Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2838-2841.doi: 10.3969/j.issn.1673-8225.2011.15.043

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Cerebral protection with lidocaine following cardiac surgery: A meta-analysis

Wang Dong-jin1, Nie Ling2, Wang Ying-chun3   

  1. 1Department of Cardio-Thoracic Surgery, Nanjing Drum Tower Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing  210008, Jiangsu Province, China
    2Department of Cardio-Thoracic Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing  210008, Jiangsu Province, China
    3School of Traditional Chinese Medicine, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2010-10-06 Revised:2010-11-29 Online:2011-04-09 Published:2013-11-06
  • Contact: Nie Ling, Attending physician, Department of Cardio-Thoracic Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
  • About author:Wang Dong-jin☆, Doctor, Master’s supervisor, Chief physician, Department of Cardio-Thoracic Surgery, Nanjing Drum Tower Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, Jiangsu Province, China dong-jinwang@ hotmail.com

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Abstract:

BACKGROUND: Although cardiac surgery becomes more mature, the ratio of cognitive deficits after surgery is still remains high. Some reports showed that lidocaine has neuroprotective effect, but their results are not totally identical.
OBJECTIVE: To assess the neuroprotective effect of lidocaine in cardiac surgery.
METHODS: A systematic literature search of PubMed, Cochrane databases, CNKI and Ovid was performed to identify relevant prospective randomized studies. The therapeutic effect and difference were evaluated using the odds ratio, weighted mean difference and 95% confidence interval. Review Manager Version 5 Software was used for the analysis of extracted data.
RESULTS AND CONCLUSION: Seven literatures were searched, including 5 addressing neuropsychological testing before and after surgery and 2 concerning cerebral metabolism. The pooled statistics showed lidocaine could not decrease in cognitive deficits, but there was a statistically significant decline of cognitive deficits in younger subgroup, low dose subgroup (P < 0.05). A decrease effect of lidocaine on Ca-jvO2, CERO2 and AVDL was observed during the whole CPB (P < 0.05). The incidence of death and withdraw showed no significant difference. There is no sufficient evidence to prove lidocaine is neuroprotective. But used in appropriate dosage regimens in specific clinical situations, lidocaine has neuroprotective effect.

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