Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (45): 8453-8459.doi: 10.3969/j.issn.2095-4344.2012.45.017

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Treatment of early osteonecrosis of femoral head with autologous stem cells transplantation by computer navigat

Cui Da-ping1, 2, Zhao De-wei1, 2   

  1. 1Telecommunications College, Dalian University of Technology, Dalian 116085, Liaoning Province, China
    2Department of Orthopedics, Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
  • Received:2012-08-22 Revised:2012-09-03 Online:2012-11-04 Published:2012-11-04
  • Contact: Zhao De-wei, Doctor, Chief physician, Telecommunications College, Dalian University of Technology, Dalian 116085, Liaoning Province, China; Department of Orthopedics, Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China deweizhao.dush@gmail.com
  • About author:Cui Da-ping★, Master, Associate chief physician, Telecommunications College, Dalian University of Technology, Dalian 116085, Liaoning Province, China; Department of Orthopedics, Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China cuidaping@126.com

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Abstract:

BACKGROUND: How to use the tissue engineering technique to repair the cartilage with femoral head collapse is the main research direction in the treatment of the femoral head necrosis after collapse.
OBJECTIVE: To observe the therapeutic effect of in vitro cultured autologous bone marrow mesenchymal stem cells transplantation on the treatment of early osteonecrosis of femoral head by computer navigation and arthroscopy.
METHODS: 104 patients with early osteonecrosis of femoral head were collected according to the international classification of osteonecrosis of Association Research Circulation Osseous, all the patients received the core decompression under the aids of computer navigation, and the necrosis debridement was performed under arthroscopy. Among them, 53 patients received phase two transplantation of 2 mL in vitro isolated and cultured bone autologous bone marrow mesenchymal stem cells at 1×109 /L.
RESULTS AND CONCLUSION: After 30 months follow-up and magnetic resonance examination, the femoral head necrosis volume of all patients were reduced significantly, and the Harris score was increased significantly (P < 0.05); the femoral head necrosis volume and Harris score of the patients with autologous bone marrow mesenchymal stem cells transplantation were improved more significantly (P < 0.05), the clinical success rate and radiographic success rate was 92% and 90%, respectively; no obvious adverse reactions were observed. Core decompression and autologous bone marrow mesenchymal stem cells in vitro culture and transplantation by computer navigation and arthroscopy is a safe and effective method for the treatment of early avascular necrosis of femoral head, and the effect is better than the core decompression.

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