Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7805-7808.doi: 10.3969/j.issn.1673-8225.2011.42.004

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Repairing rabbit radial bone defects by porous titanium

Zhang Hong-fang1, Zhao Chao-yong2, Fan Hong-song2, Zhang Hui1, Pei Fu-xing1, Wang Guang-lin1   

  1. 1Department of Orthopedics, West China Hospital, Sichuan University, Chengdu  610041, Sichuan Province, China
    2National Engineering Research Center for Biomaterials, Sichuan University, Chengdu  610064, Sichuan Province, China
  • Received:2011-02-09 Revised:2011-04-13 Online:2011-10-15 Published:2011-10-15
  • Contact: Wang Gang-lin, Doctor, Associate professor, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Zhang Hong-fang★, Master, Attending physician, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China Zhf716@163.com
  • Supported by:

    the National Key Basic Research Program of China (973 Program), No. G2005cb623901*; the National Key Science and Technology Research Foundation of China, No. 2006BAI16B01*

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Abstract:

BACKGROUND: Usage of porous titanium in the repair of bone defects in animal models has been reported. 
OBJECTIVE: To investigate the therapeutic effects of porous titanium on the recovery of rabbit radial bone defects.
METHODS: A total of healthy 21 New Zealand rabbits were artificially made to be bone defect models by resecting the 1 cm substantial ossea with periosteum of both radii. The left anterior limbs were implanted porous titanium, while the right anterior limbs were implanted porous hydroxyapatite (HA).
RESULTS: ①The gross observation and X-ray results demonstrated that there was a little callus filled in the juncture of materials and autogenous bone both in the left and right anterior limbs 4 weeks after the operation. At 8 and 16 weeks, the materials in the both sides were filled by newly formed bone, and the anastomosis status was good. ②The histology examination showed that mass newly formed bone grew into most pores of both specimens. Along with prolongation of times after operation, the ingrowths of bone cells and effect of bone remodeling in the affected side were nearly as same as the control side at 8 and 16 weeks. The results of histomorphometrical analysis showed that a statistically significant difference was not obtained for % bone area (bone area/gross implant) between the both groups (P > 0.05). ③However, the results of maximum failure load in the affected side were better than those of the control side at 8 and 16 weeks. Osteogenesis can be promoted by porous titanium, which is an appropriate tool to induce the healing of segmental bone defects.

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