中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (25): 4673-4676.doi: 10.3969/j.issn.1673-8225.2010.25.028

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

羟考酮控释片联合双膦酸盐治疗骨转移癌69例

李宇清1，何雁冰2，杜志强3   

  1. 广州医学院第二附属医院，1肿瘤科，2麻醉科，广东省广州市   510260；3广州医学院荔湾医院肿瘤科，广东省广州市   510170
  • 出版日期:2010-06-18 发布日期:2010-06-18
  • 作者简介:李宇清★，女，1969年生，广东省南海市人，汉族，1993年中山医科大学毕业，硕士，副主任医师，主要从事肿瘤内科研究。 yuqinglee@21cn.com

Controlled-release oxycodone hydrochloride tablets in combination with bisphosphonates for skeletal metastases-caused pain in 69 cases

Li Yu-Qing1, He Yan-bing2, Du Zhi-Qiang3   

  1. 1 Department of Oncology, 2 Department of Anesthesiology, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou  510260, Guangdong Province, China; 3 Department of Oncology, Liwan Hospital Affiliated to Guangzhou Medical University, Guangzhou  510170, Guangdong Province, China
  • Online:2010-06-18 Published:2010-06-18
  • About author:Li Yu-qing★, Master, Associate chief physician, Department of Oncology, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China yuqinglee@21cn.com

PDF

474

被引次数

17

摘要：

背景：盐酸羟考酮控释片属于第3阶梯用药，是治疗中重度癌痛的主要方法之一。
目的：观察盐酸羟考酮控释片联合双膦酸盐治疗骨转移癌性疼痛的疗效及不良反应。
方法：对69例骨转移癌患者口服盐酸羟考酮控释片治疗，在用药过程中根据疼痛缓解程度调整剂量；同时静脉滴注唑来膦酸4 mg每4周1次，连续2次后评价疗效和不良反应。
结果与结论：发现骨转移癌患者的骨痛完全缓解25例(36%)，部分缓解37例(54%)，轻度缓解7例(10%)，总有效率为90% (62/69)；不良反应有便秘、恶心呕吐、腹胀、厌食、嗜睡、头晕、发热、肌肉痛等。结果表明，盐酸羟考酮控释片联合双膦酸盐治疗骨转移癌性疼痛疗效确切，有效率高，不良反应轻，患者可以耐受。

关键词: 盐酸羟考酮控释片, 双膦酸盐, 骨转移癌, 疼痛, 药物控释系统及其载体材料

Abstract:

BACKGROUND: Oxycodone hydrochloride is the medicine at the third step and is one of the most frequent medicines in treating severe cancer pain.
OBJECTIVE: To evaluate the efficacy and side effects of controlled-release oxycodone hydrochloride tablets and bisphosphonates on the treatment of skeletal metastases.
METHODS: A total of 69 patients suffering from skeletal metastases were treated with oral controlled-release oxycodone hydrochloride tablets, and the dosages were titrated according to the severity of pain. In addition, intravenous infusion of Zoledronic Acid was performed, 4 mg every 4 weeks. The efficacy and side effects of the treatment were evaluated after 2 cycles.
RESULTS AND CONCLUSION: Of the 69 patients, 25 cases (36.2%) achieved complete remission, 37 cases (53.6%) achieved partial remission, and 7 cases (10.1%) achieved minor remission．Pain relief was 89.9% (62/69). The side effects included constipation, nausea and vomiting, abdominal distention, anorexia, lethargy, dizziness, fever and muscle pain. Results show that the treatment using controlled-release oxycodone hydrochloride tablets and bisphosphonates is safe and effective for skeletal metastases. Its side effects are minor and tolerable．

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