中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (21): 3969-3971.doi: 10.3969/j.issn.1673-8225.2011.21.040

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

神经组织工程支架或异种神经移植在面神经缺损中的应用

宁丽娜，熊  杰   

  1. 武警医学院附属医院中医康复科，天津市  300162
  • 收稿日期:2011-02-02 修回日期:2011-04-20 出版日期:2011-05-21 发布日期:2011-05-21
  • 通讯作者: 熊杰，博士，教授，主任医师，武警医学院附属医院中医康复科，天津市 300162 drxiongjie@yahoo.com.cn
  • 作者简介:宁丽娜★，女，1981年生，河北省石家庄市人，汉族，2008年天津中医药大学毕业，硕士，医师，主要从事脑血管等神经系统疾病的康复治疗。 biyi4329689@yahoo.com.cn

Nerve tissue engineering scaffolds or heterologous nerve grafts in facial nerve defects

Ning Li-na, Xiong Ji   

  1. Department of Rehabilitation, the Affiliated Hospital of Medical College of CAPF, Tianjin  300162, China
  • Received:2011-02-02 Revised:2011-04-20 Online:2011-05-21 Published:2011-05-21
  • Contact: Xiong Jie, Doctor, Professor, Chief physician, Department of Rehabilitation, the Affiliated Hospital of Medical College of CAPF, Tianjin 300162, China drxiongjie@yahoo.com.cn
  • About author:Ning Li-na★, Master, Physician, Department of Rehabilitation, the Affiliated Hospital of Medical College of CAPF, Tianjin 300162, China biyi4329689@yahoo.com.cn

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288

被引次数

1

摘要：

背景：了解面神经损伤的修复方法，以及各种组织支架的特性与优势，对于修复方法与材料的合理选择是十分必要的。
目的：总结神经组织工程支架或异种神经移植在面神经缺损中的应用进展。
方法：应用计算机检索PubMed数据库及CNKI数据库，在标题和摘要中以“组织工程支架，神经移植，面神经，修复”或“tissue engineering scaffolds，nerve transplantation，facial，repair”为检索词进行检索。根据纳入标准选择21篇文献进行综述。
结果与结论：面神经缺损后立即直接缝合神经的断端是最好的修复方法。自体神经移植受神经移植体来源之限，常造成供区失神经支配；以及产生束外有髓和无髓轴突无规则生长会导致神经纤维错向再生，造成严重的联带运动的不足。异体或异种神经移植法虽然取得了一定的效果，但仍处于动物实验的研究阶段，尚难以应用于临床。

关键词: 神经组织工程支架, 神经移植, 面神经, 修复, 综述文献

Abstract:

BACKGROUND: It is necessary for proper selection of repair methods and scaffold materials to understand repair methods of facial nerve injury and features and benefits of various scaffolds.
OBJECTIVE: To summarize the progress in nerve tissue engineering scaffolds or heterologous nerve grafts for repair of facial nerve defects.
METHODS: A computer search of PubMed and CNKI databases were performed using keyword of “tissue engineering scaffold, nerve transplantation, facial, repair” in Chinese and English. Totally 21 articles were reviewed.
RESULTS AND CONCLUSION: It is the best method to directly suture nerve stump immediately after facial nerve defects. Autologous nerve grafting is limited by implant sources, which often result in denervation of the donor site. Irregular growth of extrapyramidal myelinated and non-myelinated axons can lead to the fault regeneration of nerve fibers, causing serious shortcomings associated with the movement. Allogeneic or xenogeneic neural transplantation has yielded some results, but it is still used in the research phase of animal testing, which is difficult for clinical application.

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