Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 5987-5990.doi: 10.3969/j.issn.1673-8225.2011.32.022

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Effect and safety of umbilical cord mesenchymal stem cells transplantation on end-stage liver cirrhosis

Zhou Bing-xi, Guo Jun-xian, Han Shuang-yin, Zhang Yan-rui   

  1. Department of Digestion, Henan Provincial People’s Hospital, Zhengzhou  450003, Henan Province, China
  • Received:2011-06-08 Revised:2011-07-04 Online:2011-08-06 Published:2011-08-06
  • About author:Zhou Bing-xi★, Master, Associate chief physician, Department of Digestion, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China zhoubingxi@medmail.com.cn

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Abstract:

BACKGROUND: Bone mesenchymal stem cells (BMSCs) transplantation has been used for end-stage liver cirrhosis, and obtained some results.
OBJECTIVE: To observe the effect and safety of umbilical cord mesenchymal stem cells (UCMSCs) transplantation on end-stage hepatic cirrhosis.
METHODS: UCMSCs were isolated under sterile conditions. Sixty cases of liver cirrhosis received basic medication and UCMSCs transplantation by way of hepatic artery.
RESULTS AND CONCLUSION: After UCMSCs treatment, the level of albumin, prealbumin and fibrinogen were significantly increased (P < 0.05), and the levels of total bilirubin and prothrombin time were obviously reduced (P < 0.05). The symptoms such as fatigue, abdominal distension, anorexia relieved after treatment. UCMSCs transplantation for end-stage liver cirrhosis is safe and effective, and it can improve patients’ liver function, blood clotting and relieve clinical symptoms.

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