Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (39): 5885-5891.doi: 10.3969/j.issn.2095-4344.2016.39.017

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Comparison of 3.0T MRI and SPECT-CT in the diagnosis of osteoporotic vertebral compression fractures

Ding Chao, Sun Qiang, Tang Cheng   

  1. Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
  • Revised:2016-07-12 Online:2016-09-23 Published:2016-09-23
  • Contact: 孙强,副教授，南京医科大学附属南京医院骨科，江苏省南京市 210006
  • About author:Ding Chao, Studying for master’s degree, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, Jiangsu Province, China

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Abstract:

BACKGROUND: There have been many studies on the diagnosis of osteoporotic vertebral compression fractures. However, there are few studies on the diagnostic methods of fracture in different periods.

OBJECTIVE: To comparatively analyze the application value of high-intensity magnetic resonance imaging (MRI) and single photon emission computed tomography combined with CT scan image fusion (SPECT-CT) in the diagnosis of osteoporotic vertebral compression fractures.
METHODS: Clinical data of 35 patients with osteoporotic vertebral compression fractures were retrospectively analyzed, including 56 vertebrae. There were 14 males and 21 females, with an average age of 72.6 years. The course of disease was within 3 weeks in 22 patients, belonging to acute fractures. The course of the disease was between 4 and 12 weeks in 10 patients, belonging to the subacute fractures. The course of disease was 6 months in 3 patients, belonging to the fracture healing period. All patients were tested with high-intensity MRI and SPECT-CT examination, and were treated with vertebroplasty or percutaneous kyphoplasty. The Fisher exact method was used to compare the two diagnostic methods in the diagnosis of vertebral fracture.
RESULTS AND CONCLUSION: (1) In the 56 responsible vertebral bodies, 32 vertebral bodies belonged to the acute-stage fractures, and 24 vertebral bodies belonged to the non-acute-stage fractures. In all the fractures, MRI diagnosed 49 segments; SPECT-CT diagnosed 52 segments. The sensitivity of SPECT-CT testing was higher than MRI, and its specificity was less than MRI. There was a high consistency of diagnosis between fractures. (2) In the 32 acute vertebral fractures, the two tests diagnosed 29 segments. The sensitivity of SPECT-CT was higher than that of MRI, but its specificity was lower than that of the MRI. There was a high consistency between the diagnoses of fractures. (3) In the 24 non-acute vertebral fractures, MRI diagnosed 20 segments; SPECT-CT diagnosed 23 segments. SPECT-CT was more sensitive than MRI; the specificity of SPECT-CT was lower than MRI. There was a high consistency between the two diagnoses of fractures. (4) There was a high consistency in the MRI and SPECT-CT examination to determine the fracture of different periods of responsibility of the vertebral body, but the sensitivity of SPECT-CT is higher than MRI examination; SPECT-CT is an effective inspection method in the diagnosis of vertebral fractures.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Magnetic Resonance Imaging, Cicatrix, Hypertrophic, Tissue Engineering

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