中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (29): 5453-5458.doi: 10.3969/j.issn.1673-8225.2011.29.033

• 生物材料综述 biomaterial review • 上一篇    下一篇

高分子材料的表面菌膜

李红梅1，季君晖2   

  1. 1解放军第309医院呼吸科，北京市  100091
    2中国科学院理化技术研究所工程塑料国家工程研究中心，北京市  100190
  • 收稿日期:2011-01-09 修回日期:2011-02-11 出版日期:2011-07-16 发布日期:2011-07-16
  • 通讯作者: 季君晖，博士，研究员，博士生导师，中国科学院理化技术研究所工程塑料国家工程研究中心，北京市 100190
  • 作者简介:李红梅☆，女，1969年生，河北省沧州市人，汉族，2001年解放军军医进修学院毕业，博士，副主任医师，主要从事呼吸病学和感染方面相关临床和基础研究。 lihongmei309@163.com
  • 基金资助:

    浙江省重点科技攻关项目“抗感染高分子材料”(2005C21064)，中科院知识创新工程科技助残专项“抗感染导尿管研制”(KGCX2-YW-608)资助。

Biofilm on the surface of polymers

Li Hong-mei1, Ji Jun-hui2   

  1. 1Department of Respiratory Medicine, the 309 Hospital of Chinese PLA, Beijing  100091, China
    2National Engineering Research Center of Plastics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing  100190, China
  • Received:2011-01-09 Revised:2011-02-11 Online:2011-07-16 Published:2011-07-16
  • Contact: Ji Jun-hui, Doctor, Investigator, Doctoral supervisor, National Engineering Research Center of Plastics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  • About author:Li Hong-mei☆, Doctor, Associate chief Physician, Department of Respiratory Medicine, the 309 Hospital of Chinese PLA, Beijing 100091, China lihongmei309@163.com
  • Supported by:

    the Key Science and Technology Program of Zhejiang Province, No. 2005C21064*; the Science and Technology Program for Disability of Knowledge Innovation Project, Chinese Academy of Sciences, No. KGCX2-YW-608*

PDF

423

被引次数

3

摘要：

背景：医疗器械尤其是高分子介入性导管引起的导管相关型感染是院内感染的主要途径之一，而导致人体感染的真正原因是器械或导管表面形成了菌膜。
目的：对菌膜的形成机制，影响菌膜形成和发展的因素以及当前抑制菌膜形成的常用方法进行综述。
方法：以“菌膜，生物膜，生物被膜”，“高分子，塑料，橡胶”和“biofilm，polymer，plastics，rubber”为检索词在medline、life sciences、Toxline plus、Derwent drug file、CBMDisc、CMCC等数据库和www.ncbi.nlm.nih.gov、www.uspto.gov、www.patent.com.cn等网站进行检索，得到相关国内外文献214篇。排除陈旧和内容类似文献，选择43篇文献进行综述。
结果与结论：目前对菌膜在高分子器械表面形成过程和形成机制已经基本阐述清晰，但迄今为止，菌膜的研究多集中从微生物学、医学、基因角度进行，对菌膜的防治也是直接从利用抗生素的抑制方面考虑，文章着重从材料角度探讨抑制菌膜的可能途径及其在临床应用的可能性。

关键词: 菌膜, 院内感染, 高分子材料, 形成, 抑制

Abstract:

BACKGROUND: Widely application of medical devices, especially application of polymeric catheters and tubes is one of the important approaches which lead to catheter-related infection. Biofilm which formed on the surface of the polymeric medical devices in the application process is just the reason for this nosocomial infection.
OBJECTIVE: To review the formation procedures of biofilm and the factors influencing the formation and progression of biofilm, as well as common methods to inhibit biofilm formation.
METHODS: With key words “mycoderm, biomembrane, biofilm”; “polymer, plastics, rubber” in Chinese and English, a computer-based online search of medline, life sciences, Toxline plus, Derwent drug file, CBMDisc, and CMCC, as well as www.ncbi.nlm.nih.gov, www.uspto.gov, www.patent.com.cn, was performed. A total of 214 articles were collected, and 43 were included after eliminating repetitive and similar articles.
RERULTS AND CONCLUSION: Formation procedure and mechanism of biofilm on the surface of polymeric devices have been expounded clearly, but researches on biofilm mainly focus on microbiology, medicine or gene, and antibiotics for the prevention and treatment of biofilm. This paper reviewed the effects of matrix material on the inhibiting of formation biofilm and possibility to use in clinic.

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