Trifluoperazine decreases scar thickness in a rabbit model of hypertrophic scar ear

doi:10.3969/j.issn.2095-4344.2014.36.005

Abstract

Abstract:

BACKGROUND: Conventional treatments for hypertrophic scars include excision, steroid hormones, anti-metabolite drugs, immunosuppressive agents and radiation therapy. Easy to relapse or serious reaction limits their clinical use. In recent years, application of calcium channel blockers in treatment of hypertrophic scars has made more good progresses, but little adverse reactions are obtained.
OBJECTIVE: To explore the effects of calcium channel blocker trifluoperazine on hypertrophic scar of rabbit ears.
METHODS: A total of 24 rabbits were enrolled in this study. After 1 week of accommodation, models of rabbit ear scar were established in accordance with the method of Morris and Li et al. Rabbit models were randomly assigned to three group (n=8). At 30 days after model induction, when scar formed, trifluoperazine and triamcinolone acetonide groups received trifluoperazine and triamcinolone acetonide injection. Blank control group was left intact. Changes in hyperplastic scar, hypertrophic index, levels of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-2, transforming growth factor β1, α-smooth muscle actin and proliferating cell nuclear antigen were compared and observed in each group.
RESULTS AND CONCLUSION: At 10 and 20 days after treatment, in the three groups, skin bulge was visible in rabbit ears and no rabbit hair grew. Rabbit ears had obvious softening in the trifluoperazine group compared with the triamcinolone acetonide group, showing dark red. In the blank control group, rabbit ear scar was evident and showed red color. At 20 days after treatment, scar thickness and scar index were lower in the trifluoperazine and triamcinolone acetonide groups than in the blank control group. Matrix metalloproteinase 2 expression was significantly higher, but tissue inhibitor of metalloproteinase-2 and transforming growth factor β1 levels were lower in the trifluoperazine and triamcinolone acetonide groups than in the blank control group. Results indicated that trifluoperazine obtained good proliferative effects on rabbit ear scar, and could decrease scar thickness.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: trifluoperazine, cicatrix, matrix metalloproteinase-2, transforming growth factor beta 1, proliferating cell nuclear antigen

CLC Number:

R318

Guan Jian, Wang Ye. Trifluoperazine decreases scar thickness in a rabbit model of hypertrophic scar ear[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(36): 5764-5769.

Figures/Tables 5

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