focus.
OBJECTIVE: To investigate the in vitro degradation rule and clinical application of lactide-glycolic acid copolymer used as ureteral stent materials.
METHODS: The first author searched PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang databases (http://www.wanfangdata.com.cn) for relevant articles published from 1991-01 to 2009-12 with the keywords of “SR-PLGA; in-vitro degradation; degradalion rate” in English and Chinese. Old and repetitive articles were excluded, and finally 17 of 135 articles were included.
RESULTS AND CONCLUSION: There are few reports about the in vivo biodegradable properties of biodegradable polymer ureteral stent materials. As a biodegradable polymer material, natural degradation and compatibility is the primary condition for clinical application. It is of significance to understand material degradation and compatibility in clinical application. Lactide-glycolic acid copolymer as biodegradable ureteral stent material has a good biocompatibility, and the degradation rate of this copolymer can be effectively regulated by adjusting the glycolide and lactide component ratio.

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