Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7801-7804.doi: 10.3969/j.issn.1673-8225.2011.42.003

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Osteoprotegerin and basic fibroblast growth factor combination enhances the restoration of alveolar bone defects in dogs

Cao Yin1, He Shi-hai2, Chen Qiao-er2, 3   

  1. 1Department of Periodontium, Changzhou Stomatology Hospital, Changzhou  213003, Jiangsu Province, China
    2School of Stomatology, Anhui Medical University, Hefei  230032, Anhui Province, China
    3Anhui Provincial Laboratory of Oral Disease Research, Hefei  230032, Anhui Province, China
  • Received:2011-04-19 Revised:2011-05-16 Online:2011-10-15 Published:2011-10-15
  • Contact: Chen Qiao-er, Master, Professor, School of Stomatology, Anhui Medical University, Hefei 230032, Anhui Province, China; Anhui Provincial Laboratory of Oral Disease Research, Hefei 230032, Anhui Province, China chqe0111@ 163.com
  • About author:Cao Yin★, Master, Attending physician, Department of Periodontium, Changzhou Stomatology Hospital, Changzhou 213003, Jiangsu Province, China ycao20032@ yahoo.com.cn
  • Supported by:

    the Social Development Foundation of Changzhou City, No. CS20092023*

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Abstract:

BACKGROUND: A variety of growth factors are effective in promoting periodontal tissue regeneration.
OBJECTIVE: To explore the restoration of alveolar bone defects with recombinant adenovirus encoding osteoprotegerin and basic fibroblast growth factor.
METHODS: Class Ⅲ furcation defects were created in the mandibular premolars. The osteoprotegerin and basic fibroblast growth factor combination with adenovirus was covered on the defects in the experimental group, while in the control group only with adenovirus or nothing.
RESULTS AND CONCLUSION: Four weeks after operation, the difference between the experimental group and the control group was indistinctive. Twelve weeks after operation, the new bone filled almost the entire circumference of the furcation in the experimental group, while the quantity of the new bone was less in the control group. Combination of osteoprotegerin and basic fibroblast growth factor could promote alveolar bone regeneration.

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