Correlation of trace element zinc with bone morphogenetic protein 7 and Stro-1+ cells in proximal femur: predicting hip prosthesis life

doi:10.3969/j.issn.2095-4344.2014.44.002

Abstract

Abstract:

BACKGROUND: The correlation of zinc with Stro-1⁺ cells and bone morphogenetic protein 7 surrounding the prosthesis may affect the bone fusion and survival rate in hip prosthesis.

OBJECTIVE: To analyze the correlation of zinc content with Stro-1⁺ cells and bone morphogenetic protein 7 in proximal femur.

METHODS: Bone samples were obtained from the discarded metaphysis region of the proximal femur in 24 patients with primary total hip replacement. Bone marrow mesenchymal stem cells were cultured in vitro. At 14 days after culture, Stro-1⁺ cells in bone marrow mesenchymal stem cells were detected using flow cytometry. Bone morphogenetic protein 7 expression in cell supernatant was detected using enzyme-linked immunosorbent assay. Zinc content in supernatant was measured using radio-immunity assay.

RESULTS AND CONCLUSION: No significant difference in the zinc content was detected in different age groups and different gender groups. Zinc content was positively associated with Stro-1⁺ cells and bone morphogenetic protein 7 expression. The further study of the trace element zinc in proximal femur can predict and intervene the longevity of hip prosthesis.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

Key words: joint replacement, hip, bone marrow mesenchymal stem cells, bone morphogenetic protein 7

CLC Number:

R318

Fu Xiao-dong, Wang Wei-li, Shen Yi, Li Xiao-miao. Correlation of trace element zinc with bone morphogenetic protein 7 and Stro-1⁺ cells in proximal femur: predicting hip prosthesis life[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(44): 7061-7065.

Figures/Tables 3

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