Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 5941-5944.doi: 10.3969/j.issn.1673-8225.2011.32.012

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Neuroprotective effect of mild hypothermia on the proliferation of endogenous neural stem cells in rats with intracerebral hemorrhage

Zhang Jun1,2, Zhu Ping3, Wang Lian-kun4, Hou Dan-hui1, Wang Ying2, Wang Kun-xiang5   

  1. 1Department of Neurology, the Fourth Clinical Hospital of Harbin Medical University, Harbin  150001, Heilongjiang Province, China
    2Department of Neurology, the First Clinical Hospital of Harbin Medical University, Harbin  150001, Heilongjiang Province, China
    3Department of Emergency, Harbin Red Cross Central Hospital, Harbin 150000, Heilongjiang Province, China
    4Department of Neurology, Heilongjiang Provincial Hospital, Harbin  150001, Heilongjiang Province, China
    5the First Clinical Hospital of Jiamusi Medical University, Jiamusi  154001, Heilongjiang Province, China
  • Received:2011-04-25 Revised:2011-06-21 Online:2011-08-06 Published:2011-08-06
  • About author:Zhang Jun★, Master, Attending physician, Department of Neurology, the Fourth Clinical Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China; Department of Neurology, the First Clinical Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China hljzhangjun@yahoo.com.cn
  • Supported by:

    the Science and Technology Project of Education Department of Heilongjiang Province, No. 11541152*

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Abstract:

BACKGROUND: There are a few reports addressing application of mild hypothermia to brain edema after intracerebral hemorrhage, but few reports have addressed mild hypothermia effects on proliferation of neural stem cells in the brain following intracerebral hemorrhage.
OBJECTIVE: To explore the effects of mild hypothermia on proliferation of neural stem cells of rats after intracerebral hemorrhage.
METHODS: A model of intracerebral hemorrhage was established by autologous arterial blood injected into right caudate nucleus. Local mild hypothermia was applied in the mild hypothermia group for 4 hours after the blood injected in the brain. Normal body temperature was maintained in control group.
RESULTS AND CONCLUSION: At 1, 3, 7, 14 days after intracerebral hemorrhage, the Longa score in the hypothermia group was lower than that in the control group (P < 0.05). At various time points following intracerebral hemorrhage, the number of BrdU-positive cells was obviously greater in the hypothermia group compared with the control group (P  < 0.05). Results had indicated that mild hypothermia can promote the proliferation of neural stem cells, and shows neuroprotective effects on intracerebral hemorrhage.

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