Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 5991-5994.doi: 10.3969/j.issn.1673-8225.2011.32.023

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Effects of intravenous transplantation of umbilical blood mesenchymal stem cells on cerebral edema secondary to hematoma in neonatal rats

Yan Xiao-hua1, Chen Qi-wen1, Xu Xin1, Li Yan-cheng2, Yan Shao-ming3, Huang Zhen-gang1, Zhang Li-na1   

  1. 1Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China
    2Department of Internal Medicine, Jiaotong Hospital of Jiangxi Province, Nanchang  330003, Jiangxi Province, China
    3Department of Pediatrics, Yongfeng County People’s Hospital, Ji’an  331500, Jiangxi Province, China
  • Received:2011-02-21 Revised:2011-05-22 Online:2011-08-06 Published:2011-08-06
  • About author:Yan Xiao-hua☆, Doctor, Associate chief physician, Associate professor, Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China yanxiaohua456@yahoo.com.cn Chen Qi-wen, Associate chief physician, Associate professor, Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China xymu2001phd@yahoo.com
  • Supported by:

    Support Program Research Fund of Jiangxi Science and Technology Bureau, No. [2009]247*

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Abstract:

BACKGROUND: There are few reports about human umbilical cord blood mesenchymal stem cells (HUCBMSCs) for cerebral edema secondary to hematoma in neonatal animals.
OBJECTIVE: To study the possibility of intravenous transplantation of HUCBMSCs in the treatment of cerebral edema secondary to hematoma in neonatal rats.
METHODS: Neonatal rats aged 7 days were randomly assigned into three groups: normal control, model group and MSCs transplantation group. One week after transplantation, the rats in each group were randomly killed to extract brain tissues which were used pathomorphology observation and index measurement.
RESULTS AND CONCLUSION: Both brain coefficient and water content of brain tissue were significantly lower in the MSCs group than the model group (P < 0.01). However, there was no difference between MSCs group and control group (P > 0.05). There was no difference in the death rate of rats in each group 1 week after the implantation. The brain damage to most of the rats in this group was not serious but only slight by chance, close to the normal at the one week after implantation. HUCBMSCs transplantation could effectively decrease the brain edema and ameliorate the damaged brain tissue. One week after transplantation, the MSCs appeared in the ischemic damaged brain tissue as a large number of MSCs could cross the blood brain barrier to distribute and scatter around the disease focus integrated with host brain tissue without apparent threshold.

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