Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2842-2846.doi: 10.3969/j.issn.1673-8225.2011.15.044

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Pathological changes of soft tissues and transforming growth factor beta 1 expression in radiation masseter injury models

Shen Zong-ze1, Zheng Jian-jin2, Jia Mu-yun3, Dong Gang2, Li Tao2   

  1. 1Medical College of Qingdao University, Qingdao  266067, Shandong Province, China
    2Department of Stomatology, Qingdao Municipal Hospital, Qingdao  266011, Shandong Province, China
    3Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Medical College of Qingdao University, Qingdao  266002, Shandong Province, China
  • Received:2010-12-20 Revised:2011-02-19 Online:2011-04-09 Published:2013-11-06
  • Contact: Zheng Jian-jin, Master, Chief physician, Professor, Master’s supervisor, Department of Stomatology, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
  • About author:Shen Zong-ze★, Studying for master’s degree, Medical College of Qingdao University, Qingdao 266067, Shandong Province, China johnnyshen886@ live.cn
  • Supported by:

    the Key Foundation of Science and Technology Bureau of Qingdao, No. 08-2-1-5-nsh*

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Abstract:

BACKGROUND: Long-term radioactive ray accumulation leads to surrounding tissues fibrosis accompanied by limitation of mouth-opening, which seriously affects life quality of tumor patients.
OBJECTIVE: To observe pathological change of soft tissues in rats with radiation masseter injury and the level of transforming growth factor β1 (TGF-β1) mRNA expression in vivo.
METHODS: A total of 30 Wistar rats were randomly divided into control group (n=10) and radiated group (n=20). Radiated group were radiated with linear accelerator at a dose of 40 Gy. The pathological changes of vessels were observed under light microscope and electron microscope and expression of TGF-β1 was detected by RT-PCR.
RESULTS AND CONCLUSION: The microvessel density of radiated group was obviously decreased than that of the control group (P < 0.01), but the mRNA expression of was higher than that in the control group (P < 0.01). It suggests that radiated injury can induce fibrosis to repair the radiated injury.

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