中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (20): 3763-3766.doi: 10.3969/j.issn.1673-8225.2011.20.037

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

骨关节炎：关节软骨退变的相关研究与进展

窦晓丽，段晓琴，夏  玲，袁望舒，曲福玲，罗媛媛，刘忠良   

  1. 吉林大学第二临床医学院康复医学科，吉林省长春市  130041
  • 收稿日期:2011-01-08 修回日期:2011-03-09 出版日期:2011-05-14 发布日期:2011-05-14
  • 作者简介:窦晓丽★，女，1984年生，河南省商丘市人，汉族，吉林大学在读硕士，主要从事骨关节炎康复的研究。 Shanshan10086@126.com

Osteoarthritis: Study and progress in articular cartilage degeneration

Dou Xiao-li, Duan Xiao-qin, Xia Ling, Yuan Wang-shu, Qu Fu-ling, Luo Yuan-yuan, Liu Zhong-liang   

  1. Department of Rehabilitation Medicine, the Second Clinical Hospital of Jilin University, Changchun  130041, Jilin Province, China
  • Received:2011-01-08 Revised:2011-03-09 Online:2011-05-14 Published:2011-05-14
  • About author:Dou Xiao-li★, Studying for master’s degree, Department of Rehabilitation Medicine, the Second Clinical Hospital of Jilin University, Changchun 130041, Jilin Province, China Shanshan10086@ 126.com

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摘要：

背景：骨关节炎关节软骨退变被认为是不可逆的病理改变，但其病因及发病机制不清。
目的：总结并探讨骨关节炎的病因、发病机制及相关的生物标志物的最新基础研究进展。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：2000/2010)和Medline数据库(2000/2010)，检索词分别为“骨关节炎，关节软骨，退行性变，基础研究，生物标志物”和“Osteoarthritis，Articular cartilage，degradation，basic research，Biological markers”，语言分别设定为中文和英文。从引起骨关节炎发病的相关因素的作用及相关的生物标志物的变化2方面进行总结，对病理、生物化学和免疫等相关因素及生物标志物的研究现状进行介绍。
结果与结论：共检索到60篇文章，按纳入和排除标准对文献进行筛选，共纳入20篇文章。结果发现，关节软骨退行性变过程中可出现Ⅱ型原胶原羧基端前肽及Ⅱ型胶原羧基端肽等细胞因子的升高，基质金属蛋白酶、生物自由基、一氧化氮及细胞和体液免疫等参与了骨关节炎退行性变的过程，但其具体发病机制目前仍不明确。

关键词: 骨关节炎, 关节软骨, 退行性变, 基础研究, 生物标志物, 骨组织构建

Abstract:

BACKGROUND: Articular cartilage degeneration in osteoarthritis is considered to a irreversible pathological changes, but the etiological factor and pathogenesis remain unclear. 
OBJECTIVE: To summarize and discuss the etiology, mechanisms and the change of related biomarkers of osteoarthritis.
METHODS: First author searched literatures from CNKI and Medline database from 2000 to 2010 using key words of “osteoarthritis, articular cartilage, degradation, basic research, biological markers” in Chinese or English. The manuscripts were summarized from two aspects: role of relative factors caused osteoarthritis and related biomarkers. The pathology, biochemical, immune factors and research status of biomarkers of osteoarthritis were introduced.
RESULTS AND CONCLUSION: Totally 60 papers were searched and 20 papers were selected. The results showed that, type Ⅱ tropocollagen carboxypropeptide and carboxyl terminus increased in the process of articular cartilage degeneration. Matrix metalloproteinases, biological free radicals, nitric oxide and immune factors involved in osteoarthritis degeneration process, but the specific pathogenesis still needs to be explored.

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