Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7881-7884.doi: 10.3969/j.issn.1673-8225.2011.42.022

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Systematical evaluation for the biocompatibility of biodegradable cerebrovascular stent materials

Qu Hao1, Li Mei1, Yuan Ping2, Guo Qin3   

  1. 1Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang  550000, Guizhou Province, China
    2Pediatric School of Chongqing Medical University, Chongqing  400020, China
    3Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou  510405, Guangdong Province, China
  • Received:2011-08-01 Revised:2011-09-16 Online:2011-10-15 Published:2011-10-15
  • Contact: Li Mei, Chief physician, Department of Medical Cadres, Guizhou Provincial People’s Hospital, Guiyang 550000, Guizhou Province, China gychenlan2011@ gmail.com
  • About author:Qu Hao, Associate chief physician, Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550000, Guizhou Province, China gychenlan2011@ gmail.com

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Abstract:

BACKGROUND: To select and develop cerebrovascular stent materials with a good biocompatibility is currently a hot research
OBJECTIVE: To systematically evaluate the biocompatibility of biodegradable cerebrovascular stent materials, and to analyze the safety and prognosis after stent implantation.
METHODS: A computer-based online search of EMbase (1980/2011-08), MEDLINE (1966/2011-12), CBM (1978/2011-08) and CNKI were performed for articles about animal experiments and clinical applications focusing on the biocompatibility of biodegradable cerebrovascularr stent materials. 
RESULTS AND CONCLUSION: Of 24 selected articles, 15 related animal experiments results show that various types of biodegradable cerebrovascularstent with good biocompatibility have favorable effects on preventing vascular thrombosis and restenosis by suppressing endometrial hyperplasia. Nine related clinical experiments results show that biodegradable cerebrovascular stents can decrease the rate of restenosis and improve patients’ prognosis; however, the safety needs long-term studies. Biodegradable cerebrovascular stent materials with good biocompatibility are effective and safe for cerebrovascular diseases. Further studies with long-term follow-up are required to assess the restenosis rates in the intracranial vasculature.

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