Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7812-7812.doi: 10.3969/j.issn.1673-8225.2011.42.005

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Dibutyl phthalate-induced testicular histopathological changes in mice

Bai Chen1, Zhang Ci1, Du Xian-jin2, Zhou Xiang-jun1, Zhou Yi3   

  1. 1Department of Urological Surgery, 2Department of Emergency, 3Animal Room, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
  • Received:2011-04-02 Revised:2011-05-10 Online:2011-10-15 Published:2011-10-15
  • Contact: Zhang Ci, Doctor, Associate chief physician, Department of Urological Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China urology@163. com
  • About author:Bai Chen★, Master, Department of Urological Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China 6807050xiaobai@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30972989*

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Abstract:

BACKGROUND: In most studies about the reproduction harm of dibutyl phthalate (DBP), the objects are mostly rats. There are no histological changes in mice as well as clear implantation time.
OBJECTIVE: To discuss the testicular histopathological changes of mice induced by DBP, and to find the time point when the changes are greatest.
METHODS: Twenty pregnant balb/c mice were randomly divide into 3 groups: 6 in normal control group, 6 in corn oil control group, and 8 in DBP group. From pregnancy 12 days to 21 days, DBP and the corn oil were orally administrated. The histopathological changes were observed in newborn mice at 4-8 weeks after birth to find the greatest change point.
RESULTS AND CONCLUSION: The DBP group presented with obvious physiopathological changes under the electron microscope. DBP could cause abnormal sexual differentiation in male mice, which were seminaferous epithelium thick and testicle dyszoospermia. DBP had the worst effect on the testis of mice at 5-6 weeks after birth.

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