Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7887-7891.doi: 10.3969/j.issn.1673-8225.2011.42.024

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Research progress of nano-hydroxyapatite composite scaffolds

Zhang Jin-peng, Tang Xun   

  1. Department of Orthopedics, Kunming General Hospital of Chengdu Military Command of Chinese PLA, Clinical College of Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Received:2011-04-26 Revised:2011-08-01 Online:2011-10-15 Published:2011-10-15
  • Contact: Tang Xun, Master, Professor, Chief physician, Department of Orthopedics, Kunming General Hospital of Chengdu Military Command of Chinese PLA, Clinical College of Kunming Medical College, Kunming 650032, Yunnan Province, China tangxun657@ 126.com
  • About author:Zhang Jin-peng★, Studying for master’s degree, Department of Orthopedics, Kunming General Hospital of Chengdu Military Command of Chinese PLA, Clinical College of Kunming Medical College, Kunming 650032, Yunnan Province, China yefei182@126.com
  • Supported by:

    the Science and Technology Plan Projects Foundation of Yunan Province, No. 2010BC006*

Abstract:

BACKGROUND: Hydroxyapatite has been widely used as reconstructive and prosthetic material for osseous tissue, owing to its excellent biocompatibility and bioactivity. But, its brittleness is one of the most serious obstacles for its wider applications as load-bearing implants.
OBJECTIVE: To review various hydroxyapatite composites and the research progress in this field.
METHODS: Articles were searched in PubMed database (1995-01/2010-10) and CNKI Database (1995-01/2010-10) with the keywords of “nano-hydroxyapatite, composites” in English and Chinese, respectively. Repetitive studies and non-relevant studies were excluded. And 33 papers were included in result analsysis.
RESULTS AND CONCLUSION: With the development of nanotechnology, components of nano-hydroxyapatite composites are optimized. Experimental results have showed their superiority that nano-hydroxyapatite composites could mimic natural bone and extracellular matrix well. Simultaneously, the preparation method needs further optimization, the combination between nano-hydroxyapatite and polymer need to be improved so as that nano-hydroxyapatite composites have the best mechanical property, best processability and best biological property, then meeting the requirements of clinical applications.

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