Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 5936-5940.doi: 10.3969/j.issn.1673-8225.2011.32.011

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Comparison of the biological characteristics of bone marrow and adipose tissue derived mesenchymal stem cells

Zhu Xi-shan, Shi Wei, Tai Wei-ping, An Guang-yu   

  1. Department of Tumor, Beijing Shijitan Hospital, Capital Medical University (The 9th Hospital of Peking University), Beijing  100038, China
  • Received:2011-03-07 Revised:2011-06-13 Online:2011-08-06 Published:2011-08-06
  • About author:Zhu Xi-shan☆, Doctor, Department of Tumor, Beijing Shijitan Hospital, Capital Medical University (The 9th Hospital of Peking University), Beijing 100038, China zhuxishan@tsinghua.org.cn

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Abstract:

BACKGROUND: Recently, adipose tissue derived mesenchymal stem cells due to easy to be harvested have been widely studied.
OBJECTIVE: To compare the biological characteristics of adipose tissue derived mesenchymal stem cells and bone marrow mesenchymal stem cells.
METHODS: Adipose tissue derived mesenchymal stem cells and bone marrow mesenchymal stem cells were isolated and cultured in vitro to compare their phenotype, cell doubling time and the level of secreted factors.
RESULTS AND CONCLUSION: Adipose tissue derived mesenchymal stem cells have similar phenotype and differentiation ability as bone marrow mesenchymal stem cells except CD106 expression. The frequency of mesenchymal stem cells in bone marrow and adipose tissue was also calculated and found that mesenchymal stem cells frequency in adipose tissue was 10 times higher than bone marrow. This result can be an instruction for mesenchymal stem cells clinical use.

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