Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (14): 2481-2486.doi: 10.3969/j.issn.1673-8225.2012.14.003

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Effects of bone marrow mesenchymal stem cells on vascularization of hepatoma models of rats

Song Hao1, Ji Wei-zheng2, Tai Qin-wen1, Shan Jiao-yu3, Zhang Jin-hui1     

  1. 1Department of Endoscope of Liver Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China; 2Department of Interventional Radiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China; 3Department of Parasitology, Basic Medical School, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-08-30 Revised:2011-09-23 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Zhang Jin-hui, Chief physician, Professor, Master’s supervisor, Department of Endoscope of Liver Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China zhangjinhui2001@yahoo.com
  • About author:Song Hao★, Studying for master’s degree, Department of Endoscope of Liver Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China songhao.amos2009@163.com
  • Supported by:

    Science Foundation of the First Affiliated Hospital of Xinjiang Medical University, No. 2009GXB02*

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Abstract:

BACKGROUND: There are few reports about the effects of bone marrow mesenchymal stem cells (BMSCs) transplantation on vascularization during hepatocarcinogenesis in rats.
OBJECTIVE: To observe the effects of BMSCs transplantation on vascularization during hepatocarcinogenesis in rats.
METHODS: Thirty Wistar rats were divided into BMSCs transplantation group, pure model group and blank control group randomly. The first two groups were treated with diethylnitrosamine to prepare hepatoma models. The blank control group was treated with water as control.
RESULTS AND CONCLUSION: Eight rats in the pure model group and nine rats in the BMSCs transplantation group were proved to be with liver cancer, and the SrY+ cells were seen in the BMSCs transplantation group. MRI showed that there were more space-occupying lesions in the liver of the BMSCs transplantation group compared with the pure model group (t = 2.45, P = 0.026). The average positive expression rate of vascular endothelial growth factor and microvessel density in the BMSCs transplantation group were higher than those in the pure model group (P < 0.05). In the hepatoma models of rats prepared with diethylnitrosamine, BMSCs can promote the vascularization resulting in the development of liver cancer.

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