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    23 April 2014, Volume 18 Issue 17 Previous Issue    Next Issue
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    Icariin intervenes wear particles-induced osteolysis
    Wang Jun, Zhu Xu-ri, Zhang Chao, Shen Ji-rong, Du Bin
    2014, 18 (17):  2625-2631.  doi: 10.3969/j.issn.2095-4344.2014.17.001
    Abstract ( 380 )   PDF (2164KB) ( 331 )   Save

    BACKGROUND: Osteolysis surrounding artificial joints is the main reason for the failure of joint loosening. Scholars all over the world are seeking an effective drug to inhibit osteolysis so as to reduce the occurrence of prosthetic loosening.
    OBJECTIVE: To observe the effects of different doses of icariin on osteolysis induced by wear particles.
    METHODS: The wear debris (Ti alloy and bone cement) was put into mouse cranium to create mouse models of calvarial osteolysis. Physiological saline was dropped in the cranium in the blank group. Different concentrations of icariin (30, 60 and 120 mg/kg) were given in the drug intervention group, by intragastric administration, once a day. At 2 weeks after model induction, mice were sacrificed. The structure of mouse cranium was observed under a microscope. Hematoxylin-eosin staining and immunohistochemical staining were performed. The number of osteoclasts and the changes in the calvarial osteolysis area of mice after intervention were calculated.
    RESULTS AND CONCLUSION: Compared with the blank group, the number of absorption pits of bone slices that were stimulated by wear debris (Ti alloy and bone cement) and the number of osteoclasts were significantly increased, and absorption pits area was also bigger (P < 0.05). After intervention with icariin, osteolysis area and the number of osteoclasts became less (P < 0.05), especially in the 120 mg/kg gavage group, followed by 60 mg/kg and 30 mg/kg. Results suggested that Ti particles and bone cement particles can promote osteoclast proliferation and osteolysis. Icariin can suppress the formation of osteoclasts induced by particles, resulting in inhibiting osteolysis.  


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Anatomical characteristics of axial lines and angles of rotational alignment of the femur during prosthetic installation
    Zhao Zhi-jiang, Xu Hong-sheng, Meng Wei-ming, Zhang Xiao-wei, Zhang Lei
    2014, 18 (17):  2632-2636.  doi: 10.3969/j.issn.2095-4344.2014.17.002
    Abstract ( 418 )   PDF (755KB) ( 533 )   Save

    BACKGROUND: Good rotational location for femoral prosthesis is a key in total knee replacement, which is strongly associated with joint function after replacement. Each anatomical parameter of femoral condyle is also very important. To familiar with each data can do reasonably ostectomy and select axis, can avoid poor location of prosthesis-induced joint dysfunction after total knee replacement.
    OBJECTIVE: To observe the anatomical structure of femoral condyle specimens, and measure the angle between anatomical parameter and the axis.
    METHODS: A total of 40 femoral bone specimens were fixed on the frame. Morphological changes in the medial epicondyle and the lateral epicondyle were observed. Femoral condyle parameters, including length and width, were measured. Kirschner wire was used between the medial epicondyle and the lateral epicondyle using a targeting device. After ostectomy, four axial lines were measured with a conimeter, including surgical epicondylar axis, clinical epicondylar axis, posterior condylar line and anterior-posterior axis.
    RESULTS AND CONCLUSION: The depression of medial epicondyle appeared relatively low, accounting for 25% of the total number of all specimens; the height of the femoral condyle did not have significant difference compared with westerners, but width was smaller compared with westerners. Thus, the surgeons should be fully aware of the width of femoral condyle in operative procedures. The appearance of depression of medial epicondyle was not frequent, so posterior condylar angle of epicondylar axis was only fit for some persons. However, anterior-posterior axis was easily to be located. The angle between two axes and posterior condylar line was stable, and variability was small. Thus, the anterior-posterior axis can be used as a reliable label for rotational position of femoral prosthesis.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Total hip replacement or hemiarthroplasty for elder femur neck fracture patients
    Zhou Yuan, Wang Jing-cheng, Hu Han-sheng
    2014, 18 (17):  2637-2642.  doi: 10.3969/j.issn.2095-4344.2014.17.003
    Abstract ( 1479 )   PDF (718KB) ( 764 )   Save

    BACKGROUND: Recently, the number of elder patients with femoral neck fracture increased. It is controversial if patients aged over 75 years should receive total hip replacement or hemiarthroplasty. To select a reasonable surgical manner is of great significance for increasing surgical safety, improving hip joint function, elevating quality of life, decreasing postoperative complications, and reducing revision rate.
    OBJECTIVE: To retrospectively analyze data of patients aged over 75 years after hip replacement, to compare the advantages and disadvantages, and to find a precise indication.
    METHODS: Case data of 171 patients undergoing total hip replacement (observation group) (n=51) or hemiarthroplasty (control group) (n=120) were included. Their differences were compared using basic diseases, operation time, bleeding amount, postoperative complications, postoperative hospitalization day, Harris score at 1 week and 3 months after operation.
    RESULTS AND CONCLUSION: Patients in both groups were followed up for 3 to 39 months (averagely 23 months). No significant difference in basic diseases, average age, postoperative complications, postoperative  hospitalization day, and Harris score at 1 week was detected between the two groups (P > 0.05). Harris score and excellent and good rate at 3 months were better in the total hip replacement group than that in the hemiarthroplasty group (P < 0.05). Results indicated that strict choice of indication achieved good short-period efficiency in two groups. Thus, hip function of elder patients was early recovered. Quality of life was obviously elevated. The recovery of hip function was relatively better at 3 months in observation group. The incidence of postoperative complications did not increase obviously. These results suggested that besides sufficient preparation, total hip replacement should be the first choice for elder patients.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Application of constrained polyethylene insert to primary total knee arthroplasty in older patients
    Song Yu-cheng, Fang Rui, Meng Qing-cai, Liu Peng-cheng, Liao Jun, Shi Liang
    2014, 18 (17):  2643-2648.  doi: 10.3969/j.issn.2095-4344.2014.17.004
    Abstract ( 504 )   PDF (704KB) ( 410 )   Save

    BACKGROUND: Valgus-varus constrained polyethylene insert is selected in strict accordance with the principle of “to obtain reliable stability using minimum restriction”. The stability of the prosthesis is elevated, but the restriction is not increased.
    OBJECTIVE: To retrospectively analyze the application experience of constrained polyethylene insert in valgus and varus instability of primary total knee arthroplasty for older patients and to summarize the indications and clinical effects of this kind of implements.
    METHODS: From March 2010 to March 2012, a total of 70 patients combined valgus and varus malfomation who accepted primary total knee arthroplasty were enrolled in this study, including 56 varus patients (averagely 15°-30°) and 14 valgus patients (averagely 10°-20°). Constrained polyethylene insert was performed in 23 patients (25 knees) who still had remaining unilateral valgus or varus < 6 mm (18 patients were varus instability and 7 patients were valgus instability) when finished operation of standard osteotomy and soft tissue balancing. The bone cement knee prostheses in 23 cases were purchased from Smith & Nephew. The stem implant was not used in all cases. Cement or autografts were used in 11 valgus knees to fill the bone defects.
    RESULTS AND CONCLUSION: Patients were followed up for 2 years on average (18-42 mouths). The knee pain symptoms of all cases disappeared. The joint stability was obviously improved. The lower limb power lines were correct. The Knee Society Score scores were improved from an average of 39.4 points preoperation to an average of 88.5 points postoperation. All cases did not need the protection of knee braces. The maximum degree  of flexion was 110°(96°-130°). The satisfaction degree of 36-Item Short Form Health Survey was 98%. No dislocation or infection happened. Results indicated that constrained polyethylene insert could be applied in the cases of less than 6 mm valgus and varus instability when finished operation of standard osteotomy and soft tissue balancing in total knee arthroplasty for older patients. This kind of implements can preserve bone mass, simplify operational process and have good clinical outcome in a short period.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Drainage effects in total knee arthroplasty
    Dong Pan-feng, Chen Yue-ping, Kang Jie, Zhang Xiao-yun, Rao Yi
    2014, 18 (17):  2649-2654.  doi: 10.3969/j.issn.2095-4344.2014.17.005
    Abstract ( 434 )   PDF (729KB) ( 440 )   Save

    BACKGROUND: Drainage has been applied as a routine to hip and knee replacement surgery. However, as a potential channel, drainage could become a portal for bacteria and other pathogens to invade the joint cavity.
    OBJECTIVE: To evaluate the clinical significance and safety of drainage in total knee arthroplasty.
    METHODS: The 80 patients were prospectively randomized into two groups: Group 1 included 38 patients with wound drainage; Group 2 included 42 patients without any drainage. According to a formula calculation, blood loss, the number of subjects requiring blood transfusion, volume of blood transfusion, complications and the recovery of function after total knee arthroplasty were statistically analyzed.
    RESULTS AND CONCLUSION: The subjects were followed up for 2 years after discharge. Two patients lost to follow up in the non-drainage group. 78 patients were involved in the result analysis. The total blood loss, the number of subjects requiring blood transfusion and volume of blood transfusion were more in the drainage group than those in the non-drainage group after surgery. At 3 days after arthroplasty, active range of motion was larger in the drainage group than that in the non-drainage group. No significant differences in hemoglobin levels and Keen Society Score scores were detected after arthroplasty between the two groups. Results suggested that draining will increase the blood loss and blood transfusion, but it may contribute to the early recovery of knee function. No significant differences in long-period Keen Society Score scores and postoperative complications were detectable between the two groups.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Individual designed titanium mesh used in bone graft fusion and internal fixation to restore cervical curvature
    Wen Rui, Ye Fei, Pu Hai-bo, Wei Shu-yi
    2014, 18 (17):  2655-2658.  doi: 10.3969/j.issn.2095-4344.2014.17.006
    Abstract ( 268 )   PDF (542KB) ( 318 )   Save

    BACKGROUND: Titanium mesh is a new type of bone graft supports used for the treatment of spine, especially the cervical spine disorders at home and abroad in recent years. But, at present, how to improve the cervical lordosis curvature during anterior surgery is the difficulty for the treatment of cervical spondylotic myelopathy. 
    OBJECTIVE: To observe the effect of straight titanium mesh and individual designed titanium mesh used in the bone graft fusion and internal fixation on the recovery of cervical curvature and Japanese Orthopaedic Association score during anterior cervical subtotal vertebrectomy in the patients with cervical spondylotic myelopathy.  
    METHODS: Forty-three patients with cervical spondylotic myelopathy treated with surgical indications of subtotal vertebrectomy and decompression internal fixation were included, and the patients were divided into two groups according to different internal fixation methods. There were 15 cases in the individual designed titanium mesh group and 28 cases in the straight titanium mesh group. The preoperative anteroposterior X-ray films of the cervical spine of all the patients were as the blank control group. The clinical data of the patients in two groups were retrospectively analyzed, and the postoperative Japanese Orthopaedic Association score, cervical curvature, intervertebral angles and intervertebral height were compared.
    RESULTS AND CONCLUSION: The cervical lordosis angle and the intervertebral angle of surgery segment in the individual designed titanium mesh group were improved when compared with those in the straight titanium mesh group and the blank control group (P < 0.01), and the straight titanium mesh group was better than the blank control group (P < 0.05). The intervertebral height of surgery segment in the individual designed titanium mesh group and the straight titanium mesh group was increased for 3.69 mm and 3.22 mm respectively when compared with that in the blank control group, and there was significant difference between individual designed titanium mesh group and the straight titanium mesh group (P > 0.05). There was no significant difference in Japanese Orthopaedic Association score between individual designed titanium mesh group and the straight titanium mesh group (P > 0.05). During subtotal vertebrectomy for the treatment of cervical spondylotic myelopathy, cutting titanium mesh into trapezoidal shape to simulate the normal disc shape of former high to low can effectively restore the physiological curvature of cervical spine and the intervertebral height of surgery segment.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Lumbar biomechanical characteristics after microsurgical lumbar discectomy with different proportions of nucleus pulposus: finite element analysis
    Chen Hua-xing, Yang Sheng, Lu Jian-min, Yu Yan-nan, Yuan Chi, Ren Fu-quan, Liu Ji-feng, Zhao Guo-quan, Li Shu-qiang
    2014, 18 (17):  2659-2666.  doi: 10.3969/j.issn.2095-4344.2014.17.007
    Abstract ( 411 )   PDF (1145KB) ( 377 )   Save

    BACKGROUND: Most finite element models of microsurgical lumbar discectomy are built on the basis of normal vertebral bodies in China to remove the complete nucleus pulposus tissue. However, it did not consider the only part of nucleus pulposus removal in the process of actual operation and the impact of vertebral lamina fenestration on spinal mechanics at the same time.
    OBJECTIVE: To establish precisely three-dimensional finite element model (L4/5) to compare biomechanical characteristics caused by the different proportions of discectomy under a microscope. 
    METHODS: One patient with lumbar intervertebral disc herniation was selected. Preoperative CT data were used to construct finite element models, and its effectiveness was validated. Postoperative CT data were collected. Degeneration model, vertebral lamina fenestration model, microsurgical lumbar discectomy model (removal of a third of nucleus pulposus) and all nucleus pulposus resection model were constructed. Under specific loading conditions, biomechanical characteristics were compared in the flexion-extension, lateral bending, and axial rotation conditions.
    RESULTS AND CONCLUSION: Finite element models of lumbar vertebrae were accurately established after discectomy at various proportions under the microscope. Mechanical property analysis demonstrated that after microsurgical lumbar discectomy and removing different proportions of nucleus pulposus, under flexion-extension condition, the end max-stress distributed in the isthmus and the superior articular facet, besides the stability of the lumbar spine, was reduced. This change on the opposite direction of vertebral lamina fenestration was most obvious when lateral-bending and backward extension condition. The proportion of nucleus pulposus removal was associated with its effects.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Finite element calculation of head and neck lag screws in different placement positions for intertrochanteric fracture
    Wang Dong-dong, Gao Feng, Cheng Jie-ping, Miao Wei-wei, Xu Chun-hua, Zhu Wei-min
    2014, 18 (17):  2667-2672.  doi: 10.3969/j.issn.2095-4344.2014.17.008
    Abstract ( 285 )   PDF (2130KB) ( 384 )   Save

    BACKGROUND: Our team summarized and found that in addition to a small part due to the intertrochanteric comminuted and individual existence of the reset problem in the postoperative cases of coxa vara, radiograph of the vast majority of patients with complications after review revealed: two head and neck lag screws were positioned in the upper and middle femoral neck.
    OBJECTIVE: To verify the biomechanical properties of lag screws in different points of the neck of proximal femur using finite element calculation so as to guide the implantation of proximal femoral intramedullary nail and to reduce the occurrence of complications.
    METHODS: Three dimensional models of fracture undergoing intramedullary nail implantation in the proximal femur were established by using Boolean operation in MIMICS. This experiment contained two groups: in the lower and middle group, the lag screw was placed in the 1/3 lower and middle neck of femur; in the upper and middle group, the lag screw was placed in the 1/3 upper and middle neck of femur. The stress distribution of femur and proximal femoral intramedullary nail was calculated using finite element software when lag screw was implanted at different directions.
    RESULTS AND CONCLUSION: Results of the stress distribution of the fracture broken ends showed that the stress of the small trochanter was less in the lower and middle group than that in the upper and middle group. Moreover, mean value of maximal stress of intramedullary nail in the proximal femur was larger in the lower and middle group than that in the upper and middle group. Results of the opening angle of the fracture surface demonstrated that the opening angle of the fracture surface after loading was smaller in the lower and middle group than that in the upper and middle group. Analysis results of the relationship between load and displacement displayed that the total displacement of the top of the femur after loading was smaller in the lower and middle group than that in the upper and middle group. These results confirmed that two head and neck lag screws in the 1/3 lower and middle femoral neck showed perfect biomechanical property, stable structure, and reasonable stress, which has important reference values in the clinic.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Clinical value of computer-aided technology in diagnosis and treatment of pelvic fracture
    Meng Bo, Sun Hai-yu, Li Ming, Li Shu-wei, Wang Da-wei, Ning Si-min
    2014, 18 (17):  2673-2678.  doi: 10.3969/j.issn.2095-4344.2014.17.009
    Abstract ( 433 )   PDF (955KB) ( 399 )   Save

    BACKGROUND: The rapid development of computer technology has realized the leap from two-dimensional image to three-dimensional image. With the perfect combination of the rapid prototyping technique, the clinician can accurately judge the fracture location and draw up a plan of operation. Preoperative fracture reduction and simulation obviously improve the safety and quality of the operation.
    OBJECTIVE: To evaluate the clinical value of computer-aided technology in diagnosis and treatment of pelvic fracture.
    METHODS: We collected 20 patients with pelvic fractures, who were randomly divided into the computer-aided group and the traditional surgery group. Traditional surgical method only needed X-ray and two-dimensional CT scanning of pelvis. Computer-aided group needed to extract original CT data, used MIMICS software for three-dimensional reconstruction. The models of pelvic and steel plate were made using rapid prototyping technique according to the proportion of 1:1. Performers and participants completed surgical simulation training before the operation. Time used in surgery and volume of blood loss during operation were recorded, and compared with the traditional surgery.
    RESULTS AND CONCLUSION: What seen in the operation was very similar to what seen from the preoperative model of pelvic fracture. The preoperative practice made participants more tacit understanding, resulting in operating quicker and more accurate. All patients of computer-aided group got good fracture reduction, intraoperative steel plate bending more fitting for bone, the length of the steel nail was more appropriate, the location was better. Compared with traditional surgery, computer-assisted surgery had less blood loss, shorter operation time and more statistically significant difference (P < 0.05). Computer-aided clinical surgery has characteristics of small trauma, more accurate, more safety for patients and medical staffs, and has broad  application prospects in orthopedics and other departments.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Proximal femoral nail antirotation for intertrochanteric fractures in elderly patients
    Wang Guo-dong, Yuan Tong-zhou, Xu Nuo, Zhu Qi-fei, Fan Lei, Wei Xin-cheng, Yang Ling-yun, Zhang Jin-zhang, Huang Ye
    2014, 18 (17):  2679-2684.  doi: 10.3969/j.issn.2095-4344.2014.17.010
    Abstract ( 393 )   PDF (775KB) ( 366 )   Save

    BACKGROUND: Proximal femoral nail antirotation has a precise positioning device. Small incision closed reduction was used during implantation after fracture. This method induces few traumas and less damage to blood transportation at the fracture end, and is accorded with “BO” theory and the principle of small invasive operation for treatment of fracture.
    OBJECTIVE: To retrospectively analyze the clinical therapeutic effects of proximal femoral nail antirotation for intertrochanteric fractures in senile patients.
    METHODS: A total of 48 patients with intertrochanteric fractures were enrolled, including 30 males and 18 females, aged 70-86 years old, averagely 77.3 years. According to AO classification, there were 12 cases of 31-A1, 23 cases of 31-A2 and 13 cases of 31-A3. Closed reduction and proximal femoral nail antirotation were utilized. Fracture healing and the position of the device were understood by regular follow-up. Functional recovery of the hip joint was evaluated using Harris score after surgery.
    RESULTS AND CONCLUSION: Bone union was observed in 48 cases, averagely 4.5 months. Satisfactory reduction was obtained in all intertrochanteric fractures. The position of the nail was satisfactory. No complications appeared such as loosing, prolapse, ineffective fixation, avascular necrosis of the femoral head and coxa vara malformation. During final follow-up, Harris score revealed excellent in 31 cases, 14 in good and 3 in average, with an excellent and good rate of 93.7%. Results indicated that proximal femoral nail antirotation for intertrochanteric fractures in elderly patients was in accordance with the requirement of biomechanics, and was safe and effective.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Accurate positioning way to modify minimally invasive incision in the treatment of intertrochanteric fractures with proximal femoral nail antirotation
    Liang Chang-xiang, Zheng Xiao-qing, Chang Yun-bing, Gu Hong-lin, Huang Shuai-hao
    2014, 18 (17):  2685-2690.  doi: 10.3969/j.issn.2095-4344.2014.17.011
    Abstract ( 442 )   PDF (704KB) ( 395 )   Save

    BACKGROUND: Closed reduction using proximal femoral nail antirotation gradually becomes the golden standard in the treatment of intertrochanteric fractures.
    OBJECTIVE: To evaluate the advantages of proximal femoral nail antirotation in the treatment of intertrochanteric fractures by a new way that accurate positioning is used to modify the skin incision.
    METHODS: Ninety-nine patients with intertrochanteric fractures undergoing proximal femoral nail antirotation were included in the study, including 41 cases in the modified incision group and 58 cases in the standard operation group. Length of skin incision, mean bleeding volume, mean operation time, mean hospitalization time and the Harris scores were compared between two groups postoperatively.
    RESULTS AND CONCLUSION: Compared with the standard incision group, the mean bleeding volume and length of skin incision were decreased by 50.9% and 44% respectively in the modified incision group, as well as the mean operation time was also shorter in the modified incision group (P < 0.05). However, there was no difference in mean hospitalization time and Harris scores at the end of follow-up. The modified incision is more suitable for proximal femoral nail antirotation treatment of intertrochanteric fractures, with smaller incision, less trauma, shorter operation time and less blood loss.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Clavicular hook plates for acute acromioclavicular dislocations: simultaneous repair of coracoclavicular ligament?
    Gui Ke-ke, Zhang Xin-chao, Yin Wang-ping, Yu Yong-lin
    2014, 18 (17):  2691-2696.  doi: 10.3969/j.issn.2095-4344.2014.17.012
    Abstract ( 337 )   PDF (715KB) ( 579 )   Save

    BACKGROUND: Clavicular hook plates have been used widely to treat acromioclavicular dislocations in recent years. However, it remains controversial whether coracoclavicular ligament should be repaired during the surgery.
    OBJECTIVE: To study the clinical effect and MRI manifestations after treatment of type III and V acute acromioclavicular Rockwood dislocation with clavicular hook plate, and to discuss the necessity of repairing coracoclavicular ligament during the surgery.   
    METHODS: A total of 44 patients with type III and V acute acromioclavicular Rockwood dislocations were treated with clavicular hook plates without repair of coracoclavicular ligaments, and underwent plate removal operations later. At 24 months after the second surgery, X-rays were taken to measure the width of coracoclavicular joints in both normal and affected limbs, Constant-Murley scores were calculated in both sides, and MR images were used to observe the healing of coracoclavicular ligaments. 
    RESULTS AND CONCLUSION: 39 patients (89%) were followed up for 36.9±3.1 months (range, 30 to 45 months). The mean duration for retaining clavicular hook plates was 12.9±3.1 months (range, 6 to 21 months). The mean width of coracoclavicular joints was 6.04±1.21 mm (range, 4.3 to 8.8 mm) in normal limb, while 5.09±1.18 mm (range, 3.4 to 7.8 mm) in affected side without significant difference (P > 0.05). The mean Constant-Murley score was 98.9±1.2 (range, 96 to 100) in normal limb, while 96.7±3.4 (range, 90 to 100) in affected side without significant difference (P > 0.05). MRI showed healing of the coracoclavicular ligaments and the presence of continuous scar tissue in 38 patients, excluding one patient with recurrence of acromioclavicular joint dislocation. The clinical effects after treatment of type III and V acute acromioclavicular Rockwood dislocation with clavicular hook plate are satisfactory, and it is unnecessary to repair coracoclavicular ligament during the surgery. MR images reveal scar healing of the coracoclavicular ligaments without operative repair.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Cannulated lag screws for Hoffa fracture: evaluation for functional recovery
    Chen Tie-zhu, Wang Yi-sheng
    2014, 18 (17):  2697-2702.  doi: 10.3969/j.issn.2095-4344.2014.17.013
    Abstract ( 479 )   PDF (771KB) ( 655 )   Save

    BACKGROUND: Hoffa fracture belongs to intraarticular fracture, and is rare in the clinic. It is difficult to be diagnosed in clinic and radiographs. Missed diagnosis easily occurs, so it is hard to be cured. Improper therapy would induce disunion of fracture or knee dysfunction.
    OBJECTIVE: To observe the clinical efficacy of Hoffa fracture treated with cannulated lag screws.
    METHODS: From May 2007 to April 2012, seven patients with Hoffa fracture were treated with cannulated lag screws, including 5 males and 2 females, aged from 23 to 57 years old, averagely 37 years old. They accepted the X-ray, CT and MRI examinations of anteroposterior and lateral knee joints. After surgery, facture healing, the incidence of complications and recovery of limb function were observed during follow-up.
    RESULTS AND CONCLUSION: All patients were followed up for 18-36 months, averagely 24 months. Fractures were healed. Complications did not occur such as loosing fixation and fracture re-displacement. The range of motion of knee joint was greater than 110°. According to the knee Letenneur assessment criteria, there were excellent in six cases and good in one case. According to the U.S. Hospital for Special Surgery knee score, the efficacy was excellent. Results suggested that cannulated lag screws for Hoffa fracture were characterized by stable fixation, few complications, early functional exercises and good efficacy.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Percutaneous locking plate versus traditional anatomical plate fixation for distal tibial fracture
    Liu Chang-hai, Wang Zhan-chao, Lu Hua, Yu Si-ming, Mao Yu-lun, Zhou Qiang
    2014, 18 (17):  2703-2708.  doi: 10.3969/j.issn.2095-4344.2014.17.014
    Abstract ( 408 )   PDF (664KB) ( 436 )   Save

    BACKGROUND: Minimally invasive percutaneous plate osteosynthesis is characterized by indirect closed reduction of fracture, supplemented by suitable stable internal fixation, can protect blood supply in the fracture end and surrounding to the maximum, provide good biological environment, and have good curative effects on treatment of long bone shaft fracture.
    OBJECTIVE: To compare the clinical curative effects of minimally invasive percutaneous locking plate versus traditional anatomical plate fixation for distal tibial fracture.
    METHODS: A total of 68 patients with closed fracture of distal tibia, including 38 males and 30 females, aged 15-68 years old, were selected. In accordance with admission order and random ranked list, the patients were assigned to two groups. Minimal invasion group (n=32) received percutaneous locking plate fixation under the monitoring of C-arm X-ray machine. Traditional group (n=36) received common tibia compression plate and limited contact-dynamic compress plate fixation. The clinical curative effects were compared between the two groups.
    RESULTS AND CONCLUSION: Operation time, callus formation time, fracture union time, and time of restoring weight-bearing walking in the minimal invasion group were earlier compared with traditional group (P < 0.05), but intraoperative hemorrhage was less in the minimal invasion group than the traditional group (P < 0.05). After follow-up for 10-21 months, the excellent and good rate of limb function recovery was 97% in the minimal invasion group and 81% in the traditional group. Significant differences in the excellent and good rate were detectable between minimal invasion and traditional groups (P < 0.05). Results suggested that minimally invasive percutaneous locking plate fixation was in accorded with biological and mechanical principles, had less trauma, few complications in the incision and soft tissue, promoted fracture healing, and was an effective method to treat distal tibial fracture.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Posterior monosegment pedicle screw versus short segment pedicle screw instrumentation for type B thoracolumbar vertebral fracture
    Cui Shang-bin, Wei Fu-xin, Liu Shao-yu, Wang Le, Han Guo-wei, Huang Yang-liang
    2014, 18 (17):  2709-2715.  doi: 10.3969/j.issn.2095-4344.2014.17.015
    Abstract ( 330 )   PDF (1426KB) ( 306 )   Save

    BACKGROUND: Both the posterior monosegment pedicle screw instrumentation and the traditional posterior short segment pedicle screw instrumentation are common surgical methods for treating type B thoracolumbar fractures. However, their advantages, short-term and long-term surgical outcomes are still unclear.
    OBJECTIVE: To evaluate the stability of vertebra after posterior monosegment pedicle screw instrumentation and traditional posterior short segment pedicle screw instrumentation in the management of type B thoracolumbar fractures and the effects on intervertebral disc degeneration of adjacent segments.
    METHODS: We retrospectively analyzed 80 patients suffered from type B thoracolumbar fractures according to AO classification. The patients were divided into two groups according to the surgery they received. One was the traditional posterior short segment pedicle screw instrumentation group (n=45), and the other was posterior monosegment pedicle screw instrumentation group (n=40). The clinical therapeutic results were evaluated by measuring visual analogue scale score, ASIA classification, vertebral body compression rate, the index of vertebral canal occlusion, Cobb angle and UCLA arthritic grade respectively.
    RESULTS AND CONCLUSION: There were no statistical differences between the two groups in the ASIA neurological function classification, the occlusion index and the Cobb angle. However, operation time, bleeding amount, visual analogue scale scores, vertebral body compression rate and UCLA arthritic grade were better in the posterior monosegment pedicle screw instrumentation group than those in the traditional posterior short segment pedicle screw instrumentation group. Both the posterior monosegment pedicle screw instrumentation and traditional posterior short segment pedicle screw instrumentation showed great therapeutic results in the treatment of type B thoracolumbar fracture. The improvements in vertebral body compression rate and visual analogue scale scores were better in the posterior monosegment pedicle screw instrumentation group than those in the traditional posterior short segment pedicle screw instrumentation group. The posterior monosegment pedicle screw instrumentation also has many advantages such as less operation time, little trauma, preserving normal vertebrae segment and reducing intervertebral disc degeneration of adjacent segments.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Percutaneous pedicel screw fixation combined with vertebroplasty for thoracolumbar compression fractures
    Wang Qun, Sui Fu-ge, Wang Li-jing, Li Heng, Guo Ming-feng, Wang Qiang, Wang Dong-jun, Tian Guo-feng
    2014, 18 (17):  2716-2721.  doi: 10.3969/j.issn.2095-4344.2014.17.016
    Abstract ( 531 )   PDF (843KB) ( 534 )   Save

    BACKGROUND: Open reduction and internal fixation has been used widely in treatment of thoracolumbar fracture. This method needs to peel off muscle and soft tissues to expose bony marker and bone graft bed, so it induces bleeding and great injury. Minimally invasive technology has been aroused wide concern in spinal fracture.
    OBJECTIVE: To investigate the feasibility and efficacy of percutaneous pedicel screw fixation (Sextant) combined with vertebroplasty in treatment of thoracolumbar compression fractures.
    METHODS: A total of 32 patients with thoracolumbar compression fractures were selected from Department of Orthopedics of Longnan Hospital of Daqing City of Heilongjiang Province in China between September 2007 and May 2012. All the cases had no neurological symptoms below the injured plane. Decompression laminectomy was not required. They were equally divided into two groups. 16 patients of the Sextant group were treated by Sextant combined with vertebroplasty, 16 patients from the traditional open group were subjected to open surgery with classical pedicle screw fixation. The clinical and radiographic data were analyzed in both groups.
    RESULTS AND CONCLUSION: All cases were followed up for 12 to 38 months. After treatment, the height of fractured level and the kyphosis angle were restored. Compared with the traditional open group, less trauma, short operation time, less blood loss, short hospital stay and fast recovery were observed in the Sextant group. Results indicated that the technique of percutaneous pedicel screw fixation (Sextant) combined with vertebroplasty in treatment of thoracolumbar compression fractures is simple to operate, safe, reliable, has less trauma, less blood loss, light pain, fast recovery and short hospital stay.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Pedicle screw fixation combined with vertebroplasty for single-level thoracolumbar osteoporotic burst fractures
    Zhang Liang, Wang Jing-cheng, Feng Xin-min, Wang Yong-xiang, Yang Jian-dong, Tao Yu-ping, Zhang Sheng-fei, Huang Ji-jun
    2014, 18 (17):  2722-2727.  doi: 10.3969/j.issn.2095-4344.2014.17.017
    Abstract ( 350 )   PDF (865KB) ( 552 )   Save

    BACKGROUND: Vertebroplasty alone cannot relief spinal canal encroachment and kyphosis malformation for treatment of osteoporotic thoracolumbar fractures. Moreover, the occurrence rate of bone cement leakage is high, which becomes a contraindication for its application. Pedicle screw internal fixation alone may increase the trauma, screw loosening and high incidence of late kyphosis deformity.
    OBJECTIVE: To observe the therapeutic effects of short-segment pedicle screw fixation through paraspinal approach combined with vertebroplasty for single-level thoracolumbar osteoporotic burst fractures.
    METHODS: A retrospective study was conducted in 31 cases receiving short-segment pedicle screw fixation through paraspinal approach combined with vertebroplasty for single-level thoracolumbar osteoporotic burst fractures. After fixation, clinical outcomes were evaluated mainly with use of visual analog scale for lower back pain. Functions of lower back pain were assessed using Oswestry Disability Index questionnaire. Quality of life  was evaluated using 36-Item Short Form Health Survey. Thoracolumbar anteroposterior and lateral radiographs were utilized to assess anterior vertebral height ratio and the improvement of Cobb angle. Frankel score was applied to evaluate neurological function and complications.
    RESULTS AND CONCLUSION: All operations were successfully completed with no spinal cord or nerve damage. All patients were followed up for a mean 24.5 months (12-36 months). Fractured vertebrae reached satisfactory reduction. The average vertebral body height and Cobb angle significantly improved. The low back pain relieved. Low back function and quality of life improved significantly. All of the above indicators significantly improved (P < 0.05). No significant differences were detected between 1-week postoperation and 1-year postoperation (P > 0.05). After fixation, two patients affected bone cement leakage, including one in anterior vertebral body and one in intervertebral space. However, they did not have clinical symptoms. During follow-up, no loosening or breakage, no new fractures occurred. These results indicated that the combination of this technique with vertebroplasty plus internal fixation through paraspinal approach not only restored and maintained vertebral height and strength, reconstructed spinal stabilization, obviously lessened low back pain, but also could make patients get satisfactory low back function and improved the quality of life. It is an effective method for osteoporotic thoracolumbar fractures with spinal canal encroachment.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Pedicle screw systems for degenerative lumbar scoliosis with stenosis
    Wang Zhi-fang, Hu Zhen-ming, Hao Jie, Chen Lin, Wang Li-jun, Zhang Xiao-jun, Gan Qiang, He Bin
    2014, 18 (17):  2728-2733.  doi: 10.3969/j.issn.2095-4344.2014.17.018
    Abstract ( 392 )   PDF (908KB) ( 347 )   Save

    BACKGROUND: Simple vertebral canal decompression for degenerative lumbar scoliosis with stenosis cannot obtain long-period curative effects. Simple decompression is considered aiatrogenic destabilization of lumbar vertebra, and aggravates lumbar malformation.
    OBJECTIVE: To analyze the effectiveness of posterior decompression, fixation and fusion in the treatment of degenerative lumbar scoliosis with stenosis and to evaluate corrective angle during the follow-up.
    METHODS: A total of 23 cases of degenerative lumbar scoliosis with stenosis underwent posterior decompression, fixation and fusion. Visual Analogue Scale, Oswestry disability index, 36-Item Short-Form Health Survey scale and the Cobb angle on the lumbar coronal film were used to assess the changes in quality of life and corrective angle before treatment and during final follow-up.
    RESULTS AND CONCLUSION: All patients were followed up for at least 6 mouths. Mean Cobb angles were (23.94±11.4)° pretreatment and (10.28±6.93)° posttreatment. Mean Visual Analogue Scale scores were significantly lower posttreatment than pretreatment (P < 0.05). Oswestry disability index scores were significantly lower posttreatment than pretreatment (P < 0.05). The excellent and good rate of Oswestry disability index score was 83.33%. The eight scaled scores of 36-Item Short-Form Health Survey scale were significantly higher posttreatment than pretreatment (P < 0.05). During the follow-up, there was no obvious loss in corrective angle. Shift of interbody cages was not displaced. No internal fixator breakage appeared. The rate of fusion for bone graft was 100%.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    3.0 T magnetic resonance imaging diffusion-weighted imaging in evaluation of the reasons for lumbar disc degeneration
    Ma Xiao-hui, Zhang Wei, Gao Yu, Zhao Jian, Li Shi-ling, Zhang Xu-jing, Zhao Zhen-jiang, Jiang Zhen
    2014, 18 (17):  2734-2739.  doi: 10.3969/j.issn.2095-4344.2014.17.019
    Abstract ( 378 )   PDF (819KB) ( 429 )   Save

    BACKGROUND: Diffusion weighted imaging of MRI is sensitive for water molecule diffusion motion, can make us early understand the water content in annulus fibrosus and nucleus pulposus, so as to clarify its degeneration.
    OBJECTIVE: To elevate the knowledge of disc degeneration and early diagnosis using diffusion-weighted imaging of MRI by prospectively studying lumbar disc diffusion-weighted imaging in 109 patients.
    METHODS: Siemens Verio 3.0 T superconducting MRI was used. Conventional scan included sagittal T1WI and T2WI fat suppression sequence. Diffusion-weighted imaging used spin-echo echo planar imaging sequence sagittal scanning, taking b value of 800 s/mm2. Thickness, spacing, and field-of-view scan sequence was the same as fat suppression T2WI. According to Pfirrmann grading standard, the blind method was used in sagittal T2WI on 109 cases who met the inclusion criteria for classification of 545 lumbar intervertebral discs. The diffusion-weighted imaging data were uploaded to the station. Apparent diffusion coefficient images were measured, and the apparent diffusion coefficient values were obtained. Regions of interest of L1/2-L5/S1 discs  were drawn, and the data were recorded.
    RESULTS AND CONCLUSION: Age was obviously correlated with intervertebral disc degeneration grading. The older age indicated more number of higher grades. Influencing factors for apparent diffusion coefficient: no significant difference in apparent diffusion coefficient was detected between males and females (P > 0.05). L1-S1 intervertebral disc age was negatively associated with apparent diffusion coefficient values (P < 0.05). Disc rating was negatively correlated with apparent diffusion coefficient values (P < 0.05). Results indicated that diffusion-weighted imaging will become an important technical mean for disc degeneration diagnosis, especially early disc degeneration, noninvasive evaluation of treatment and prognosis by studying apparent diffusion coefficient values.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Spinal manipulative-oriented therapy for lumbar disc herniation: quantitative X-ray analysis on the involved vertebral segment
    Han Lei, Zhao Ping, Wang Fei, Wei Jie, Guo Wei
    2014, 18 (17):  2740-2745.  doi: 10.3969/j.issn.2095-4344.2014.17.020
    Abstract ( 442 )   PDF (978KB) ( 433 )   Save

    BACKGROUND: Functional lumbar scoliosis is a major symptom of lumbar disc herniation. The reason for its occurrence was strongly associated with the disorder of biomechanics of affected segment structure besides nerve root stimulus.
    OBJECTIVE: To analyze the mechanical impact of spinal manipulative therapy and other conservative treatment on functional scoliosis caused by lumbar disc herniation.
    METHODS: A total of 56 cases of lumbar disc herniation with functional scoliosis were consecutively selected in the study. The samples were mainly treated by spinal manipulation and conventional conservative therapy. After one course of treatment, the rotation and tilting angle of the involved vertebrae were quantitatively analyzed by Logan Spine X-Ray Software System. Simultaneously, the alterations in scores of Japanese Orthopaedic Association and Visual Analogue Scale were recorded.
    RESULTS AND CONCLUSION: The involved segment was proved abnormally coupled with the mechanical tendency of spine list by Logan Spine X-ray analysis, i.e., “uncompensated vertebrae” or “vertebral subluxation”. Moreover, there is a significant consistency with the troubled vertebra by palpation. After spinal manipulative therapy, the “uncompensated vertebrae” rotation reversed significantly and the segment was coupled normally with the mechanical tendency of functional scoliosis of lumbar spine. It could be an evidence of a rebuilt of “compensated vertebral segment”. The entire lumbar spine list was also noticeably reduced. These changes were significantly associated with the changes of Japanese Orthopaedic Association score and Visual Analogue Scale score. Results suggested that compensatory rebalance of the involved vertebral segment is significantly associated with symptomatology improvement in the patients with lumbar disc herniation. These indicated that it is of great clinical significance of correcting “uncompensated vertebrae” or “vertebral subluxation” to recover compensatory spinal balance as principle of spinal manipulation.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Characteristics of Micro CT images of adult Chinese lumbar isthmus at L5
    Liu Wei-hua, Tang Xi, Wang Zhi, Li Xin
    2014, 18 (17):  2746-2751.  doi: 10.3969/j.issn.2095-4344.2014.17.021
    Abstract ( 258 )   PDF (4446KB) ( 320 )   Save

    BACKGROUND: Currently, many scholars have made a large amount of studies on applied anatomy of adult Chinese lumbar isthmus at L5, but study results are diverse. Moreover, parameters were not systematic or complete. No control studies concerned the clinical applied anatomy and Micro CT imaging anatomy on adult Chinese lumbar isthmus at L5.
    OBJECTIVE: To observe and measure Micro CT imaging anatomy and applied anatomy on adult Chinese lumbar isthmus at L5 so as to provide morphological evidence for vulnerability of the adult Chinese lumbar isthmus at L5.
    METHODS: A total of 60 dried intact adult Chinese lumbar isthmus at L5 specimens were randomly obtained from the Laboratory of Regional Anatomy, Chengdu Medical College. Relevant data of lumbar isthmus at L5 were measured using vernier caliper. Three-dimensional bone architecture of lumbar isthmus at L5 was analyzed using Micro CT three-dimensional reconstruction system. Parameters of Micro CT imaging anatomy corresponding to the applied anatomy of left and right lumbar isthmus at L5 were measured.
    RESULTS AND CONCLUSION: Measurement on adult Chinese lumbar isthmus at L5 was performed: ① The thicknesses of upper border of left and right isthmus were respectively (4.27±0.99) mm and (4.25±0.98) mm. ② The thicknesses of lower border of left and right isthmus were respectively (7.31±1.23) mm and (7.29±1.25) mm. ③ The thicknesses of inner border of left and right isthmus were respectively (6.61±0.33) mm and (6.59±0.36) mm. ④ The thicknesses of exterior border of left and right isthmus were respectively (8.65±0.27) mm and (8.59±0.33) mm. ⑤ The distances of upper and lower borders of the left and right isthmus were respectively (11.10±3.14) mm and (11.07±3.11) mm. ⑥ The lengths of upper border of the left and right isthmus were respectively (8.37±0.99) mm and (8.40±0.96) mm. ⑦ The lengths of lower border of the left and right isthmus were respectively (4.71±0.71) mm and (4.73±0.62) mm. ⑧ The lengths of inner border of the left and right isthmus were respectively (13.01±1.38) mm and (13.04±1.36) mm. ⑨ The lengths of exterior border of the left and right isthmus were respectively (10.75±1.11) mm and (10.78±1.06) mm. No significant difference in the three-dimensional values of the left and right isthmus at L5 measured by vernier caliper and Micro CT was detected. Results verified that the measure values measured by vernier caliper and Micro CT on adult Chinese lumbar isthmus at L5 were uniform, and no significant difference was detectable between the left and right sides. Micro CT provides precise reference evidence for the vulnerability of L5 vertebra in the clinic.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    A meta-analysis of tranexamic acid to reduce blood loss in total hip arthroplasty
    Yin Yong, Ma Guang-wen, Huang Fei, Wang Qing, Wu Yun-feng
    2014, 18 (17):  2752-2757.  doi: 10.3969/j.issn.2095-4344.2014.17.022
    Abstract ( 450 )   PDF (924KB) ( 638 )   Save

    BACKGROUND: Tranexamic acid is a synthetic derivative of lysine, it can reversibly block the lysine binding sites on plasmin and plasminogen, thus playing anti-fibrinolytic effect. Tranexamic acid has been widely used in the treatment of cardiovascular surgery and is proven to effectively reduce blood loss.
    OBJECTIVE: To evaluate the effectiveness and safety of tranexamic acid treatment on reducing blood loss in total hip arthroplasty through a meta-analysis.
    METHODS: An online retrieval of Medline, PubMed, EMBASE, Cochrane Library, CNKI and VIP databases before September 2013 was performed for screening randomized controlled trials about the effect of tranexamic acid on blood loss in total hip arthroplasty. Meanwhile the references of the included literatures were manually checked. Statistical analysis was performed using RevMan5.0 software. The blood loss volume and blood transfusion volume in tranexamic acid group and placebo group were evaluated using the weighted mean difference. The incidence of transfusion rate and deep vein thrombosis were calculated using risk ratio in two groups.
    RESULTS AND CONCLUSION: A total of 16 randomized controlled trials involving 884 patients were included. Meta-analysis results showed that, tranexamic acid reduced total blood loss of patients after total hip arthroplasty, by a mean of 261.42 mL (95%CI -334.25 to -188.59, P < 0.000 01), intraoperative blood loss by a mean of 135.04 mL (95%CI -223.31 to -46.77, P < 0.01) and postoperative blood loss by a mean of 159.70 mL (95%CI -217.06 to -102.34, P < 0.000 01). Tranexamic acid also led to a significant reduction in transfusion requirements (RR 0.46, 95%CI 0.36 to 0.59, P < 0.000 01). There was no significant difference in the risk of deep vein thrombosis between the two groups. Tranexamic acid significantly reduces blood loss and blood transfusion requirements in patients undergoing total hip arthroplasty, and cannot increase the risk of deep vein thrombosis.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Early clinical efficacy in total knee arthroplasty: comparison of three types of prosthesis
    Zhang Zhong, Zhang Hai-sen, Zhang Bing, Zhang Ying-ze, Lü Long, Ma Shi-yun, Wang Huai-liang
    2014, 18 (17):  2758-2761.  doi: 10.3969/j.issn.2095-4344.2014.17.023
    Abstract ( 822 )   PDF (568KB) ( 405 )   Save

    BACKGROUND: The choice of prosthesis in total knee arthroplasty is still controversial.
    OBJECTIVE: To observe the early clinical efficacy of conventional fixation platform, rotation mobile platform and high-flexion prosthesis in total knee arthroplasty.  
    METHODS: The clinical data were analyzed retrospectively from patients undergoing primary total knee arthroplasty for osteoarthritis between January 2006 and December 2009. The KSS score, SF-36 score and maximal range of knee flexion in three groups were recorded at preoperative moment, postoperative 3, 6, 12 months and after 1 year.  
    RESULTS AND CONCLUSION: All the involved patients were followed up. Compared with preoperative data, postoperative KSS score, SF-36 score and maximal range of knee flexion were significantly improved after arthroplasty (P < 0.05). There was no significant difference in KSS score, SF-36 score and maximal range of knee flexion between three groups at the same time and among different groups at respective time (P > 0.05). These three kinds of prostheses showed good and excellent clinical efficacy for osteoarthritis, the patients were satisfied, and maximal range of knee flexion was improved. But there is no significant difference on early clinical efficacy, subjective satisfaction of patients and maximal range of knee flexion among the three kinds of prosthesis.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Anterior approach versus posterior approach for multilevel cervical spondylotic myelopathy: a meta-analysis
    Xie Chong, Jin Ge-le, Li Zhong-wei, Wang Peng, Zhao Xue-fei, Wang Kun, Geng Chong, Chen Bo
    2014, 18 (17):  2762-2769.  doi: 10.3969/j.issn.2095-4344.2014.17.024
    Abstract ( 562 )   PDF (826KB) ( 431 )   Save

    BACKGROUND: Currently, the treatment of multilevel cervical spondylotic myelopathy mainly contains anterior approach surgery and posterior approach surgery, but how to choose the incision is still controversial.
    OBJECTIVE: To compare the therapeutic effect and safety of anterior and posterior approaches for the treatment of multilevel cervical spondylotic myelopathy.
    METHODS: Databases such as MEDLINE, EMBASE, PubMed, Wanfang data and China National Knowledge Infrastructure were searched about related research and literature on anterior and posterior approaches for the treatment of multilevel cervical spondylotic myelopathy. Operative time, amount of blood loss, preoperative Japanese Orthopedic Association score, postoperative Japanese Orthopedic Association score, complication rate, degeneration rate of adjacent segments, cervical range of motion and reoperation rate were compared between anterior and posterior groups.
    RESULTS AND CONCLUSION: 12 studies were accorded with the inclusion criteria, totally containing 790 cases (359 cases in the anterior group, and 431 cases in the posterior group). Meta-analysis showed that no significant difference in preoperative Japanese Orthopedic Association score, operative time and intraoperative amount of blood loss was detected between the anterior posterior and posterior groups (P > 0.05). Compared with the posterior group, Japanese Orthopedic Association scores were higher (P < 0.001), degeneration rate of adjacent segments was higher (P=0.02), cervical range of motion was bigger (P=0.001), complication rate was higher (P=0.000 2), and the reoperation rate was higher (P < 0.000 1) in the anterior group postoperation. Results showed that surgical invasion between anterior and posterior surgical groups in treatment of cervical myelopathy was similar, but the neurological improvement of anterior group was better, while complication rate of posterior group was lower. Therefore, the choice of surgical approach should be based on clinical practice.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Meta analysis of flexion, extension and rotation of wrist joint in the elderly with distal radius fractures after treatment
    Nuerhanati•Shayilanbieke, Li Zhong-wei, Jin Ge-le, Yang De-sheng, Yang Yi
    2014, 18 (17):  2770-2776.  doi: 10.3969/j.issn.2095-4344.2014.17.025
    Abstract ( 323 )   PDF (802KB) ( 403 )   Save

    BACKGROUND: At present, it remains controversial whether open reduction plate fixation is needed for distal radius fracture in the elderly to restore anatomic reduction of imaging.
    OBJECTIVE: To systematically evaluate the curative effects of operative and nonoperative treatments for distal radius fractures in the elderly. 
    METHODS: We retrieved PubMed, Springer and Wanfang database using computer. Relevant English and Chinese journals of orthopedics were retrieved by hand. All literatures on curative effects of operative and nonoperative treatments for distal radius fractures in the elderly were collected. RevMan 5.0 software provided by Cochrane was used to statistically analyze the data.
    RESULTS AND CONCLUSION: Six literatures were included, including two of randomized controlled study and four of retrospective cohort study. Meta-analysis results displayed that there were no significant differences in both groups in range of motion of wrist joint extension [mean difference (MD)=-0.87, 95% confidence interval (CI) (-3.31, 1.58), P=0.49], range of motion of wrist joint flexion [MD=-2.79, 95%CI(-6.47, 0.88), P=0.14], range of motion of wrist pronation [MD=-0.08, 95%CI(-1.49, 1.64), P=0.92], range of motion of supination [MD=-0.7, 95% CI(-3.52, 2.12), P=0.63] and the occurrence of complication [MD=1.35, 95%CI(0.71, 2.56), P=0.36]. The length of radius in the surgery group was similar to that of normal [MD=2.46, 95%CI(1.78, 3.15), P < 0.01]. Ulnar inclination [MD=3.73, 95%CI(2.97, 4.48), P < 0.000 01] and palmar tilt angle [MD=6.81, 95%CI(3.72, 9.90), P < 0. 000 1] in the surgery group were close to that of normal. There are no significant differences in extension, flexion, pronation and supination activities of wrist and posttreatment complication between two groups. Operative treatment result is superior to that of nonoperative treatment in anatomic reduction.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Early functional exercises after arthroscopic rotator cuff repairs: a meta-analysis
    Shen Chong, Tang Zhi-hong, Hu Jun-zu, Zou Guo-yao, Xiao Rong-chi, Yan Dong-xue, Liu Rui-duan
    2014, 18 (17):  2777-2782.  doi: 10.3969/j.issn.2095-4344.2014.17.026
    Abstract ( 440 )   PDF (545KB) ( 377 )   Save

    BACKGROUND: At present, it remains unclear whether delayed functional exercises after arthroscopic rotator cuff repairs could elevate the healing rate of tendon. The opportunity of functional exercises after rotator cuff repairs is still controversial, and there is no relevant system evaluation.
    OBJECTIVE: To systematically evaluate the differences in curative effects of early and delayed functional exercises after arthroscopic rotator cuff repairs.
    METHODS: We searched the Pubmed, EMBASE, Cochrane Central Register of Controlled Clinical Trials, Chinese Biomedical Literature Database, Wanfang Data, China National Knowledge Infrastructure, and Chongqing VIP Database. The key words were “arthroscopy, rotator cuff, rehabilitation”. The references of the included literatures were re-retrieved. The deadline of retrieval was August 15, 2012. The included literatures were randomized controlled trials on early and delayed functional exercises after arthroscopic rotator cuff repairs. Methodological quality evaluation, screening and heterogeneous test were conducted. REVMAN5.1 software was utilized to analyze the extracted data.
    RESULTS AND CONCLUSION: We included three randomized controlled trials, including 237 patients: 119 in the early movement group and 118 in the delayed movement group. During follow-up at 1 year after operation, no significant differences in range of motion, pain degree, American Shoulder and Elbow Surgeons Scale, Simple Should Test scores and re-tear rate of rotator cuff were detected between the two groups. Results confirmed that compared with delayed functional exercises, early functional exercises after arthroscopic rotator cuff repair did not have advantages on the improvement of joint function and range of motion, but also did not negatively affect cuff healing. Postoperative rehabilitation can be modified to ensure patient’s compliance.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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    Fusion and non-fusion fixation for cervical spondylotic myelopathy: which is more appropriate for maintaining range-of-motion and stability of vertebrae?
    Shen Chao, Wang Wen-jun, Yan Yi-guo
    2014, 18 (17):  2783-2788.  doi: 10.3969/j.issn.2095-4344.2014.17.027
    Abstract ( 342 )   PDF (638KB) ( 367 )   Save

    BACKGROUND: In recent years, many scholars adopted a joint non-fusion and fusion spinal fixation for  multisegmental cervical spondylotic myelopathy, and achieved good clinical results. However, long-term clinical efficacy and possible related complications also require long-term follow-up of more in-depth study.
    OBJECTIVE: To review the research and application progress of anterior fusion and non-fusion fixation surgical operation for cervical myelopathy.
    METHODS: Computer-based search was conducted in China Journal Full-text Database and PubMed database by the first author for articles related to anterior fusion and non-fusion fixation surgical operation for cervical myelopathy published between January 2004 and January 2014. The key words were “implant material; cervical spondylotic myelopathy; anterior; surgery; fusion; non-fusion; progress; hybrid; summary” in Chinese and “implant material; cervical spondylotic myelopathy; anterior; surgery/operation; fusion; non-fusion; research progress; hybrid; summary” in English. Finally, 35 articles were included for review.
    RESULTS AND CONCLUSION: Fusion and non-fusion fixation methods for cervical spondylotic myelopathy had their own advantages. From the view point of indications, the non-fusion fixation was relatively limited. Currently, the fusion fixation was still the main method in treatment of cervical myelopathy. Non-fusion method as an emerging fixation method also achieved good short-period results, but it needs a long follow-up study. Hybrid fixation integrates the advantages of both methods, and can reduce the pressure. Simultaneously, Hybrid fixation also can reduce fusion segments, and retain the range-of-motion of the cervical spine as much as possible. Hybrid fixation becomes a hot topic in recent studies. However, most current researches on Hybrid fixation are retrospective study, lack of control. The overall follow-up time is short. Thus, Hybrid fixation needs to be researched more deeply.


    中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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