Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7709-7712.doi: 10.3969/j.issn.2095-4344.2012.41.022

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Effect of bone marrow mesenchymal stem cells on vascular endothelial growth factor expression in the aging heart of rats

Li Yan-ju1, Liu Yang2, Guo Kun-yuan3   

  1. 1Department of Hematology, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China
    2Academy of Military Medical Sciences, Beijing 100850, China
    3Department of Hematology, Zhujiang Hospital, Guangzhou 510282, Guangdong Province, China
  • Received:2012-01-03 Revised:2012-02-18 Online:2012-10-07 Published:2013-04-09
  • Contact: Guo Kun-yuan, M.D., Doctoral supervisor, Department of Hematology, Zhujiang Hospital, Guangzhou 510282, Guangdong Province, China wodeyoujian@foxmail.com
  • About author:Li Yan-ju☆, M.D., Department of Hematology, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China lyj8181@163.com

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Abstract:

BACKGROUND: Vascular endothelial growth factors secreted by bone marrow mesenchymal stem cells may exhibit therapeutic effects on the aging heart. However, whether the therapeutic effects are associated with bone marrow mesenchymal stem cells homing to the heart?
OBJECTIVE: To investigate the effects of bone marrow mesenchymal stem cells on aging heart.
METHODS: Rat bone marrow mesenchymal stem cells were harvested. Forty rats were randomly divided into four groups: normal, model, treatment and fluorescence labeling. Rats in the latter three groups were subcutaneously injected with D-galactose to establish aging heart rat models. Rats in the latter two groups were injected with non-labeled or carboxyflu-orescein diacetate succinimidyl ester-labeled bone marrow mesenchymal stem cells. Cell location, cardiac tissue factor expression were investigated.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells could arrive at the aging heart. Compared with the model group, the activity of superoxide dismutase in the serum and heart tissue was significantly increased, the level of malondialdehyde was significantly decreased (P < 0.05), and vascular endothelial growth factor expression in the cardiac tissue was significantly increased after treatment with bone marrow mesenchymal stem cells. These findings suggest that bone marrow mesenchymal stem cells can secrete vascular endothelial growth factors, which may be one of mechanisms by which bone marrow mesenchymal stem cells contribute to improvement of aging heart.

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